Mitogen-activated protein kinase kinase

Mitogen-activated protein kinase kinase

Mitogen-activated protein kinase kinase [sic] (also known as MAP2K) is a kinase enzyme which phosphorylates mitogen-activated protein kinase (MAPK).

MAP2K is classified as EC

There are seven genes:

The activators of p38 (MKK3 and MKK6), JNK (MKK4 and MKK7), and ERK (MEK1 and MEK2) define independent MAP kinase signal transduction pathways.[1]


  1. ^ Dérijard B, et al. (1995). "Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms". Science 267 (5198): 682–5. doi:10.1126/science.7839144. PMID 7839144. 

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