- ACVR2B
Protbox
Name=Activin receptor type 2B
Domains=TS domain ,S/T domain
Taxa = "Homo sapiens "; homologs: manymetazoan phyla
Catalytic_activity=ATP + (receptor-protein) = ADP + (receptor-protein) phosphate
Cofactors=Magnesium ormanganese Activin A receptor, type IIB, also known as ACVR2B, is a human
gene .cite web | title = Entrez Gene: ACVR2B activin A receptor, type IIB| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=93| accessdate = ] ACVR2B is anactivin type 2 receptor . PBB_Summary
section_title =
summary_text = Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.cite web | title = Entrez Gene: ACVR2B activin A receptor, type IIB| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=93| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Burdine RD, Schier AF |title=Conserved and divergent mechanisms in left-right axis formation. |journal=Genes Dev. |volume=14 |issue= 7 |pages= 763–76 |year= 2000 |pmid= 10766733 |doi=
*cite journal | author=Hildén K, Tuuri T, Erämaa M, Ritvos O |title=Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor. |journal=Blood |volume=83 |issue= 8 |pages= 2163–70 |year= 1994 |pmid= 8161782 |doi=
*cite journal | author=De Winter JP, De Vries CJ, Van Achterberg TA, "et al." |title=Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors. |journal=Exp. Cell Res. |volume=224 |issue= 2 |pages= 323–34 |year= 1996 |pmid= 8612709 |doi=
*cite journal | author=Attisano L, Wrana JL, Montalvo E, Massagué J |title=Activation of signalling by the activin receptor complex. |journal=Mol. Cell. Biol. |volume=16 |issue= 3 |pages= 1066–73 |year= 1996 |pmid= 8622651 |doi=
*cite journal | author=Nishitoh H, Ichijo H, Kimura M, "et al." |title=Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5. |journal=J. Biol. Chem. |volume=271 |issue= 35 |pages= 21345–52 |year= 1996 |pmid= 8702914 |doi=
*cite journal | author=Martens JW, de Winter JP, Timmerman MA, "et al." |title=Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells. |journal=Endocrinology |volume=138 |issue= 7 |pages= 2928–36 |year= 1997 |pmid= 9202237 |doi=
*cite journal | author=Ishikawa S, Kai M, Murata Y, "et al." |title=Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene. |journal=J. Hum. Genet. |volume=43 |issue= 2 |pages= 132–4 |year= 1998 |pmid= 9621519 |doi=
*cite journal | author=Macías-Silva M, Hoodless PA, Tang SJ, "et al." |title=Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25628–36 |year= 1998 |pmid= 9748228 |doi=
*cite journal | author=Kosaki R, Gebbia M, Kosaki K, "et al." |title=Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. |journal=Am. J. Med. Genet. |volume=82 |issue= 1 |pages= 70–6 |year= 1999 |pmid= 9916847 |doi=
*cite journal | author=Lee S, Alexander J, Blowes R, "et al." |title=Determination of resonance frequency of the respiratory system in respiratory distress syndrome. |journal=Arch. Dis. Child. Fetal Neonatal Ed. |volume=80 |issue= 3 |pages= F198–202 |year= 2000 |pmid= 10212081 |doi=
*cite journal | author=McPherron AC, Lawler AM, Lee SJ |title=Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11. |journal=Nat. Genet. |volume=22 |issue= 3 |pages= 260–4 |year= 1999 |pmid= 10391213 |doi= 10.1038/10320
*cite journal | author=Bondestam J, Horelli-Kuitunen N, Hildén K, "et al." |title=Assignment of ACVR2 and ACVR2B the human activin receptor type II and IIB genes to chromosome bands 2q22.2-->q23.3 and 3p22 and the human follistatin gene (FST) to chromosome 5q11.2 by FISH. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3-4 |pages= 219–20 |year= 2000 |pmid= 10702675 |doi=
*cite journal | author=Chapman SC, Woodruff TK |title=Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP). |journal=Mol. Endocrinol. |volume=15 |issue= 4 |pages= 668–79 |year= 2001 |pmid= 11266516 |doi=
*cite journal | author=Wurthner JU, Frank DB, Felici A, "et al." |title=Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19495–502 |year= 2001 |pmid= 11278302 |doi= 10.1074/jbc.M006473200
*cite journal | author=Parks WT, Frank DB, Huff C, "et al." |title=Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19332–9 |year= 2001 |pmid= 11279102 |doi= 10.1074/jbc.M100606200
*cite journal | author=Choi KC, Kang SK, Nathwani PS, "et al." |title=Differential expression of activin/inhibin subunit and activin receptor mRNAs in normal and neoplastic ovarian surface epithelium (OSE). |journal=Mol. Cell. Endocrinol. |volume=174 |issue= 1-2 |pages= 99–110 |year= 2001 |pmid= 11306176 |doi=
*cite journal | author=Lee SJ, McPherron AC |title=Regulation of myostatin activity and muscle growth. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 16 |pages= 9306–11 |year= 2001 |pmid= 11459935 |doi= 10.1073/pnas.151270098
*cite journal | author=Matsuzaki T, Hanai S, Kishi H, "et al." |title=Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway. |journal=J. Biol. Chem. |volume=277 |issue= 21 |pages= 19008–18 |year= 2002 |pmid= 11882656 |doi= 10.1074/jbc.M112472200
*cite journal | author=Schneider-Kolsky ME, Manuelpillai U, Waldron K, "et al." |title=The distribution of activin and activin receptors in gestational tissues across human pregnancy and during labour. |journal=Placenta |volume=23 |issue= 4 |pages= 294–302 |year= 2002 |pmid= 11969340 |doi= 10.1053/plac.2002.0787Category:S/T domain PBB_Controls
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