CLDN3

CLDN3

Claudin 3, also known as CLDN3, is a human gene.cite web | title = Entrez Gene: CLDN3 claudin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1365| accessdate = ] It belongs to the group of claudins.

PBB_Summary
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summary_text = Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat.cite web | title = Entrez Gene: CLDN3 claudin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1365| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kniesel U, Wolburg H |title=Tight junctions of the blood-brain barrier. |journal=Cell. Mol. Neurobiol. |volume=20 |issue= 1 |pages= 57–76 |year= 2000 |pmid= 10690502 |doi=
*cite journal | author=Heiskala M, Peterson PA, Yang Y |title=The roles of claudin superfamily proteins in paracellular transport. |journal=Traffic |volume=2 |issue= 2 |pages= 93–8 |year= 2001 |pmid= 11247307 |doi=
*cite journal | author=Tsukita S, Furuse M, Itoh M |title=Multifunctional strands in tight junctions. |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 4 |pages= 285–93 |year= 2001 |pmid= 11283726 |doi= 10.1038/35067088
*cite journal | author=Tsukita S, Furuse M |title=Claudin-based barrier in simple and stratified cellular sheets. |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 5 |pages= 531–6 |year= 2003 |pmid= 12231346 |doi=
*cite journal | author=González-Mariscal L, Betanzos A, Nava P, Jaramillo BE |title=Tight junction proteins. |journal=Prog. Biophys. Mol. Biol. |volume=81 |issue= 1 |pages= 1–44 |year= 2003 |pmid= 12475568 |doi=
*cite journal | author=Katahira J, Sugiyama H, Inoue N, "et al." |title=Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. |journal=J. Biol. Chem. |volume=272 |issue= 42 |pages= 26652–8 |year= 1997 |pmid= 9334247 |doi=
*cite journal | author=Peacock RE, Keen TJ, Inglehearn CF |title=Analysis of a human gene homologous to rat ventral prostate.1 protein. |journal=Genomics |volume=46 |issue= 3 |pages= 443–9 |year= 1998 |pmid= 9441748 |doi= 10.1006/geno.1997.5033
*cite journal | author=Morita K, Furuse M, Fujimoto K, Tsukita S |title=Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 2 |pages= 511–6 |year= 1999 |pmid= 9892664 |doi=
*cite journal | author=Furuse M, Sasaki H, Tsukita S |title=Manner of interaction of heterogeneous claudin species within and between tight junction strands. |journal=J. Cell Biol. |volume=147 |issue= 4 |pages= 891–903 |year= 1999 |pmid= 10562289 |doi=
*cite journal | author=Itoh M, Furuse M, Morita K, "et al." |title=Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. |journal=J. Cell Biol. |volume=147 |issue= 6 |pages= 1351–63 |year= 2000 |pmid= 10601346 |doi=
*cite journal | author=Miyamori H, Takino T, Kobayashi Y, "et al." |title=Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28204–11 |year= 2001 |pmid= 11382769 |doi= 10.1074/jbc.M103083200
*cite journal | author=Long H, Crean CD, Lee WH, "et al." |title=Expression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in prostate cancer epithelium. |journal=Cancer Res. |volume=61 |issue= 21 |pages= 7878–81 |year= 2001 |pmid= 11691807 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Katoh M, Katoh M |title=CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. |journal=Int. J. Mol. Med. |volume=11 |issue= 6 |pages= 683–9 |year= 2004 |pmid= 12736707 |doi=
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782

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