Shikimate kinase

Pfam_box
Symbol = SKI
Name =

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width =250
caption = Shikimate kinase of "Erwinia chrysanthemi"
Pfam= PF01202
InterPro= IPR000623
SMART=
PROSITE = PDOC00868
SCOP = 2shk
TCDB =
OPM family=
OPM protein= 1e6c
PDB=PDB3|1l4yA:11-167 PDB3|1we2A:11-167 PDB3|1l4uA:11-167PDB3|1u8aA:11-167 PDB3|2shkB:11-169 PDB3|1shkA:11-169PDB3|1e6cB:11-169 PDB3|1kagA:13-171

In enzymology, a shikimate kinase (EC number|2.7.1.71) is an enzyme that catalyzes the chemical reaction

:ATP + shikimate $ightleftharpoons$ ADP + shikimate 3-phosphate

Thus, the two substrates of this enzyme are ATP and shikimate, whereas its two products are ADP and shikimate 3-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:shikimate 3-phosphotransferase. Other names in common use include shikimate kinase (phosphorylating), and shikimate kinase II. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis.

tructural studies

As of late 2007, 26 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1E6C, PDB link|1KAG, PDB link|1L4U, PDB link|1L4Y, PDB link|1SHK, PDB link|1U8A, PDB link|1VIA, PDB link|1WE2, PDB link|1ZUH, PDB link|1ZUI, PDB link|1ZYU, PDB link|2DFN, PDB link|2DFT, PDB link|2G1J, PDB link|2G1K, PDB link|2IYQ, PDB link|2IYR, PDB link|2IYS, PDB link|2IYT, PDB link|2IYU, PDB link|2IYV, PDB link|2IYW, PDB link|2IYX, PDB link|2IYY, PDB link|2IYZ, and PDB link|2SHK.

Human proteins containing this domain

MAPK7; THNSL1;

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9031-51-0."

Gene Ontology (GO) codes