RPS6KA2

RPS6KA2

Ribosomal protein S6 kinase, 90kDa, polypeptide 2, also known as RPS6KA2, is a human gene.cite web | title = Entrez Gene: RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6196| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.cite web | title = Entrez Gene: RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6196| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=
*cite journal | author=Zhao Y, Bjørbaek C, Weremowicz S, "et al." |title=RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation. |journal=Mol. Cell. Biol. |volume=15 |issue= 8 |pages= 4353–63 |year= 1995 |pmid= 7623830 |doi=
*cite journal | author=Moller DE, Xia CH, Tang W, "et al." |title=Human rsk isoforms: cloning and characterization of tissue-specific expression. |journal=Am. J. Physiol. |volume=266 |issue= 2 Pt 1 |pages= C351–9 |year= 1994 |pmid= 8141249 |doi=
*cite journal | author=Wong EV, Schaefer AW, Landreth G, Lemmon V |title=Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1. |journal=J. Biol. Chem. |volume=271 |issue= 30 |pages= 18217–23 |year= 1996 |pmid= 8663493 |doi=
*cite journal | author=Xing J, Ginty DD, Greenberg ME |title=Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. |journal=Science |volume=273 |issue= 5277 |pages= 959–63 |year= 1996 |pmid= 8688081 |doi=
*cite journal | author=Zhao Y, Bjorbaek C, Moller DE |title=Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases. |journal=J. Biol. Chem. |volume=271 |issue= 47 |pages= 29773–9 |year= 1997 |pmid= 8939914 |doi=
*cite journal | author=Fukunaga R, Hunter T |title=MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. |journal=EMBO J. |volume=16 |issue= 8 |pages= 1921–33 |year= 1997 |pmid= 9155018 |doi= 10.1093/emboj/16.8.1921
*cite journal | author=del Peso L, González-García M, Page C, "et al." |title=Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. |journal=Science |volume=278 |issue= 5338 |pages= 687–9 |year= 1997 |pmid= 9381178 |doi=
*cite journal | author=Deak M, Clifton AD, Lucocq LM, Alessi DR |title=Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. |journal=EMBO J. |volume=17 |issue= 15 |pages= 4426–41 |year= 1998 |pmid= 9687510 |doi= 10.1093/emboj/17.15.4426
*cite journal | author=Du K, Montminy M |title=CREB is a regulatory target for the protein kinase Akt/PKB. |journal=J. Biol. Chem. |volume=273 |issue= 49 |pages= 32377–9 |year= 1999 |pmid= 9829964 |doi=
*cite journal | author=Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW |title=Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo. |journal=J. Biol. Chem. |volume=274 |issue= 5 |pages= 2893–8 |year= 1999 |pmid= 9915826 |doi=
*cite journal | author=Jensen CJ, Buch MB, Krag TO, "et al." |title=90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1. |journal=J. Biol. Chem. |volume=274 |issue= 38 |pages= 27168–76 |year= 1999 |pmid= 10480933 |doi=
*cite journal | author=Schimenti JC |title=ORFless, intronless, and mutant transcription units in the mouse t complex responder (Tcr) locus. |journal=Mamm. Genome |volume=10 |issue= 10 |pages= 969–76 |year= 2000 |pmid= 10501965 |doi=
*cite journal | author=Scheid MP, Schubert KM, Duronio V |title=Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase. |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 31108–13 |year= 1999 |pmid= 10521512 |doi=
*cite journal | author=Tan Y, Demeter MR, Ruan H, Comb MJ |title=BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25865–9 |year= 2000 |pmid= 10837486 |doi= 10.1074/jbc.M004199200
*cite journal | author=Lizcano JM, Morrice N, Cohen P |title=Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155. |journal=Biochem. J. |volume=349 |issue= Pt 2 |pages= 547–57 |year= 2001 |pmid= 10880354 |doi=
*cite journal | author=Datta SR, Katsov A, Hu L, "et al." |title=14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. |journal=Mol. Cell |volume=6 |issue= 1 |pages= 41–51 |year= 2000 |pmid= 10949026 |doi=
*cite journal | author=Gudi T, Casteel DE, Vinson C, "et al." |title=NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation. |journal=Oncogene |volume=19 |issue= 54 |pages= 6324–33 |year= 2001 |pmid= 11175347 |doi= 10.1038/sj.onc.1204007
*cite journal | author=Willard FS, Crouch MF |title=MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit. |journal=Cell. Signal. |volume=13 |issue= 9 |pages= 653–64 |year= 2001 |pmid= 11495723 |doi=
*cite journal | author=Schinelli S, Zanassi P, Paolillo M, "et al." |title=Stimulation of endothelin B receptors in astrocytes induces cAMP response element-binding protein phosphorylation and c-fos expression via multiple mitogen-activated protein kinase signaling pathways. |journal=J. Neurosci. |volume=21 |issue= 22 |pages= 8842–53 |year= 2001 |pmid= 11698596 |doi=

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