PRKAG3

Protein kinase, AMP-activated, gamma 3 non-catalytic subunit, also known as PRKAG3, is a human gene.cite web | title = Entrez Gene: PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53632| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle.cite web | title = Entrez Gene: PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53632| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Woods A, Cheung PC, Smith FC, "et al." |title=Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro. |journal=J. Biol. Chem. |volume=271 |issue= 17 |pages= 10282–90 |year= 1996 |pmid= 8626596 |doi=
*cite journal | author=Cheung PC, Salt IP, Davies SP, "et al." |title=Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. |journal=Biochem. J. |volume=346 Pt 3 |issue= |pages= 659–69 |year= 2000 |pmid= 10698692 |doi=
*cite journal | author=Milan D, Jeon JT, Looft C, "et al." |title=A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle. |journal=Science |volume=288 |issue= 5469 |pages= 1248–51 |year= 2000 |pmid= 10818001 |doi=
*cite journal | author=Nielsen JN, Mustard KJ, Graham DA, "et al." |title=5'-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle. |journal=J. Appl. Physiol. |volume=94 |issue= 2 |pages= 631–41 |year= 2003 |pmid= 12391032 |doi= 10.1152/japplphysiol.00642.2002
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Jeon JT, Park EW, Jeon HJ, "et al." |title=A large-insert porcine library with sevenfold genome coverage: a tool for positional cloning of candidate genes for major quantitative traits. |journal=Mol. Cells |volume=16 |issue= 1 |pages= 113–6 |year= 2004 |pmid= 14503854 |doi=
*cite journal | author=Mahlapuu M, Johansson C, Lindgren K, "et al." |title=Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle. |journal=Am. J. Physiol. Endocrinol. Metab. |volume=286 |issue= 2 |pages= E194–200 |year= 2004 |pmid= 14559719 |doi= 10.1152/ajpendo.00147.2003
*cite journal | author=Amarger V, Erlandsson R, Pielberg G, "et al." |title=Comparative sequence analysis of the PRKAG3 region between human and pig: evolution of repetitive sequences and potential new exons. |journal=Cytogenet. Genome Res. |volume=102 |issue= 1-4 |pages= 163–72 |year= 2003 |pmid= 14970697 |doi= 10.1159/000075743
*cite journal | author=Park HB, Marklund S, Jeon JT, "et al." |title=Molecular characterization and mutational screening of the PRKAG3 gene in the horse. |journal=Cytogenet. Genome Res. |volume=102 |issue= 1-4 |pages= 211-16 |year= 2003 |pmid= 14970705 |doi= 10.1159/000075751
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Barnes BR, Long YC, Steiler TL, "et al." |title=Changes in exercise-induced gene expression in 5'-AMP-activated protein kinase gamma3-null and gamma3 R225Q transgenic mice. |journal=Diabetes |volume=54 |issue= 12 |pages= 3484–9 |year= 2006 |pmid= 16306365 |doi=
*cite journal | author=Lindgren K, Ormestad M, Persson M, "et al." |title=Regulation of the muscle-specific AMP-activated protein kinase alpha2beta2gamma3 complexes by AMP and implications of the mutations in the gamma3-subunit for the AMP dependence of the enzyme. |journal=FEBS J. |volume=274 |issue= 11 |pages= 2887–96 |year= 2007 |pmid= 17518971 |doi= 10.1111/j.1742-4658.2007.05821.x

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