ACVR1C

ACVR1C

Protbox
Name=Activin receptor type 1C
Photo=
Caption=
Gene = HUGO code: [http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC:18123 ACVR1C]
Structure =
Review =
Type=Serine/Threonine receptor kinase
Functions=
Domains= GS domain, TS domain, S/T domain
Diseases=
Taxa = "Homo sapiens"; homologs: many metazoan phyla
Cells = ubiquitous
Location =Plasma membrane
Catalytic_activity=ATP + (receptor-protein) = ADP + (receptor-protein) phosphate
Cofactors=Magnesium or manganese
Enzyme_regulation
Actions=
Agonists=
Antagonists
Mods=
Names= ACTR-IC, Activin receptor-like kinase 7, ALK-7
Interactions=
Pages=

ACVR1C or ALK-7 transduces signals of Nodal. Nodal binds to ACVR2B and then forms a comlex with ACR1C. These go on to recruit the R-SMADs SMAD2 or SMAD3.cite journal
last = Inman
first = GJ
authorlink =
coauthors = Nicolas FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS.
year = 2002
month = Jul
title = SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
journal = Mol Pharmacol.
volume = 62
issue = 1
page =
pages =
article =
doi =
id = Entrez Pubmed|12065756
url =http://molpharm.aspetjournals.org/cgi/content/full/62/1/65
format =
accessdate =2006-07-05 ]

References

Category:S/T domain


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