Mitogen-activated protein kinase kinase

Mitogen-activated protein kinase kinase: For other uses, see MKK (disambiguation).

Mitogen-activated protein kinase kinase [sic] (also known as MAP2K) is a kinase enzyme which phosphorylates mitogen-activated protein kinase (MAPK).

MAP2K is classified as EC 2.7.12.2.

There are seven genes:

MAP2K1 (aka MEK1)

MAP2K2 (aka MEK2)

MAP2K3 (aka MKK3)

MAP2K4 (aka MKK4}

MAP2K5 (aka MKK5)

MAP2K6 (aka MKK6)

MAP2K7 (aka MKK7)

The activators of p38 (MKK3 and MKK6), JNK (MKK4 and MKK7), and ERK (MEK1 and MEK2) define independent MAP kinase signal transduction pathways.^[1]

References

^ Dérijard B, et al. (1995). "Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms". Science 267 (5198): 682–5. doi:10.1126/science.7839144. PMID 7839144.

External links

MeSH Mitogen-Activated+Protein+Kinase+Kinases

v · d · eMAP kinase activation

Initiation
Mitogen

MAP kinase kinase kinase (MAP3K or MKKK)
MAP kinase kinase kinases (MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8) RAFs (ARAF, BRAF, KSR1, KSR2) MLKs (MAP3K12, MAP3K13, MAP3K9, MAP3K10, MAP3K11, MAP3K7, ZAK) CDC7

MAP kinase kinase (MAP2K or MKK)
MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7

MAP kinase
Extracellular signal-regulated (MAPK1, MAPK3, MAPK4, MAPK6, MAPK7, MAPK12, MAPK15), C-Jun N-terminal (MAPK8, MAPK9, MAPK10), P38 mitogen-activated protein (MAPK11, MAPK13, MAPK14)

Phosphatase
MAPK phosphatase

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

v · d · eTransferases: phosphorus-containing groups (EC 2.7)

2.7.1-2.7.4:
phosphotransferase/kinase
(PO₄)

2.7.1: OH acceptor

Hexo- · Gluco- · Fructo- (Hepatic) · Galacto- · Phosphofructo- (1, Liver, Muscle, Platelet, 2) · Riboflavin · Shikimate · Thymidine (ADP-thymidine) · NAD⁺ · Glycerol · Pantothenate · Mevalonate · Pyruvate · Deoxycytidine · PFP · Diacylglycerol · Phosphoinositide 3 (Class I PI 3, Class II PI 3) · Sphingosine · Glucose-1,6-bisphosphate synthase

2.7.2: COOH acceptor

Phosphoglycerate · Aspartate

2.7.3: N acceptor

Creatine

2.7.4: PO₄ acceptor

Phosphomevalonate · Adenylate · Nucleoside-diphosphate · Uridylate · Guanylate · Thiamine-diphosphate

2.7.6: diphosphotransferase
(P₂O₇)
Ribose-phosphate diphosphokinase · Thiamine diphosphokinase

2.7.7: nucleotidyltransferase
(PO₄-nucleoside)

Polymerase

DNA polymerase

DNA-directed DNA polymerase: DNA polymerase I · DNA polymerase II · DNA polymerase III holoenzyme
RNA-directed DNA polymerase: Reverse transcriptase (Telomerase)
DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase

RNA nucleotidyltransferase

RNA polymerase/DNA-directed RNA polymerase: RNA polymerase I · RNA polymerase II · RNA polymerase III · RNA polymerase IV · Primase · RNA-dependent RNA polymerase
PNPase

Phosphorolytic
3' to 5' exoribonuclease

RNase PH · PNPase

Uridylyltransferase

Glucose-1-phosphate uridylyltransferase · Galactose-1-phosphate uridylyltransferase

Guanylyltransferase

mRNA capping enzyme

Other

Recombinase (Integrase) · Transposase

2.7.8: miscellaneous

Phosphatidyltransferases

CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase · CDP-diacylglycerol—serine O-phosphatidyltransferase · CDP-diacylglycerol—inositol 3-phosphatidyltransferase · CDP-diacylglycerol—choline O-phosphatidyltransferase

Glycosyl-1-phosphotransferase

N-acetylglucosamine-1-phosphate transferase

2.7.10-2.7.13: protein kinase
(PO₄; protein acceptor)

2.7.10: protein-tyrosine

see tyrosine kinases

2.7.11: protein-serine/threonine

see serine/threonine-specific protein kinases

2.7.12: protein-dual-specificity

see serine/threonine-specific protein kinases

2.7.13: protein-histidine

Protein-histidine pros-kinase · Protein-histidine tele-kinase · Histidine kinase

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

v · d · eKinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

Non-specific serine/threonine protein kinases (EC 2.7.11.1)

LATS1, LATS2, MAST1, MAST2, STK38, STK38L, CIT, ROCK1, SGK, SGK2, SGK3, Protein kinase B (AKT1, AKT2, AKT3), Ataxia telangiectasia mutated, Mammalian target of rapamycin, EIF-2 kinases (PKR, HRI, EIF2AK3, EIF2AK4), Wee1 (WEE1)

Pyruvate dehydrogenase kinase (EC 2.7.11.2)

PDK1, PDK2, PDK3

Dephospho-(reductase kinase) kinase (EC 2.7.11.3)

AMP-activated protein kinase α (PRKAA1, PRKAA2) · β (PRKAB1, PRKAB2) · γ (PRKAG1, PRKAG2, PRKAG3)

(3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)) (EC 2.7.11.4)

BCKDK, BCKDHA, BCKDHB

(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)

IDH2, IDH3A, IDH3B, IDH3G

(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)

STK4

Myosin-heavy-chain kinase (EC 2.7.11.7)

Aurora kinase (Aurora A kinase, Aurora B kinase)

Fas-activated serine/threonine kinase (EC 2.7.11.8)

FASTK, STK10

Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)

-

IκB kinase (EC 2.7.11.10)

CHUK, IKK2, TBK1, IKBKE, IKBKG, IKBKAP

cAMP-dependent protein kinase (EC 2.7.11.11)

Protein kinase A, PRKACG, PRKACB, PRKACA, PRKY

cGMP-dependent protein kinase (EC 2.7.11.12)

Protein kinase G, PRKG1

Protein kinase C (EC 2.7.11.13)

Protein kinase C, Protein kinase Cζ, PKC alpha, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCG, PRKCI, PRKCQ, Protein kinase N1, PKN2, PKN3,

Rhodopsin kinase (EC 2.7.11.14)

Rhodopsin kinase

Beta adrenergic receptor kinase (EC 2.7.11.15)

Beta adrenergic receptor kinase, Beta adrenergic receptor kinase-2

G-protein coupled receptor kinases (EC 2.7.11.16)

GRK4, GRK5, GRK6

Ca2+/calmodulin-dependent (EC 2.7.11.17)

BRSK2, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, MLCK, CASK, CHEK1, CHEK2, DAPK1, DAPK2, DAPK3, STK11, MAPKAPK2, MAPKAPK3, MAPKAPK5, MARK1, MARK2, MARK3, MARK4, MELK, MKNK1, MKNK2, NUAK1, NUAK2, OBSCN, PASK, PHKG1, PHKG2, PIM1, PIM2, PKD1, PRKD2, PRKD3, PSKH1, SNF1LK2, KIAA0999, STK40, SNF1LK, SNRK, SPEG, TSSK2, Kalirin, TRIB1, TRIB2, TRIB3, TRIO, Titin, DCLK1

Myosin light-chain kinase (EC 2.7.11.18)

MYLK, MYLK2, MYLK3, MYLK4

Phosphorylase kinase (EC 2.7.11.19)

PHKA1, PHKA2, PHKB, PHKG1, PHKG2

Elongation factor 2 kinase (EC 2.7.11.20)

EEF2K, STK19

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

Polo kinase (EC 2.7.11.21)

PLK1, PLK2, PLK3, PLK4

Cyclin-dependent kinase (EC 2.7.11.22)

CDK1, CDK2, CDKL2, CDK3, CDK4, CDK5, CDKL5, CDK6, CDK7, CDK8, CDK9, CDK10, CDC2L5, CRKRS, PCTK1, PCTK2, PCTK3, PFTK1, CDC2L1

(RNA-polymerase)-subunit kinase (EC 2.7.11.23)

RPS6KA5, RPS6KA4, P70S6 kinase, P70-S6 Kinase 1, RPS6KB2, RPS6KA2, RPS6KA3, RPS6KA1, RPS6KC1

Mitogen-activated protein kinase (EC 2.7.11.24)

Extracellular signal-regulated (MAPK1, MAPK3, MAPK4, MAPK6, MAPK7, MAPK12, MAPK15), C-Jun N-terminal (MAPK8, MAPK9, MAPK10), P38 mitogen-activated protein (MAPK11, MAPK13, MAPK14)

MAP3K (EC 2.7.11.25)

MAP kinase kinase kinases (MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8) RAFs (ARAF, BRAF, KSR1, KSR2), MLKs (MAP3K12, MAP3K13, MAP3K9, MAP3K10, MAP3K11, MAP3K7, ZAK), CDC7, MAP3K14

Tau-protein kinase (EC 2.7.11.26)

TPK1, TTK, GSK-3

(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)

-

Tropomyosin kinase (EC 2.7.11.28)

-

Low-density-lipoprotein receptor kinase (EC 2.7.11.29)

-

Receptor protein serine/threonine kinase (EC 2.7.11.30)

Bone morphogenetic protein receptors (BMPR1, BMPR1A, BMPR1B, BMPR2), ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

MAP2K

MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

Categories:
Biochemistry stubs
Cell signaling
Signal transduction
Protein kinases

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Mitogen-activated protein kinase — Identifiers EC number 2.7.11.24 CAS number 142243 02 5 … Wikipedia
Mitogen-activated protein kinase 9 — Rendering based on PDB 3E7O … Wikipedia
mitogen-activated protein kinase — (MAPK) mi·to·gen ac·ti·vat·ed pro·tein ki·nase (MAPK) (miґto jən akґtĭ vāt əd proґtēn kiґnās) [EC 2.7.11.24] any of a group of protein serine/threonine kinases that when activated enter the cell nucleus and catalyze… … Medical dictionary
P38 mitogen-activated protein kinases — protein Name = mitogen activated protein kinase 11 caption = width = HGNCid = 6873 Symbol = MAPK11 AltSymbols = PRKM11 EntrezGene = 5600 OMIM = 602898 RefSeq = NM 002751 UniProt = Q15759 PDB = ECnumber = Chromosome = 22 Arm = Band =… … Wikipedia
p38 mitogen-activated protein kinases — Main article: Mitogen activated protein kinase P38 mitogen activated protein kinases are a class of mitogen activated protein kinases that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock … Wikipedia
Protein kinase A — In cell biology, Protein kinase A (PKA) refers to a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP dependent protein kinase (EC 2.7.11.11). Protein kinase A has several functions… … Wikipedia
Ca2+/calmodulin-dependent protein kinase — Calcium/calmodulin dependent protein kinase II association domain crystal structure of calcium/calmodulin dependent protein kinase Identifiers Symbol CaMKII AD … Wikipedia
Myotonin-protein kinase — Dystrophia myotonica protein kinase PDB rendering based on 1wt6 … Wikipedia
Serine/threonine-specific protein kinase — Serine/threonine protein kinases (EC number|2.7.11.1) phosphorylate the OH group of serine or threonine (which have similar sidechains). RegulationActivity of these protein kinases can be regulated by specific events (e.g. DNA damage), as well as … Wikipedia
Protein kinase — A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). This class of protein may further be separated into subsets as in the case of protein kinase C PKC alpha, PKC beta,… … Wikipedia

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Mitogen-activated protein kinase kinase

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