P38 mitogen-activated protein kinases
- P38 mitogen-activated protein kinases
protein
Name = mitogen-activated protein kinase 11
caption =
width =
HGNCid = 6873
Symbol = MAPK11
AltSymbols = PRKM11
EntrezGene = 5600
OMIM = 602898
RefSeq = NM_002751
UniProt = Q15759
PDB =
ECnumber =
Chromosome = 22
Arm =
Band =
LocusSupplementaryData = protein
Name = mitogen-activated protein kinase 12
caption =
width =
HGNCid = 6874
Symbol = MAPK12
AltSymbols = SAPK3
EntrezGene = 6300
OMIM = 602399
RefSeq = NM_002969
UniProt = P53778
PDB =
ECnumber =
Chromosome = 22
Arm = q
Band = 13.3
LocusSupplementaryData = protein
Name = mitogen-activated protein kinase 13
caption =
width =
HGNCid = 6875
Symbol = MAPK13
AltSymbols = PRKM13
EntrezGene = 5603
OMIM = 602899
RefSeq = NM_002754
UniProt = O15264
PDB =
ECnumber =
Chromosome = 6
Arm = p
Band = 21
LocusSupplementaryData = protein
Name = mitogen-activated protein kinase 14
caption =
width =
HGNCid = 6876
Symbol = MAPK14
AltSymbols = CSPB1, CSBP1, CSBP2
EntrezGene = 1432
OMIM = 600289
RefSeq = NM_001315
UniProt = Q16539
PDB =
ECnumber =
Chromosome = 6
Arm = p
Band = 21.3-21.2
LocusSupplementaryData =
P38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases which are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation and apoptosis.
p38 MAP Kinase (MAPK), also called RK or CSBP, is the mammalian orthologue of the yeast HOG kinase which participates in a signalling cascade controlling cellular responses to cytokines and stress.
Four isoforms of p38 MAP kinase, p38-α(MAPK14), -β(MAPK11), -γ (MAPK12 or ERK6) and -δ(MAPK13 or SAPK4) have been identified. Similar to the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), Ultraviolet light and growth factors.
MKK3 and SEK activate p38 MAP kinase by phosphorylation at Thr180 and Tyr182, Activated p38 MAP kinase has been shown to phosphorylate and activate MAPKAP kinase 2 and to phosphorylate the transcription factors ATF-2, Mac and MEF2.
External links
*MeshName|p38+Mitogen-Activated+Protein+Kinases
* [http://www.biocarta.com/pathfiles/m_p38mapkPathway.asp P38mapkPathway]
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