- ACVR2A
Protbox
Name = Activin receptor type-2A
Domains=TS domain ,S/T domain
Taxa = "Homo sapiens "; homologs: manymetazoan phyla
Cofactors=Magnesium ormanganese Activin A receptor, type IIA, also known as ACVR2A, is a human
gene .cite web | title = Entrez Gene: ACVR2A activin A receptor, type IIA| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=92| accessdate = ] ACVR2A is anactivin type 2 receptor . PBB_Summary
section_title =
summary_text = This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.cite web | title = Entrez Gene: ACVR2A activin A receptor, type IIA| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=92| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Welt CK |title=The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction. |journal=Curr. Opin. Obstet. Gynecol. |volume=14 |issue= 3 |pages= 317–23 |year= 2002 |pmid= 12032389 |doi=
*cite journal | author=Matzuk MM, Bradley A |title=Cloning of the human activin receptor cDNA reveals high evolutionary conservation. |journal=Biochim. Biophys. Acta |volume=1130 |issue= 1 |pages= 105–8 |year= 1992 |pmid= 1311955 |doi=
*cite journal | author=Donaldson CJ, Mathews LS, Vale WW |title=Molecular cloning and binding properties of the human type II activin receptor. |journal=Biochem. Biophys. Res. Commun. |volume=184 |issue= 1 |pages= 310–6 |year= 1992 |pmid= 1314589 |doi=
*cite journal | author=Mathews LS, Vale WW |title=Expression cloning of an activin receptor, a predicted transmembrane serine kinase. |journal=Cell |volume=65 |issue= 6 |pages= 973–82 |year= 1991 |pmid= 1646080 |doi=
*cite journal | author=Xu J, McKeehan K, Matsuzaki K, McKeehan WL |title=Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism. |journal=J. Biol. Chem. |volume=270 |issue= 11 |pages= 6308–13 |year= 1995 |pmid= 7890768 |doi=
*cite journal | author=Attisano L, Cárcamo J, Ventura F, "et al." |title=Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors. |journal=Cell |volume=75 |issue= 4 |pages= 671–80 |year= 1993 |pmid= 8242742 |doi=
*cite journal | author=Peng C, Huang TH, Jeung EB, "et al." |title=Expression of the type II activin receptor gene in the human placenta. |journal=Endocrinology |volume=133 |issue= 6 |pages= 3046–9 |year= 1994 |pmid= 8243335 |doi=
*cite journal | author=De Winter JP, De Vries CJ, Van Achterberg TA, "et al." |title=Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors. |journal=Exp. Cell Res. |volume=224 |issue= 2 |pages= 323–34 |year= 1996 |pmid= 8612709 |doi=
*cite journal | author=Attisano L, Wrana JL, Montalvo E, Massagué J |title=Activation of signalling by the activin receptor complex. |journal=Mol. Cell. Biol. |volume=16 |issue= 3 |pages= 1066–73 |year= 1996 |pmid= 8622651 |doi=
*cite journal | author=Liu QY, Niranjan B, Gomes P, "et al." |title=Inhibitory effects of activin on the growth and morpholgenesis of primary and transformed mammary epithelial cells. |journal=Cancer Res. |volume=56 |issue= 5 |pages= 1155–63 |year= 1996 |pmid= 8640777 |doi=
*cite journal | author=Nishitoh H, Ichijo H, Kimura M, "et al." |title=Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5. |journal=J. Biol. Chem. |volume=271 |issue= 35 |pages= 21345–52 |year= 1996 |pmid= 8702914 |doi=
*cite journal | author=Lebrun JJ, Vale WW |title=Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation. |journal=Mol. Cell. Biol. |volume=17 |issue= 3 |pages= 1682–91 |year= 1997 |pmid= 9032295 |doi=
*cite journal | author=Macías-Silva M, Hoodless PA, Tang SJ, "et al." |title=Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25628–36 |year= 1998 |pmid= 9748228 |doi=
*cite journal | author=Barbara NP, Wrana JL, Letarte M |title=Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. |journal=J. Biol. Chem. |volume=274 |issue= 2 |pages= 584–94 |year= 1999 |pmid= 9872992 |doi=
*cite journal | author=Lux A, Attisano L, Marchuk DA |title=Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 9984–92 |year= 1999 |pmid= 10187774 |doi=
*cite journal | author=D'Abronzo FH, Swearingen B, Klibanski A, Alexander JM |title=Mutational analysis of activin/transforming growth factor-beta type I and type II receptor kinases in human pituitary tumors. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 5 |pages= 1716–21 |year= 1999 |pmid= 10323406 |doi=
*cite journal | author=Ebisawa T, Tada K, Kitajima I, "et al." |title=Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation. |journal=J. Cell. Sci. |volume=112 ( Pt 20) |issue= |pages= 3519–27 |year= 2000 |pmid= 10504300 |doi=
*cite journal | author=van Schaik RH, Wierikx CD, Timmerman MA, "et al." |title=Variations in activin receptor, inhibin/activin subunit and follistatin mRNAs in human prostate tumour tissues. |journal=Br. J. Cancer |volume=82 |issue= 1 |pages= 112–7 |year= 2000 |pmid= 10638976 |doi= 10.1054/bjoc.1999.0886
*cite journal | author=Shoji H, Tsuchida K, Kishi H, "et al." |title=Identification and characterization of a PDZ protein that interacts with activin type II receptors. |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5485–92 |year= 2000 |pmid= 10681527 |doi=
*cite journal | author=Bondestam J, Horelli-Kuitunen N, Hildén K, "et al." |title=Assignment of ACVR2 and ACVR2B the human activin receptor type II and IIB genes to chromosome bands 2q22.2-->q23.3 and 3p22 and the human follistatin gene (FST) to chromosome 5q11.2 by FISH. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3-4 |pages= 219–20 |year= 2000 |pmid= 10702675 |doi=Category:S/T domain PBB_Controls
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