ROCK1

ROCK1

Rho-associated, coiled-coil containing protein kinase 1, also known as ROCK1, is a protein serine/threonine kinase, but also denotes the human gene encoding it.

It is activated when bound to the GTP-bound form of Rho GTPase. This protein is thus a downstream effector of Rho. It phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [cite web | title = Entrez Gene: ROCK1 Rho-associated, coiled-coil containing protein kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6093| accessdate = ] Thus, ROCK1 contributes to actin-stability.

ee also

* Rho kinase

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Riento K, Ridley AJ |title=Rocks: multifunctional kinases in cell behaviour. |journal=Nat. Rev. Mol. Cell Biol. |volume=4 |issue= 6 |pages= 446–56 |year= 2003 |pmid= 12778124 |doi= 10.1038/nrm1128

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