Receptor protein serine/threonine kinase

Receptor protein serine/threonine kinase

In enzymology, a receptor protein serine/threonine kinase (EC number| is an enzyme that catalyzes the chemical reaction

:ATP + [receptor-protein] ightleftharpoons ADP + [receptor-protein] phosphate

Thus, the two substrates of this enzyme are ATP and [receptor-protein] , whereas its two products are ADP and [receptor-protein] phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups protein-serine/threonine kinases. The systematic name of this enzyme class is ATP: [receptor-protein] phosphotransferase. Other names in common use include activin receptor kinase, receptor type I serine/threonine protein kinase, receptor type II serine/threonine protein kinase, STK13, TGF-beta kinase, and receptor serine/threonine protein kinase. This enzyme participates in 7 metabolic pathways: mapk signaling pathway, cytokine-cytokine receptor interaction, tgf-beta signaling pathway, adherens junction, colorectal cancer, pancreatic cancer, and chronic myeloid leukemia.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2GOO, PDB link|2H62, PDB link|2H64, PDB link|2HLQ, and PDB link|2HLR.



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