MAPK8

Mitogen-activated protein kinase 8
PDB rendering based on 1jnk.
Available structures PDB 1UKH, 1UKI, 2G01, 2GMX, 2H96, 2NO3, 3ELJ
Identifiers
Symbols	MAPK8; JNK; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1
External IDs	OMIM: 601158 MGI: 1346861 HomoloGene: 56760 GeneCards: MAPK8 Gene
EC number	2.7.11.24
Gene Ontology Molecular function • nucleotide binding • protein serine/threonine kinase activity • protein serine/threonine kinase activity • JUN kinase activity • JUN kinase activity • MAP kinase activity • protein binding • ATP binding • kinase activity • histone deacetylase regulator activity • histone deacetylase binding Cellular component • nucleus • nucleoplasm • nucleoplasm • cytoplasm • cytosol • cytosol Biological process • ossification • toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • apoptosis • apoptosis • response to stress • JNK cascade • JNK cascade • JUN phosphorylation • JUN phosphorylation • Toll signaling pathway • induction of apoptosis by extracellular signals • induction of apoptosis by intracellular signals • activation of pro-apoptotic gene products • activation of pro-apoptotic gene products • response to UV • phosphorylation • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • peptidyl-threonine phosphorylation • regulation of histone deacetylation • induction of apoptosis in response to chemical stimulus • negative regulation of protein binding • regulation of protein localization • toll-like receptor 1 signaling pathway • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • negative regulation of apoptosis • innate immune response • response to cadmium ion • nerve growth factor receptor signaling pathway • regulation of sequence-specific DNA binding transcription factor activity • stress-activated MAPK cascade • cellular response to mechanical stimulus • positive regulation of deacetylase activity • positive regulation of determination of dorsal identity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5599	26419
Ensembl	ENSG00000107643	ENSMUSG00000021936
UniProt	P45983	Q544A0
RefSeq (mRNA)	NM_002750.2	NM_016700.4
RefSeq (protein)	NP_002741.1	NP_057909.1
Location (UCSC)	Chr 10: 49.51 – 49.65 Mb	Chr 14: 34.19 – 34.26 Mb
PubMed search	[1]	[2]

Mitogen-activated protein kinase 8 is an enzyme that in humans is encoded by the MAPK8 gene.^[1][2]

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha-induced apoptosis. This kinase is also involved in UV radiation-induced apoptosis, which is thought to be related to the cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternately spliced transcript variants encoding distinct isoforms have been reported.^[3]

Interactions

MAPK8 has been shown to interact with SPIB,^[4] DUSP1,^[5] Activating transcription factor 2,^[6][7][8][9] SH3BP5,^[10] GSTP1,^[11] MAPK8IP1,^[12][13] MAP2K7,^[9][14] CRK,^[15] MAP2K4,^{[16][17][8][9][14]} DUSP22,^[18] Myc,^[19] MAP3K2,^[14] DUSP10,^[20] REL,^[21] MAPK8IP3,^[22][23] IRS1,^[24][25] MAP3K1^[26] and C-jun.^{[27][28][1][29][30][21][31][9]}

References

1. ^ ^{a b} Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ (Apr 1994). "JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain". Cell 76 (6): 1025–37. doi:10.1016/0092-8674(94)90380-8. PMID 8137421. 
2. ^ Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Derijard B, Davis RJ (Jul 1996). "Selective interaction of JNK protein kinase isoforms with transcription factors". EMBO J 15 (11): 2760–70. PMC 450211. PMID 8654373. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=450211. 
3. ^ "Entrez Gene: MAPK8 mitogen-activated protein kinase 8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5599. 
4. ^ Mao, C; Ray-Gallet D, Tavitian A, Moreau-Gachelin F (Feb. 1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors". Oncogene (ENGLAND) 12 (4): 863–73. ISSN 0950-9232. PMID 8632909. 
5. ^ Slack, D N; Seternes O M, Gabrielsen M, Keyse S M (May. 2001). "Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1". J. Biol. Chem. (United States) 276 (19): 16491–500. doi:10.1074/jbc.M010966200. ISSN 0021-9258. PMID 11278799. 
6. ^ Raingeaud, J; Gupta S, Rogers J S, Dickens M, Han J, Ulevitch R J, Davis R J (Mar. 1995). "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine". J. Biol. Chem. (UNITED STATES) 270 (13): 7420–6. doi:10.1074/jbc.270.13.7420. ISSN 0021-9258. PMID 7535770. 
7. ^ Fuchs, S Y; Xie B, Adler V, Fried V A, Davis R J, Ronai Z (Dec. 1997). "c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors". J. Biol. Chem. (UNITED STATES) 272 (51): 32163–8. doi:10.1074/jbc.272.51.32163. ISSN 0021-9258. PMID 9405416. 
8. ^ ^{a b} Chen, Z; Cobb M H (May. 2001). "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2". J. Biol. Chem. (United States) 276 (19): 16070–5. doi:10.1074/jbc.M100681200. ISSN 0021-9258. PMID 11279118. 
9. ^ ^{a b c d} Tournier, C; Whitmarsh A J, Cavanagh J, Barrett T, Davis R J (Jul. 1997). "Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (14): 7337–42. doi:10.1073/pnas.94.14.7337. ISSN 0027-8424. PMC 23822. PMID 9207092. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=23822. 
10. ^ Wiltshire, Carolyn; Matsushita Masato, Tsukada Satoshi, Gillespie David A F, May Gerhard H W (Nov. 2002). "A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria". Biochem. J. (England) 367 (Pt 3): 577–85. doi:10.1042/BJ20020553. ISSN 0264-6021. PMC 1222945. PMID 12167088. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222945. 
11. ^ Wang, T; Arifoglu P, Ronai Z, Tew K D (Jun. 2001). "Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus". J. Biol. Chem. (United States) 276 (24): 20999–1003. doi:10.1074/jbc.M101355200. ISSN 0021-9258. PMID 11279197. 
12. ^ Whitmarsh, A J; Cavanagh J, Tournier C, Yasuda J, Davis R J (Sep. 1998). "A mammalian scaffold complex that selectively mediates MAP kinase activation". Science (UNITED STATES) 281 (5383): 1671–4. doi:10.1126/science.281.5383.1671. ISSN 0036-8075. PMID 9733513. 
13. ^ Cai, Yi; Lechner Mark S, Nihalani Deepak, Prindle Marc J, Holzman Lawrence B, Dressler Gregory R (Jan. 2002). "Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation". J. Biol. Chem. (United States) 277 (2): 1217–22. doi:10.1074/jbc.M109663200. ISSN 0021-9258. PMID 11700324. 
14. ^ ^{a b c} Cheng, J; Yang J, Xia Y, Karin M, Su B (Apr. 2000). "Synergistic Interaction of MEK Kinase 2, c-Jun N-Terminal Kinase (JNK) Kinase 2, and JNK1 Results in Efficient and Specific JNK1 Activation". Mol. Cell. Biol. (UNITED STATES) 20 (7): 2334–42. doi:10.1128/MCB.20.7.2334-2342.2000. ISSN 0270-7306. PMC 85399. PMID 10713157. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85399. 
15. ^ Girardin, S E; Yaniv M (Jul. 2001). "A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation". EMBO J. (England) 20 (13): 3437–46. doi:10.1093/emboj/20.13.3437. ISSN 0261-4189. PMC 125507. PMID 11432831. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125507. 
16. ^ Lee, Clement M; Onésime Djamila, Reddy C Damodara, Dhanasekaran N, Reddy E Premkumar (Oct. 2002). "JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (22): 14189–94. doi:10.1073/pnas.232310199. ISSN 0027-8424. PMC 137859. PMID 12391307. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=137859. 
17. ^ Park, Hee-Sae; Kim Mi-Sung, Huh Sung-Ho, Park Jihyun, Chung Jongkyeong, Kang Sang Sun, Choi Eui-Ju (Jan. 2002). "Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation". J. Biol. Chem. (United States) 277 (4): 2573–8. doi:10.1074/jbc.M110299200. ISSN 0021-9258. PMID 11707464. 
18. ^ Aoyama, K; Nagata M, Oshima K, Matsuda T, Aoki N (Jul. 2001). "Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain". J. Biol. Chem. (United States) 276 (29): 27575–83. doi:10.1074/jbc.M100408200. ISSN 0021-9258. PMID 11346645. 
19. ^ Noguchi, K; Kitanaka C, Yamana H, Kokubu A, Mochizuki T, Kuchino Y (Nov. 1999). "Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase". J. Biol. Chem. (UNITED STATES) 274 (46): 32580–7. doi:10.1074/jbc.274.46.32580. ISSN 0021-9258. PMID 10551811. 
20. ^ Tanoue, T; Moriguchi T, Nishida E (Jul. 1999). "Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5". J. Biol. Chem. (UNITED STATES) 274 (28): 19949–56. doi:10.1074/jbc.274.28.19949. ISSN 0021-9258. PMID 10391943. 
21. ^ ^{a b} Meyer, C F; Wang X, Chang C, Templeton D, Tan T H (Apr. 1996). "Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation". J. Biol. Chem. (UNITED STATES) 271 (15): 8971–6. doi:10.1074/jbc.271.15.8971. ISSN 0021-9258. PMID 8621542. 
22. ^ Ito, M; Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto K I (Nov. 1999). "JSAP1, a Novel Jun N-Terminal Protein Kinase (JNK)-Binding Protein That Functions as a Scaffold Factor in the JNK Signaling Pathway". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7539–48. ISSN 0270-7306. PMC 84763. PMID 10523642. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84763. 
23. ^ Kelkar, N; Gupta S, Dickens M, Davis R J (Feb. 2000). "Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3". Mol. Cell. Biol. (UNITED STATES) 20 (3): 1030–43. doi:10.1128/MCB.20.3.1030-1043.2000. ISSN 0270-7306. PMC 85220. PMID 10629060. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85220. 
24. ^ Aguirre, Vincent; Werner Eric D, Giraud Jodel, Lee Yong Hee, Shoelson Steve E, White Morris F (Jan. 2002). "Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action". J. Biol. Chem. (United States) 277 (2): 1531–7. doi:10.1074/jbc.M101521200. ISSN 0021-9258. PMID 11606564. 
25. ^ Aguirre, V; Uchida T, Yenush L, Davis R, White M F (Mar. 2000). "The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)". J. Biol. Chem. (UNITED STATES) 275 (12): 9047–54. doi:10.1074/jbc.275.12.9047. ISSN 0021-9258. PMID 10722755. 
26. ^ Xu, S; Cobb M H (Dec. 1997). "MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases". J. Biol. Chem. (UNITED STATES) 272 (51): 32056–60. doi:10.1074/jbc.272.51.32056. ISSN 0021-9258. PMID 9405400. 
27. ^ Ishitani, Tohru; Takaesu Giichi, Ninomiya-Tsuji Jun, Shibuya Hiroshi, Gaynor Richard B, Matsumoto Kunihiro (Dec. 2003). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling". EMBO J. (England) 22 (23): 6277–88. doi:10.1093/emboj/cdg605. ISSN 0261-4189. PMC 291846. PMID 14633987. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=291846. 
28. ^ Nishitoh, H; Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H (Sep. 1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Mol. Cell (UNITED STATES) 2 (3): 389–95. doi:10.1016/S1097-2765(00)80283-X. ISSN 1097-2765. PMID 9774977. 
29. ^ Yazgan, Oya; Pfarr Curt M (Aug. 2002). "Regulation of two JunD isoforms by Jun N-terminal kinases". J. Biol. Chem. (United States) 277 (33): 29710–8. doi:10.1074/jbc.M204552200. ISSN 0021-9258. PMID 12052834. 
30. ^ Tada, K; Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, Hashimoto H, Mak T W, Yagita H, Okumura K, Yeh W C, Nakano H (Sep. 2001). "Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death". J. Biol. Chem. (United States) 276 (39): 36530–4. doi:10.1074/jbc.M104837200. ISSN 0021-9258. PMID 11479302. 
31. ^ Cano, E; Hazzalin C A, Kardalinou E, Buckle R S, Mahadevan L C (Nov. 1995). "Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction". J. Cell. Sci. (ENGLAND) 108 ( Pt 11): 3599–609. ISSN 0021-9533. PMID 8586671. 

External Links

• MAP Kinase Resource .

Further reading

• Davis RJ (2000). "Signal transduction by the JNK group of MAP kinases". Cell 103 (2): 239–52. doi:10.1016/S0092-8674(00)00116-1. PMID 11057897. 
• Liu J, Lin A (2007). "Wiring the cell signaling circuitry by the NF-kappa B and JNK1 crosstalk and its applications in human diseases". Oncogene 26 (22): 3267–78. doi:10.1038/sj.onc.1210417. PMID 17496921. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transferase article is a stub. You can help Wikipedia by expanding it.v · Categories: Human proteins Cell signaling Signal transduction Transferase stubs EC 2.7.11 Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Order of precedence in Ontario Around the World in 80 Dreams Look at other dictionaries: MAPK8 — MAP quinasa 8 Estructura tridimensional de la proteína MAPK8. HUGO 6881 …   Wikipedia Español MAP kinase kinase kinase — (or MAP3K or MEKK) is a serine/threonine specific protein kinase which acts upon MAP kinase kinase. In humans there are at least 19 genes: MAP3K1 (aka MEKK1) MAP3K2 MAP3K3 (aka MEKK3) MAP3K4 MAP3K5 (aka ASK1) MAP3K6 (aka ASK2) MAP3K7 (aka MEKK7)… …   Wikipedia Mitogen-activated protein kinase — Identifiers EC number 2.7.11.24 CAS number 142243 02 5 …   Wikipedia Mitogen-activated protein kinase 9 — Rendering based on PDB 3E7O …   Wikipedia c-Jun N-terminal kinases — Main article: Mitogen activated protein kinase mitogen activated protein kinase 8 Identifiers Symbol MAPK8 Alt. symbols …   Wikipedia Mitogen-activated protein kinase kinase — For other uses, see MKK (disambiguation). Mitogen activated protein kinase kinase [sic] (also known as MAP2K) is a kinase enzyme which phosphorylates mitogen activated protein kinase (MAPK). MAP2K is classified as EC 2.7.12.2. There are seven… …   Wikipedia SUMO network — consists of enzymes and substrates involved in the dynamic posttranslational modification process of sumoylation (i.e. transfer of SUMO protein to substrates). Network membersThe SUMO network members (gene name and aliases) as published in the… …   Wikipedia Autophagy network — consists of enzymes and substrates involved in the degradation of a cell s own components. Network membersThe Autophagy network members (gene name and aliases) as published in the last 500 newest PubMed entries (see below) are depicted… …   Wikipedia MAPK8IP1 — Mitogen activated protein kinase 8 interacting protein 1, also known as MAPK8IP1, is a human gene. PBB Summary section title = summary text = The protein encoded by this gene is a regulator of the pancreatic beta cell function. It is highly… …   Wikipedia MAP4K4 — Mitogen activated protein kinase kinase kinase kinase 4, also known as MAP4K4, is a human gene.cite web | title = Entrez Gene: MAP4K4 mitogen activated protein kinase kinase kinase kinase 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”