GZMA

Granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3), also known as GZMA, is a human gene.cite web | title = Entrez Gene: GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3001| accessdate = ]

PBB_Summary
section_title =
summary_text = Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells.cite web | title = Entrez Gene: GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3001| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Pasternack MS, Bleier KJ, McInerney TN |title=Granzyme A binding to target cell proteins. Granzyme A binds to and cleaves nucleolin in vitro. |journal=J. Biol. Chem. |volume=266 |issue= 22 |pages= 14703–8 |year= 1991 |pmid= 1860869 |doi=
*cite journal | author=Poe M, Bennett CD, Biddison WE, "et al." |title=Human cytotoxic lymphocyte tryptase. Its purification from granules and the characterization of inhibitor and substrate specificity. |journal=J. Biol. Chem. |volume=263 |issue= 26 |pages= 13215–22 |year= 1988 |pmid= 3047119 |doi=
*cite journal | author=Murphy ME, Moult J, Bleackley RC, "et al." |title=Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes. |journal=Proteins |volume=4 |issue= 3 |pages= 190–204 |year= 1989 |pmid= 3237717 |doi= 10.1002/prot.340040306
*cite journal | author=Gershenfeld HK, Hershberger RJ, Shows TB, Weissman IL |title=Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 4 |pages= 1184–8 |year= 1988 |pmid= 3257574 |doi=
*cite journal | author=Hameed A, Lowrey DM, Lichtenheld M, Podack ER |title=Characterization of three serine esterases isolated from human IL-2 activated killer cells. |journal=J. Immunol. |volume=141 |issue= 9 |pages= 3142–7 |year= 1988 |pmid= 3262682 |doi=
*cite journal | author=Krähenbühl O, Rey C, Jenne D, "et al." |title=Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes. |journal=J. Immunol. |volume=141 |issue= 10 |pages= 3471–7 |year= 1988 |pmid= 3263427 |doi=
*cite journal | author=Masson D, Zamai M, Tschopp J |title=Identification of granzyme A isolated from cytotoxic T-lymphocyte-granules as one of the proteases encoded by CTL-specific genes. |journal=FEBS Lett. |volume=208 |issue= 1 |pages= 84–8 |year= 1986 |pmid= 3533635 |doi=
*cite journal | author=Baetz K, Isaaz S, Griffiths GM |title=Loss of cytotoxic T lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis. |journal=J. Immunol. |volume=154 |issue= 11 |pages= 6122–31 |year= 1995 |pmid= 7751653 |doi=
*cite journal | author=Inoue M, Hoshino T, Fukuma T, "et al." |title=Close co-localization of CD4 and a serine esterase tryptase TL2 on the cell-surface of human monocytoid and CD4+ lymphoid cells. |journal=Biochem. Biophys. Res. Commun. |volume=201 |issue= 3 |pages= 1390–5 |year= 1994 |pmid= 7912927 |doi= 10.1006/bbrc.1994.1857
*cite journal | author=Fink TM, Lichter P, Wekerle H, "et al." |title=The human granzyme A (HFSP, CTLA3) gene maps to 5q11-q12 and defines a new locus of the serine protease superfamily. |journal=Genomics |volume=18 |issue= 2 |pages= 401–3 |year= 1994 |pmid= 8288245 |doi= 10.1006/geno.1993.1483
*cite journal | author=Beresford PJ, Kam CM, Powers JC, Lieberman J |title=Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 17 |pages= 9285–90 |year= 1997 |pmid= 9256474 |doi=
*cite journal | author=Spaeny-Dekking EH, Hanna WL, Wolbink AM, "et al." |title=Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo. |journal=J. Immunol. |volume=160 |issue= 7 |pages= 3610–6 |year= 1998 |pmid= 9531325 |doi=
*cite journal | author=Zhang D, Beresford PJ, Greenberg AH, Lieberman J |title=Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 10 |pages= 5746–51 |year= 2001 |pmid= 11331782 |doi= 10.1073/pnas.101329598
*cite journal | author=Beresford PJ, Zhang D, Oh DY, "et al." |title=Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks. |journal=J. Biol. Chem. |volume=276 |issue= 46 |pages= 43285–93 |year= 2001 |pmid= 11555662 |doi= 10.1074/jbc.M108137200
*cite journal | author=Fan Z, Beresford PJ, Zhang D, Lieberman J |title=HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2810–20 |year= 2002 |pmid= 11909973 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Fan Z, Beresford PJ, Zhang D, "et al." |title=Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. |journal=Nat. Immunol. |volume=4 |issue= 2 |pages= 145–53 |year= 2003 |pmid= 12524539 |doi= 10.1038/ni885
*cite journal | author=Pinkoski MJ, Green DR |title=Granzyme A: the road less traveled. |journal=Nat. Immunol. |volume=4 |issue= 2 |pages= 106–8 |year= 2003 |pmid= 12555094 |doi= 10.1038/ni0203-106
*cite journal | author=Saito S, Iida A, Sekine A, "et al." |title=Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population. |journal=J. Hum. Genet. |volume=48 |issue= 5 |pages= 249–70 |year= 2003 |pmid= 12721789 |doi= 10.1007/s10038-003-0021-7
*cite journal | author=Bell JK, Goetz DH, Mahrus S, "et al." |title=The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity. |journal=Nat. Struct. Biol. |volume=10 |issue= 7 |pages= 527–34 |year= 2003 |pmid= 12819769 |doi= 10.1038/nsb944

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