PLK3

Polo-like kinase 3 (Drosophila), also known as PLK3, is a human gene.cite web | title = Entrez Gene: PLK3 polo-like kinase 3 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1263| accessdate = ]

PBB_Summary
section_title =
summary_text = Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.cite web | title = Entrez Gene: PLK3 polo-like kinase 3 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1263| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Li B, Ouyang B, Pan H, "et al." |title=Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas. |journal=J. Biol. Chem. |volume=271 |issue= 32 |pages= 19402–8 |year= 1996 |pmid= 8702627 |doi=
*cite journal | author=Peng CY, Graves PR, Thoma RS, "et al." |title=Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. |journal=Science |volume=277 |issue= 5331 |pages= 1501–5 |year= 1997 |pmid= 9278512 |doi=
*cite journal | author=Ouyang B, Pan H, Lu L, "et al." |title=Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions. |journal=J. Biol. Chem. |volume=272 |issue= 45 |pages= 28646–51 |year= 1997 |pmid= 9353331 |doi=
*cite journal | author=Kauselmann G, Weiler M, Wulff P, "et al." |title=The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity. |journal=EMBO J. |volume=18 |issue= 20 |pages= 5528–39 |year= 1999 |pmid= 10523297 |doi= 10.1093/emboj/18.20.5528
*cite journal | author=Ouyang B, Li W, Pan H, "et al." |title=The physical association and phosphorylation of Cdc25C protein phosphatase by Prk. |journal=Oncogene |volume=18 |issue= 44 |pages= 6029–36 |year= 1999 |pmid= 10557092 |doi= 10.1038/sj.onc.1202983
*cite journal | author=Shieh SY, Ahn J, Tamai K, "et al." |title=The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. |journal=Genes Dev. |volume=14 |issue= 3 |pages= 289–300 |year= 2000 |pmid= 10673501 |doi=
*cite journal | author=Dai W, Li Y, Ouyang B, "et al." |title=PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer. |journal=Genes Chromosomes Cancer |volume=27 |issue= 3 |pages= 332–6 |year= 2000 |pmid= 10679924 |doi=
*cite journal | author=Matsuoka S, Rotman G, Ogawa A, "et al." |title=Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 19 |pages= 10389–94 |year= 2000 |pmid= 10973490 |doi= 10.1073/pnas.190030497
*cite journal | author=Holtrich U, Wolf G, Yuan J, "et al." |title=Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages. |journal=Oncogene |volume=19 |issue= 42 |pages= 4832–9 |year= 2000 |pmid= 11039900 |doi= 10.1038/sj.onc.1203845
*cite journal | author=Bulavin DV, Higashimoto Y, Popoff IJ, "et al." |title=Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. |journal=Nature |volume=411 |issue= 6833 |pages= 102–7 |year= 2001 |pmid= 11333986 |doi= 10.1038/35075107
*cite journal | author=Xie S, Wu H, Wang Q, "et al." |title=Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway. |journal=J. Biol. Chem. |volume=276 |issue= 46 |pages= 43305–12 |year= 2001 |pmid= 11551930 |doi= 10.1074/jbc.M106050200
*cite journal | author=Latonen L, Taya Y, Laiho M |title=UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts. |journal=Oncogene |volume=20 |issue= 46 |pages= 6784–93 |year= 2001 |pmid= 11709713 |doi= 10.1038/sj.onc.1204883
*cite journal | author=Ahn JY, Li X, Davis HL, Canman CE |title=Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19389–95 |year= 2002 |pmid= 11901158 |doi= 10.1074/jbc.M200822200
*cite journal | author=Sumara I, Vorlaufer E, Stukenberg PT, "et al." |title=The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase. |journal=Mol. Cell |volume=9 |issue= 3 |pages= 515–25 |year= 2002 |pmid= 11931760 |doi=
*cite journal | author=Wang Q, Xie S, Chen J, "et al." |title=Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity. |journal=Mol. Cell. Biol. |volume=22 |issue= 10 |pages= 3450–9 |year= 2002 |pmid= 11971976 |doi=
*cite journal | author=Bahassi el M, Conn CW, Myer DL, "et al." |title=Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways. |journal=Oncogene |volume=21 |issue= 43 |pages= 6633–40 |year= 2002 |pmid= 12242661 |doi= 10.1038/sj.onc.1205850
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tsvetkov L, Xu X, Li J, Stern DF |title=Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8468–75 |year= 2003 |pmid= 12493754 |doi= 10.1074/jbc.M211202200
*cite journal | author=Xie S, Wu H, Wang Q, "et al." |title=Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2. |journal=Cell Cycle |volume=1 |issue= 6 |pages= 424–9 |year= 2003 |pmid= 12548019 |doi=
*cite journal | author=Bahassi el M, Hennigan RF, Myer DL, Stambrook PJ |title=Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation. |journal=Oncogene |volume=23 |issue= 15 |pages= 2658–63 |year= 2004 |pmid= 14968113 |doi= 10.1038/sj.onc.1207425

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