- Tau-protein kinase
In
enzymology , a tau-protein kinase (EC number|2.7.11.26) is anenzyme that catalyzes thechemical reaction :ATP + [tau-protein] ADP + O-phospho- [tau-protein]
Thus, the two substrates of this enzyme are ATP and
tau-protein , whereas its two products are ADP andO-phospho-tau-protein .This enzyme belongs to the family of
transferase s, specifically those transferring a phosphate group to the sidechainoxygen atom ofserine orthreonine residues inprotein s (protein-serine/threonine kinase s). The systematic name of this enzyme class is ATP: [tau-protein] O-phosphotransferase. Other names in common use include ATP:tau-protein O-hosphotransferase, brain protein kinase PK40erk, cdk5/p20, CDK5/p23, glycogen synthase kinase-3beta, GSK, protein tau kinase, STK31, tau kinase, [tau-protein] kinase, tau-protein kinase I, tau-protein kinase II, tau-tubulin kinase, TPK, TPK I, TPK II, and TTK. This enzyme participates in 14 metabolic pathways:erbb signaling pathway ,cell cycle ,wnt signaling pathway ,hedgehog signaling pathway ,axon guidance ,focal adhesion ,b cell receptor signaling pathway ,insulin signaling pathway ,melanogenesis ,alzheimer's disease ,colorectal cancer ,endometrial cancer ,prostate cancer , andbasal cell carcinoma .tructural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2JDO, PDB link|2JDR, and PDB link|2UW9.
References
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*External links
::"The
CAS registry number for this enzyme class is CAS registry|111694-09-8."Gene Ontology (GO) codes
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