MAP2K5

MAP2K5

Mitogen-activated protein kinase kinase 5, also known as MAP2K5, is a human gene.cite web | title = Entrez Gene: MAP2K5 mitogen-activated protein kinase kinase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5607| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.cite web | title = Entrez Gene: MAP2K5 mitogen-activated protein kinase kinase 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5607| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=English JM, Vanderbilt CA, Xu S, "et al." |title=Isolation of MEK5 and differential expression of alternatively spliced forms. |journal=J. Biol. Chem. |volume=270 |issue= 48 |pages= 28897–902 |year= 1996 |pmid= 7499418 |doi=
*cite journal | author=Zhou G, Bao ZQ, Dixon JE |title=Components of a new human protein kinase signal transduction pathway. |journal=J. Biol. Chem. |volume=270 |issue= 21 |pages= 12665–9 |year= 1995 |pmid= 7759517 |doi=
*cite journal | author=Kato Y, Kravchenko VV, Tapping RI, "et al." |title=BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. |journal=EMBO J. |volume=16 |issue= 23 |pages= 7054–66 |year= 1998 |pmid= 9384584 |doi= 10.1093/emboj/16.23.7054
*cite journal | author=Kato Y, Tapping RI, Huang S, "et al." |title=Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor. |journal=Nature |volume=395 |issue= 6703 |pages= 713–6 |year= 1998 |pmid= 9790194 |doi= 10.1038/27234
*cite journal | author=English JM, Pearson G, Hockenberry T, "et al." |title=Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control. |journal=J. Biol. Chem. |volume=274 |issue= 44 |pages= 31588–92 |year= 1999 |pmid= 10531364 |doi=
*cite journal | author=Chao TH, Hayashi M, Tapping RI, "et al." |title=MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway. |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36035–8 |year= 2000 |pmid= 10593883 |doi=
*cite journal | author=Sun W, Kesavan K, Schaefer BC, "et al." |title=MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 5093–100 |year= 2001 |pmid= 11073940 |doi= 10.1074/jbc.M003719200
*cite journal | author=Diaz-Meco MT, Moscat J |title=MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling. |journal=Mol. Cell. Biol. |volume=21 |issue= 4 |pages= 1218–27 |year= 2001 |pmid= 11158308 |doi= 10.1128/MCB.21.4.1218-1227.2001
*cite journal | author=Nicol RL, Frey N, Pearson G, "et al." |title=Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy. |journal=EMBO J. |volume=20 |issue= 11 |pages= 2757–67 |year= 2001 |pmid= 11387209 |doi= 10.1093/emboj/20.11.2757
*cite journal | author=Dinev D, Jordan BW, Neufeld B, "et al." |title=Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells. |journal=EMBO Rep. |volume=2 |issue= 9 |pages= 829–34 |year= 2001 |pmid= 11520859 |doi= 10.1093/embo-reports/kve177
*cite journal | author=Weldon CB, Scandurro AB, Rolfe KW, "et al." |title=Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarray. |journal=Surgery |volume=132 |issue= 2 |pages= 293–301 |year= 2002 |pmid= 12219026 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Mehta PB, Jenkins BL, McCarthy L, "et al." |title=MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion. |journal=Oncogene |volume=22 |issue= 9 |pages= 1381–9 |year= 2003 |pmid= 12618764 |doi= 10.1038/sj.onc.1206154
*cite journal | author=Mody N, Campbell DG, Morrice N, "et al." |title=An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro. |journal=Biochem. J. |volume=372 |issue= Pt 2 |pages= 567–75 |year= 2003 |pmid= 12628002 |doi= 10.1042/BJ20030193
*cite journal | author=Huang J, Tu Z, Lee FS |title=Mutations in protein kinase subdomain X differentially affect MEKK2 and MEKK1 activity. |journal=Biochem. Biophys. Res. Commun. |volume=303 |issue= 2 |pages= 532–40 |year= 2003 |pmid= 12659851 |doi=
*cite journal | author=Lamark T, Perander M, Outzen H, "et al." |title=Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34568–81 |year= 2003 |pmid= 12813044 |doi= 10.1074/jbc.M303221200
*cite journal | author=Cameron SJ, Abe J, Malik S, "et al." |title=Differential role of MEK5alpha and MEK5beta in BMK1/ERK5 activation. |journal=J. Biol. Chem. |volume=279 |issue= 2 |pages= 1506–12 |year= 2004 |pmid= 14583600 |doi= 10.1074/jbc.M308755200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086
*cite journal | author=Raviv Z, Kalie E, Seger R |title=MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation. |journal=J. Cell. Sci. |volume=117 |issue= Pt 9 |pages= 1773–84 |year= 2004 |pmid= 15075238 |doi= 10.1242/jcs.01040

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