NUAK1

NUAK family, SNF1-like kinase, 1
Identifiers
Symbols	NUAK1; ARK5; KIAA0537
External IDs	OMIM: 608130 MGI: 1925226 HomoloGene: 8896 GeneCards: NUAK1 Gene
EC number	2.7.11.1
Gene Ontology Molecular function • nucleotide binding • protein serine/threonine kinase activity • protein binding • ATP binding • metal ion binding Biological process • protein amino acid phosphorylation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9891	77976
Ensembl	ENSG00000074590	ENSMUSG00000020032
UniProt	O60285	Q641K5
RefSeq (mRNA)	NM_014840	NM_001004363.1
RefSeq (protein)	NP_055655	NP_001004363.1
Location (UCSC)	Chr 12: 106.46 – 106.53 Mb	Chr 10: 83.83 – 83.9 Mb
PubMed search	[1]	[2]

NUAK family SNF1-like kinase 1 also known as AMPK-related protein kinase 5 (ARK5) is an enzyme that in humans is encoded by the NUAK1 gene.^[1][2][3]

Interactions

NUAK1 has been shown to interact with USP9X^[4] and Ubiquitin C.^[4]

References

1. ^ Suzuki A, Kusakai G, Kishimoto A, Lu J, Ogura T, Lavin MF, Esumi H (Dec 2002). "Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein". J Biol Chem 278 (1): 48–53. doi:10.1074/jbc.M206025200. PMID 12409306. 
2. ^ Suzuki A, Kusakai G, Kishimoto A, Lu J, Ogura T, Esumi H (Sep 2003). "ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation". Oncogene 22 (40): 6177–82. doi:10.1038/sj.onc.1206899. PMID 13679856. 
3. ^ "Entrez Gene: NUAK1 NUAK family, SNF1-like kinase, 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9891. 
4. ^ ^{a b} Al-Hakim, Abdallah K; Zagorska Anna, Chapman Louise, Deak Maria, Peggie Mark, Alessi Dario R (Apr. 2008). "Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains". Biochem. J. (England) 411 (2): 249–60. doi:10.1042/BJ20080067. PMID 18254724. 

Further reading

• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Lizcano JM, Göransson O, Toth R, et al. (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.". EMBO J. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=381014. 
• Suzuki A, Lu J, Kusakai G, et al. (2004). "ARK5 is a tumor invasion-associated factor downstream of Akt signaling.". Mol. Cell. Biol. 24 (8): 3526–35. doi:10.1128/MCB.24.8.3526-3535.2004. PMC 381626. PMID 15060171. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=381626. 
• Suzuki A, Kusakai G, Kishimoto A, et al. (2004). "Regulation of caspase-6 and FLIP by the AMPK family member ARK5.". Oncogene 23 (42): 7067–75. doi:10.1038/sj.onc.1207963. PMID 15273717. 
• Kusakai G, Suzuki A, Ogura T, et al. (2005). "Strong association of ARK5 with tumor invasion and metastasis.". J. Exp. Clin. Cancer Res. 23 (2): 263–8. PMID 15354411. 
• Suzuki A, Iida S, Kato-Uranishi M, et al. (2006). "ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma.". Oncogene 24 (46): 6936–44. doi:10.1038/sj.onc.1208844. PMID 16044163. 
• Al-Hakim AK, Göransson O, Deak M, et al. (2006). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.". J. Cell. Sci. 118 (Pt 23): 5661–73. doi:10.1242/jcs.02670. PMID 16306228. 
• Suzuki A, Ogura T, Esumi H (2006). "NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling.". J. Biol. Chem. 281 (20): 13915–21. doi:10.1074/jbc.M511354200. PMID 16488889. 
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948. 

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21) PLK1, PLK2, PLK3, PLK4 Cyclin-dependent kinase (EC 2.7.11.22) CDK1, CDK2, CDKL2, CDK3, CDK4, CDK5, CDKL5, CDK6, CDK7, CDK8, CDK9, CDK10, CDC2L5, CRKRS, PCTK1, PCTK2, PCTK3, PFTK1, CDC2L1 (RNA-polymerase)-subunit kinase (EC 2.7.11.23) RPS6KA5, RPS6KA4, P70S6 kinase, P70-S6 Kinase 1, RPS6KB2, RPS6KA2, RPS6KA3, RPS6KA1, RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24) Extracellular signal-regulated (MAPK1, MAPK3, MAPK4, MAPK6, MAPK7, MAPK12, MAPK15), C-Jun N-terminal (MAPK8, MAPK9, MAPK10), P38 mitogen-activated protein (MAPK11, MAPK13, MAPK14) MAP3K (EC 2.7.11.25) MAP kinase kinase kinases (MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8) RAFs (ARAF, BRAF, KSR1, KSR2), MLKs (MAP3K12, MAP3K13, MAP3K9, MAP3K10, MAP3K11, MAP3K7, ZAK), CDC7, MAP3K14 Tau-protein kinase (EC 2.7.11.26) TPK1, TTK, GSK-3 (acetyl-CoA carboxylase) kinase (EC 2.7.11.27) - Tropomyosin kinase (EC 2.7.11.28) - Low-density-lipoprotein receptor kinase (EC 2.7.11.29) - Receptor protein serine/threonine kinase (EC 2.7.11.30) Bone morphogenetic protein receptors (BMPR1, BMPR1A, BMPR1B, BMPR2), ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)
MAP2K MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6