MAP2K4

Mitogen-activated protein kinase kinase 4, also known as MAP2K4, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK1. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [cite web | title = Entrez Gene: MAP2K4 mitogen-activated protein kinase kinase 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6416| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lin A, Minden A, Martinetto H, "et al." |title=Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. |journal=Science |volume=268 |issue= 5208 |pages= 286–90 |year= 1995 |pmid= 7716521 |doi=
*cite journal | author=Dérijard B, Raingeaud J, Barrett T, "et al." |title=Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. |journal=Science |volume=267 |issue= 5198 |pages= 682–5 |year= 1995 |pmid= 7839144 |doi=
*cite journal | author=Yan M, Dai T, Deak JC, "et al." |title=Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. |journal=Nature |volume=372 |issue= 6508 |pages= 798–800 |year= 1995 |pmid= 7997270 |doi=
*cite journal | author=Salmeron A, Ahmad TB, Carlile GW, "et al." |title=Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase. |journal=EMBO J. |volume=15 |issue= 4 |pages= 817–26 |year= 1996 |pmid= 8631303 |doi=
*cite journal | author=Gale NW, Holland SJ, Valenzuela DM, "et al." |title=Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. |journal=Neuron |volume=17 |issue= 1 |pages= 9–19 |year= 1996 |pmid= 8755474 |doi=
*cite journal | author=White RA, Hughes RT, Adkison LR, "et al." |title=The gene encoding protein kinase SEK1 maps to mouse chromosome 11 and human chromosome 17. |journal=Genomics |volume=34 |issue= 3 |pages= 430–2 |year= 1996 |pmid= 8786147 |doi= 10.1006/geno.1996.0309
*cite journal | author=Nishina H, Fischer KD, Radvanyi L, "et al." |title=Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. |journal=Nature |volume=385 |issue= 6614 |pages= 350–3 |year= 1997 |pmid= 9002521 |doi= 10.1038/385350a0
*cite journal | author=Marti A, Luo Z, Cunningham C, "et al." |title=Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells. |journal=J. Biol. Chem. |volume=272 |issue= 5 |pages= 2620–8 |year= 1997 |pmid= 9006895 |doi=
*cite journal | author=Deacon K, Blank JL |title=Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. |journal=J. Biol. Chem. |volume=272 |issue= 22 |pages= 14489–96 |year= 1997 |pmid= 9162092 |doi=
*cite journal | author=Hirai S, Katoh M, Terada M, "et al." |title=MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase. |journal=J. Biol. Chem. |volume=272 |issue= 24 |pages= 15167–73 |year= 1997 |pmid= 9182538 |doi=
*cite journal | author=Teng DH, Perry WL, Hogan JK, "et al." |title=Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor. |journal=Cancer Res. |volume=57 |issue= 19 |pages= 4177–82 |year= 1997 |pmid= 9331070 |doi=
*cite journal | author=Xu S, Cobb MH |title=MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32056–60 |year= 1998 |pmid= 9405400 |doi=
*cite journal | author=Guan Z, Buckman SY, Pentland AP, "et al." |title=Induction of cyclooxygenase-2 by the activated MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathway. |journal=J. Biol. Chem. |volume=273 |issue= 21 |pages= 12901–8 |year= 1998 |pmid= 9582321 |doi=
*cite journal | author=Su GH, Hilgers W, Shekher MC, "et al." |title=Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. |journal=Cancer Res. |volume=58 |issue= 11 |pages= 2339–42 |year= 1998 |pmid= 9622070 |doi=
*cite journal | author=Yang J, New L, Jiang Y, "et al." |title=Molecular cloning and characterization of a human protein kinase that specifically activates c-Jun N-terminal kinase. |journal=Gene |volume=212 |issue= 1 |pages= 95–102 |year= 1998 |pmid= 9661668 |doi=
*cite journal | author=Widegren U, Jiang XJ, Krook A, "et al." |title=Divergent effects of exercise on metabolic and mitogenic signaling pathways in human skeletal muscle. |journal=FASEB J. |volume=12 |issue= 13 |pages= 1379–89 |year= 1998 |pmid= 9761781 |doi=
*cite journal | author=Xia Y, Wu Z, Su B, "et al." |title=JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. |journal=Genes Dev. |volume=12 |issue= 21 |pages= 3369–81 |year= 1998 |pmid= 9808624 |doi=
*cite journal | author=Chan-Hui PY, Weaver R |title=Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades. |journal=Biochem. J. |volume=336 ( Pt 3) |issue= |pages= 599–609 |year= 1999 |pmid= 9841871 |doi=
*cite journal | author=Merritt SE, Mata M, Nihalani D, "et al." |title=The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10195–202 |year= 1999 |pmid= 10187804 |doi=
*cite journal | author=Orth K, Palmer LE, Bao ZQ, "et al." |title=Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector. |journal=Science |volume=285 |issue= 5435 |pages= 1920–3 |year= 1999 |pmid= 10489373 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes