MYO3A

MYO3A

Myosin IIIA, also known as MYO3A, is a human gene.cite web | title = Entrez Gene: MYO3A myosin IIIA| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53904| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea.cite web | title = Entrez Gene: MYO3A myosin IIIA| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53904| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dosé AC, Burnside B |title=Cloning and chromosomal localization of a human class III myosin. |journal=Genomics |volume=67 |issue= 3 |pages= 333–42 |year= 2000 |pmid= 10936054 |doi= 10.1006/geno.2000.6256
*cite journal | author=Walsh T, Walsh V, Vreugde S, "et al." |title=From flies' eyes to our ears: mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 11 |pages= 7518–23 |year= 2002 |pmid= 12032315 |doi= 10.1073/pnas.102091699
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Komaba S, Inoue A, Maruta S, "et al." |title=Determination of human myosin III as a motor protein having a protein kinase activity. |journal=J. Biol. Chem. |volume=278 |issue= 24 |pages= 21352–60 |year= 2003 |pmid= 12672820 |doi= 10.1074/jbc.M300757200
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462
*cite journal | author=Fu GK, Wang JT, Yang J, "et al." |title=Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. |journal=Genomics |volume=84 |issue= 1 |pages= 205–10 |year= 2005 |pmid= 15203218 |doi= 10.1016/j.ygeno.2004.01.011
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, "et al." |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776
*cite journal | author=Kambara T, Komaba S, Ikebe M |title=Human myosin III is a motor having an extremely high affinity for actin. |journal=J. Biol. Chem. |volume=281 |issue= 49 |pages= 37291–301 |year= 2007 |pmid= 17012748 |doi= 10.1074/jbc.M603823200
*cite journal | author=Schneider ME, Dosé AC, Salles FT, "et al." |title=A new compartment at stereocilia tips defined by spatial and temporal patterns of myosin IIIa expression. |journal=J. Neurosci. |volume=26 |issue= 40 |pages= 10243–52 |year= 2006 |pmid= 17021180 |doi= 10.1523/JNEUROSCI.2812-06.2006
*cite journal | author=Dosé AC, Ananthanarayanan S, Moore JE, "et al." |title=Kinetic mechanism of human myosin IIIA. |journal=J. Biol. Chem. |volume=282 |issue= 1 |pages= 216–31 |year= 2007 |pmid= 17074769 |doi= 10.1074/jbc.M605964200

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