Class II PI 3-kinases

Class II PI 3-kinases

Class II PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation.

Class II PI 3-kinases were the most recently identified class of PI 3-kinases and little is currently known about these enzymes.

There are three class II PI 3-kinase isoforms expressed in mammalian cells;

  • PI3K-C2α
  • PI3K-C2β
  • PI3K-C2γ

See also

phosphoinositide 3-kinase

References

  • Stein RC( 2001) Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment Endocr Relat Cancer 8:237-248 [1]
  • Foster FM, Traer CJ, Abraham SM, and Fry MJ (2003) The phosphoinositide (PI) 3-kinase family J Cell Sci 116:3037-3040.[2]
  • Vanhaesebroeck B, Waterfield MD.(1999) Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res. 253(1):239-54.[3]


v · d · eTransferases: phosphorus-containing groups (EC 2.7)
2.7.1-2.7.4:
phosphotransferase/kinase
(PO4)
2.7.1: OH acceptor
2.7.2: COOH acceptor
2.7.3: N acceptor
2.7.4: PO4 acceptor
2.7.6: diphosphotransferase
(P2O7)
2.7.7: nucleotidyltransferase
(PO4-nucleoside)

DNA-directed DNA polymerase: DNA polymerase I · DNA polymerase II · DNA polymerase III holoenzyme
RNA-directed DNA polymerase: Reverse transcriptase (Telomerase)

DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase
RNA nucleotidyltransferase
Uridylyltransferase
Glucose-1-phosphate uridylyltransferase · Galactose-1-phosphate uridylyltransferase
Guanylyltransferase
mRNA capping enzyme
Other
2.7.8: miscellaneous
Phosphatidyltransferases
CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase · CDP-diacylglycerol—serine O-phosphatidyltransferase · CDP-diacylglycerol—inositol 3-phosphatidyltransferase · CDP-diacylglycerol—choline O-phosphatidyltransferase
Glycosyl-1-phosphotransferase
2.7.10-2.7.13: protein kinase
(PO4; protein acceptor)
see tyrosine kinases
see serine/threonine-specific protein kinases
2.7.12: protein-dual-specificity
see serine/threonine-specific protein kinases
2.7.13: protein-histidine
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

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