Guanylate kinase

In enzymology, a guanylate kinase (EC number|2.7.4.8) is an enzyme that catalyzes the chemical reaction

:ATP + GMP $ightleftharpoons$ ADP + GDP

Thus, the two substrates of this enzyme are ATP and GMP, whereas its two products are ADP and GDP.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:(d)GMP phosphotransferase. Other names in common use include deoxyguanylate kinase, 5'-GMP kinase, GMP kinase, guanosine monophosphate kinase, and ATP:GMP phosphotransferase. This enzyme participates in purine metabolism.

tructural studies

As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1EX6, PDB link|1EX7, PDB link|1GKY, PDB link|1LVG, PDB link|1S4Q, PDB link|1S96, PDB link|1Z6G, PDB link|1Z8F, PDB link|1ZNW, PDB link|1ZNX, PDB link|1ZNY, PDB link|1ZNZ, PDB link|2AN9, PDB link|2ANB, PDB link|2ANC, PDB link|2F3R, PDB link|2F3T, PDB link|2J41, and PDB link|2QOR.

References

*
*
*
*
*

External links

::"The CAS registry number for this enzyme class is CAS registry|9026-59-9."

Gene Ontology (GO) codes