Cyclin-dependent kinase 7

Cyclin-dependent kinase 7
PDB rendering based on 1ua2.
Available structures PDB 1LG3, 1PA8, 1UA2, 2HIC
Identifiers
Symbols	CDK7; CAK1; CDKN7; MO15; STK1; p39MO15
External IDs	OMIM: 601955 MGI: 102956 HomoloGene: 1363 GeneCards: CDK7 Gene
Gene Ontology Molecular function • nucleotide binding • transcription coactivator activity • protein kinase activity • cyclin-dependent protein kinase activity • ATP binding • protein C-terminus binding • DNA-dependent ATPase activity • RNA polymerase II carboxy-terminal domain kinase activity • kinase activity • protein complex binding • androgen receptor binding Cellular component • membrane fraction • nucleus • nucleoplasm • nucleoplasm • holo TFIIH complex • cytoplasm • mitochondrion • cytosol • cytoskeleton Biological process • regulation of cyclin-dependent protein kinase activity • G1 phase of mitotic cell cycle • G1/S transition of mitotic cell cycle • S phase of mitotic cell cycle • G2/M transition of mitotic cell cycle • mitotic cell cycle • nucleotide-excision repair, DNA damage removal • DNA repair • transcription-coupled nucleotide-excision repair • nucleotide-excision repair • transcription from RNA polymerase I promoter • transcription initiation from RNA polymerase I promoter • transcription elongation from RNA polymerase I promoter • termination of RNA polymerase I transcription • transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • mRNA capping • protein phosphorylation • protein phosphorylation • cell proliferation • gene expression • viral reproduction • phosphorylation • androgen receptor signaling pathway • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • positive regulation of viral transcription • cell division Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1022	12572
Ensembl	ENSG00000134058	ENSMUSG00000069089
UniProt	P50613	Q3THG5
RefSeq (mRNA)	NM_001799.3	NM_009874.3
RefSeq (protein)	NP_001790.1	NP_034004.2
Location (UCSC)	Chr 5: 68.57 – 68.61 Mb	Chr 13: 101.47 – 101.5 Mb
PubMed search	[1]	[2]

Cell division protein kinase 7 is an enzyme that in humans is encoded by the CDK7 gene.^[1]

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.^[2]

Interactions

Cyclin-dependent kinase 7 has been shown to interact with XPB,^[3][4][5] Cyclin H,^[6][5][7] P53,^[8][9] Androgen receptor,^[10] GTF2H1,^[4][11][5] MNAT1^[12][5] and SUPT5H.^[7]

See also

• Cyclin-dependent kinase
• CDK7 pathway

References

1. ^ Fisher RP, Morgan DO (Sep 1994). "A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase". Cell 78 (4): 713–24. doi:10.1016/0092-8674(94)90535-5. PMID 8069918. 
2. ^ "Entrez Gene: CDK7 cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1022. 
3. ^ Giglia-Mari, Giuseppina; Coin Frederic, Ranish Jeffrey A, Hoogstraten Deborah, Theil Arjan, Wijgers Nils, Jaspers Nicolaas G J, Raams Anja, Argentini Manuela, van der Spek P J, Botta Elena, Stefanini Miria, Egly Jean-Marc, Aebersold Ruedi, Hoeijmakers Jan H J, Vermeulen Wim (Jul. 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A". Nat. Genet. (United States) 36 (7): 714–9. doi:10.1038/ng1387. ISSN 1061-4036. PMID 15220921. 
4. ^ ^{a b} Rossignol, M; Kolb-Cheynel I, Egly J M (Apr. 1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH". EMBO J. (ENGLAND) 16 (7): 1628–37. doi:10.1093/emboj/16.7.1628. ISSN 0261-4189. PMC 1169767. PMID 9130708. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169767. 
5. ^ ^{a b c d} Yee, A; Nichols M A, Wu L, Hall F L, Kobayashi R, Xiong Y (Dec. 1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res. (UNITED STATES) 55 (24): 6058–62. ISSN 0008-5472. PMID 8521393. 
6. ^ Mäkelä, T P; Tassan J P, Nigg E A, Frutiger S, Hughes G J, Weinberg R A (Sep. 1994). "A cyclin associated with the CDK-activating kinase MO15". Nature (ENGLAND) 371 (6494): 254–7. doi:10.1038/371254a0. ISSN 0028-0836. PMID 8078587. 
7. ^ ^{a b} Garber, M E; Mayall T P, Suess E M, Meisenhelder J, Thompson N E, Jones K A (Sep. 2000). "CDK9 Autophosphorylation Regulates High-Affinity Binding of the Human Immunodeficiency Virus Type 1 Tat–P-TEFb Complex to TAR RNA". Mol. Cell. Biol. (UNITED STATES) 20 (18): 6958–69. doi:10.1128/MCB.20.18.6958-6969.2000. ISSN 0270-7306. PMC 88771. PMID 10958691. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=88771. 
8. ^ Ko, L J; Shieh S Y, Chen X, Jayaraman L, Tamai K, Taya Y, Prives C, Pan Z Q (Dec. 1997). "p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner". Mol. Cell. Biol. (UNITED STATES) 17 (12): 7220–9. ISSN 0270-7306. PMC 232579. PMID 9372954. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232579. 
9. ^ Schneider, E; Montenarh M, Wagner P (Nov. 1998). "Regulation of CAK kinase activity by p53". Oncogene (ENGLAND) 17 (21): 2733–41. doi:10.1038/sj.onc.1202504. ISSN 0950-9232. PMID 9840937. 
10. ^ Lee, D K; Duan H O, Chang C (Mar. 2000). "From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator". J. Biol. Chem. (UNITED STATES) 275 (13): 9308–13. doi:10.1074/jbc.275.13.9308. ISSN 0021-9258. PMID 10734072. 
11. ^ Shiekhattar, R; Mermelstein F, Fisher R P, Drapkin R, Dynlacht B, Wessling H C, Morgan D O, Reinberg D (Mar. 1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH". Nature (ENGLAND) 374 (6519): 283–7. doi:10.1038/374283a0. ISSN 0028-0836. PMID 7533895. 
12. ^ Talukder, Amjad H; Mishra Sandip K, Mandal Mahitosh, Balasenthil Seetharaman, Mehta Sonal, Sahin Aysegul A, Barnes Christopher J, Kumar Rakesh (Mar. 2003). "MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions". J. Biol. Chem. (United States) 278 (13): 11676–85. doi:10.1074/jbc.M209570200. ISSN 0021-9258. PMID 12527756. 

Further reading

• Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7. doi:10.1007/BF02253352. PMID 9570510. 
• Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447–9. doi:10.1016/S0960-9822(98)70289-1. PMID 9651670. 
• Shiekhattar R, Mermelstein F, Fisher RP, et al. (1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH". Nature 374 (6519): 283–7. doi:10.1038/374283a0. PMID 7533895. 
• Aprelikova O, Xiong Y, Liu ET (1995). "Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase". J. Biol. Chem. 270 (31): 18195–7. doi:10.1074/jbc.270.31.18195. PMID 7629134. 
• Serizawa H, Mäkelä TP, Conaway JW, et al. (1995). "Association of Cdk-activating kinase subunits with transcription factor TFIIH". Nature 374 (6519): 280–2. doi:10.1038/374280a0. PMID 7885450. 
• Tassan JP, Schultz SJ, Bartek J, Nigg EA (1994). "Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase)". J. Cell Biol. 127 (2): 467–78. doi:10.1083/jcb.127.2.467. PMC 2120215. PMID 7929589. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120215. 
• Darbon JM, Devault A, Taviaux S, et al. (1994). "Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase". Oncogene 9 (11): 3127–38. PMID 7936635. 
• Williams RT, Wu L, Carbonaro-Hall DA, Hall FL (1994). "Identification, assay, and purification of a Cdc2-activating threonine-161 protein kinase from human cells". Arch. Biochem. Biophys. 314 (1): 99–106. doi:10.1006/abbi.1994.1416. PMID 7944411. 
• Mäkelä TP, Tassan JP, Nigg EA, et al. (1994). "A cyclin associated with the CDK-activating kinase MO15". Nature 371 (6494): 254–7. doi:10.1038/371254a0. PMID 8078587. 
• Levedakou EN, He M, Baptist EW, et al. (1994). "Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern". Oncogene 9 (7): 1977–88. PMID 8208544. 
• Wu L, Yee A, Liu L, et al. (1994). "Molecular cloning of the human CAK1 gene encoding a cyclin-dependent kinase-activating kinase". Oncogene 9 (7): 2089–96. PMID 8208556. 
• Yee A, Nichols MA, Wu L, et al. (1996). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res. 55 (24): 6058–62. PMID 8521393. 
• Blau J, Xiao H, McCracken S, et al. (1996). "Three functional classes of transcriptional activation domain". Mol. Cell. Biol. 16 (5): 2044–55. PMC 231191. PMID 8628270. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231191. 
• Bartkova J, Zemanova M, Bartek J (1996). "Expression of CDK7/CAK in normal and tumor cells of diverse histogenesis, cell-cycle position and differentiation". Int. J. Cancer 66 (6): 732–7. doi:10.1002/(SICI)1097-0215(19960611)66:6<732::AID-IJC4>3.0.CO;2-0. PMID 8647641. 
• Reardon JT, Ge H, Gibbs E, et al. (1996). "Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6482–7. doi:10.1073/pnas.93.13.6482. PMC 39049. PMID 8692841. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=39049. 
• Drapkin R, Le Roy G, Cho H, et al. (1996). "Human cyclin-dependent kinase-activating kinase exists in three distinct complexes". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6488–93. doi:10.1073/pnas.93.13.6488. PMC 39050. PMID 8692842. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=39050. 
• Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science 274 (5287): 605–10. doi:10.1126/science.274.5287.605. PMID 8849451. 
• Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature 384 (6607): 375–8. doi:10.1038/384375a0. PMID 8934526. 
• García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem. 272 (11): 6951–8. doi:10.1074/jbc.272.11.6951. PMID 9054383. 

External links

• MeSH CDK7+protein,+human

B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)