- GRK6
G protein-coupled receptor kinase 6, also known as GRK6, is a human
gene .cite web | title = Entrez Gene: GRK6 G protein-coupled receptor kinase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2870| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene.cite web | title = Entrez Gene: GRK6 G protein-coupled receptor kinase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2870| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Bullrich F, Druck T, Kunapuli P, "et al." |title=Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6. |journal=Cytogenet. Cell Genet. |volume=70 |issue= 3-4 |pages= 250–4 |year= 1995 |pmid= 7789183 |doi=
*cite journal | author=Stoffel RH, Randall RR, Premont RT, "et al." |title=Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. |journal=J. Biol. Chem. |volume=269 |issue= 45 |pages= 27791–4 |year= 1994 |pmid= 7961702 |doi=
*cite journal | author=Loudon RP, Benovic JL |title=Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6. |journal=J. Biol. Chem. |volume=269 |issue= 36 |pages= 22691–7 |year= 1994 |pmid= 8077221 |doi=
*cite journal | author=Benovic JL, Gomez J |title=Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family. |journal=J. Biol. Chem. |volume=268 |issue= 26 |pages= 19521–7 |year= 1993 |pmid= 8366096 |doi=
*cite journal | author=Haribabu B, Snyderman R |title=Identification of additional members of human G-protein-coupled receptor kinase multigene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 20 |pages= 9398–402 |year= 1993 |pmid= 8415712 |doi=
*cite journal | author=Freedman NJ, Ament AS, Oppermann M, "et al." |title=Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity. |journal=J. Biol. Chem. |volume=272 |issue= 28 |pages= 17734–43 |year= 1997 |pmid= 9211925 |doi=
*cite journal | author=Loudon RP, Benovic JL |title=Altered activity of palmitoylation-deficient and isoprenylated forms of the G protein-coupled receptor kinase GRK6. |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 27422–7 |year= 1997 |pmid= 9341194 |doi=
*cite journal | author=Stoffel RH, Inglese J, Macrae AD, "et al." |title=Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6. |journal=Biochemistry |volume=37 |issue= 46 |pages= 16053–9 |year= 1998 |pmid= 9819198 |doi= 10.1021/bi981432d
*cite journal | author=Premont RT, Claing A, Vitale N, "et al." |title=beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 24 |pages= 14082–7 |year= 1998 |pmid= 9826657 |doi=
*cite journal | author=Milcent MD, Christophe T, Rabiet MJ, "et al." |title=Overexpression of wild-type and catalytically inactive forms of GRK2 and GRK6 fails to alter the agonist-induced phosphorylation of the C5a receptor (CD88): evidence that GRK6 is autophosphorylated in COS-7 cells. |journal=Biochem. Biophys. Res. Commun. |volume=259 |issue= 1 |pages= 224–9 |year= 1999 |pmid= 10334944 |doi= 10.1006/bbrc.1999.0758
*cite journal | author=Lazari MF, Liu X, Nakamura K, "et al." |title=Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor. |journal=Mol. Endocrinol. |volume=13 |issue= 6 |pages= 866–78 |year= 1999 |pmid= 10379886 |doi=
*cite journal | author=Hall RA, Spurney RF, Premont RT, "et al." |title=G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction. |journal=J. Biol. Chem. |volume=274 |issue= 34 |pages= 24328–34 |year= 1999 |pmid= 10446210 |doi=
*cite journal | author=Brenninkmeijer CB, Price SA, López Bernal A, Phaneuf S |title=Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium. |journal=J. Endocrinol. |volume=162 |issue= 3 |pages= 401–8 |year= 1999 |pmid= 10467231 |doi=
*cite journal | author=Premont RT, Macrae AD, Aparicio SA, "et al." |title=The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. |journal=J. Biol. Chem. |volume=274 |issue= 41 |pages= 29381–9 |year= 1999 |pmid= 10506199 |doi=
*cite journal | author=Pronin AN, Morris AJ, Surguchov A, Benovic JL |title=Synucleins are a novel class of substrates for G protein-coupled receptor kinases. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26515–22 |year= 2000 |pmid= 10852916 |doi= 10.1074/jbc.M003542200
*cite journal | author=Tiruppathi C, Yan W, Sandoval R, "et al." |title=G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 13 |pages= 7440–5 |year= 2000 |pmid= 10861009 |doi=
*cite journal | author=Zhou H, Yan F, Tai HH |title=Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases. |journal=J. Pharmacol. Exp. Ther. |volume=298 |issue= 3 |pages= 1243–51 |year= 2001 |pmid= 11504827 |doi=
*cite journal | author=Blaukat A, Pizard A, Breit A, "et al." |title=Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 40431–40 |year= 2001 |pmid= 11517230 |doi= 10.1074/jbc.M107024200
*cite journal | author=Willets JM, Challiss RA, Nahorski SR |title=Endogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15523–9 |year= 2002 |pmid= 11856737 |doi= 10.1074/jbc.M111217200
*cite journal | author=Grange-Midroit M, García-Sevilla JA, Ferrer-Alcón M, "et al." |title=G protein-coupled receptor kinases, beta-arrestin-2 and associated regulatory proteins in the human brain: postmortem changes, effect of age and subcellular distribution. |journal=Brain Res. Mol. Brain Res. |volume=101 |issue= 1-2 |pages= 39–51 |year= 2002 |pmid= 12007830 |doi=PBB_Controls
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