PRKCI

Protein kinase C, iota, also known as PRKCI, is a human gene.cite web | title = Entrez Gene: PRKCI protein kinase C, iota| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5584| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.cite web | title = Entrez Gene: PRKCI protein kinase C, iota| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5584| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Suzuki A, Akimoto K, Ohno S |title=Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms. |journal=J. Biochem. |volume=133 |issue= 1 |pages= 9–16 |year= 2003 |pmid= 12761193 |doi=
*cite journal | author=Fields AP, Regala RP |title=Protein kinase C iota: human oncogene, prognostic marker and therapeutic target. |journal=Pharmacol. Res. |volume=55 |issue= 6 |pages= 487–97 |year= 2007 |pmid= 17570678 |doi= 10.1016/j.phrs.2007.04.015
*cite journal | author=Ruegg CL, Strand M |title=A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx. |journal=Cell. Immunol. |volume=137 |issue= 1 |pages= 1–13 |year= 1991 |pmid= 1832084 |doi=
*cite journal | author=Chowdhury IH, Koyanagi Y, Kobayashi S, "et al." |title=The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway. |journal=Virology |volume=176 |issue= 1 |pages= 126–32 |year= 1990 |pmid= 1970444 |doi=
*cite journal | author=Ruegg CL, Strand M |title=Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41. |journal=J. Immunol. |volume=144 |issue= 10 |pages= 3928–35 |year= 1990 |pmid= 2139676 |doi=
*cite journal | author=Jakobovits A, Rosenthal A, Capon DJ |title=Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C. |journal=EMBO J. |volume=9 |issue= 4 |pages= 1165–70 |year= 1990 |pmid= 2182321 |doi=
*cite journal | author=Fields AP, Bednarik DP, Hess A, May WS |title=Human immunodeficiency virus induces phosphorylation of its cell surface receptor. |journal=Nature |volume=333 |issue= 6170 |pages= 278–80 |year= 1988 |pmid= 3259291 |doi= 10.1038/333278a0
*cite journal | author=Mazzarella R, Ciccodicola A, Esposito T, "et al." |title=Human protein kinase C Iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3. |journal=Genomics |volume=26 |issue= 3 |pages= 629–31 |year= 1995 |pmid= 7607695 |doi=
*cite journal | author=Chirmule N, Goonewardena H, Pahwa S, "et al." |title=HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells. |journal=J. Biol. Chem. |volume=270 |issue= 33 |pages= 19364–9 |year= 1995 |pmid= 7642615 |doi=
*cite journal | author=Ward NE, Gravitt KR, O'Brian CA |title=Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein. |journal=Cancer Lett. |volume=88 |issue= 1 |pages= 37–40 |year= 1995 |pmid= 7850771 |doi=
*cite journal | author=Gupta S, Aggarwal S, Kim C, Gollapudi S |title=Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report. |journal=Int. J. Immunopharmacol. |volume=16 |issue= 3 |pages= 197–204 |year= 1994 |pmid= 8206685 |doi=
*cite journal | author=Selbie LA, Schmitz-Peiffer C, Sheng Y, Biden TJ |title=Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells. |journal=J. Biol. Chem. |volume=268 |issue= 32 |pages= 24296–302 |year= 1993 |pmid= 8226978 |doi=
*cite journal | author=Diaz-Meco MT, Municio MM, Sanchez P, "et al." |title=Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo. |journal=Mol. Cell. Biol. |volume=16 |issue= 1 |pages= 105–14 |year= 1996 |pmid= 8524286 |doi=
*cite journal | author=Parada NA, Cruikshank WW, Danis HL, "et al." |title=IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C. |journal=Cell. Immunol. |volume=168 |issue= 1 |pages= 100–6 |year= 1996 |pmid= 8599832 |doi= 10.1006/cimm.1996.0054
*cite journal | author=Conant K, Ma M, Nath A, Major EO |title=Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes. |journal=J. Virol. |volume=70 |issue= 3 |pages= 1384–9 |year= 1996 |pmid= 8627654 |doi=
*cite journal | author=Díaz-Meco MT, Municio MM, Frutos S, "et al." |title=The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. |journal=Cell |volume=86 |issue= 5 |pages= 777–86 |year= 1996 |pmid= 8797824 |doi=
*cite journal | author=Holmes AM |title=In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46. |journal=Arch. Biochem. Biophys. |volume=335 |issue= 1 |pages= 8–12 |year= 1996 |pmid= 8914829 |doi= 10.1006/abbi.1996.0476
*cite journal | author=Murray NR, Fields AP |title=Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis. |journal=J. Biol. Chem. |volume=272 |issue= 44 |pages= 27521–4 |year= 1997 |pmid= 9346882 |doi=
*cite journal | author=Borgatti P, Zauli G, Cantley LC, Capitani S |title=Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 2 |pages= 332–7 |year= 1998 |pmid= 9446795 |doi=
*cite journal | author=Sanchez P, De Carcer G, Sandoval IV, "et al." |title=Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 3069–80 |year= 1998 |pmid= 9566925 |doi=

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