MAPK14

Mitogen-activated protein kinase 14, also known as MAPK14, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [cite web | title = Entrez Gene: MAPK14 mitogen-activated protein kinase 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1432| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ben-Levy R, Hooper S, Wilson R, "et al." |title=Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. |journal=Curr. Biol. |volume=8 |issue= 19 |pages= 1049–57 |year= 1999 |pmid= 9768359 |doi=
*cite journal | author=Bradham C, McClay DR |title=p38 MAPK in development and cancer. |journal=Cell Cycle |volume=5 |issue= 8 |pages= 824–8 |year= 2006 |pmid= 16627995 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes