TRIB3

TRIB3

Tribbles homolog 3 (Drosophila), also known as TRIB3, is a human gene.cite web | title = Entrez Gene: TRIB3 tribbles homolog 3 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57761| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1.cite web | title = Entrez Gene: TRIB3 tribbles homolog 3 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57761| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hegedus Z, Czibula A, Kiss-Toth E |title=Tribbles: novel regulators of cell function; evolutionary aspects. |journal=Cell. Mol. Life Sci. |volume=63 |issue= 14 |pages= 1632–41 |year= 2006 |pmid= 16715410 |doi= 10.1007/s00018-006-6007-9
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wu M, Xu LG, Zhai Z, Shu HB |title=SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription. |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 27072–9 |year= 2003 |pmid= 12736262 |doi= 10.1074/jbc.M209814200
*cite journal | author=Bowers AJ, Scully S, Boylan JF |title=SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia. |journal=Oncogene |volume=22 |issue= 18 |pages= 2823–35 |year= 2003 |pmid= 12743605 |doi= 10.1038/sj.onc.1206367
*cite journal | author=Du K, Herzig S, Kulkarni RN, Montminy M |title=TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. |journal=Science |volume=300 |issue= 5625 |pages= 1574–7 |year= 2003 |pmid= 12791994 |doi= 10.1126/science.1079817
*cite journal | author=Huang J, Teng L, Liu T, "et al." |title=Identification of a novel serine/threonine kinase that inhibits TNF-induced NF-kappaB activation and p53-induced transcription. |journal=Biochem. Biophys. Res. Commun. |volume=309 |issue= 4 |pages= 774–8 |year= 2003 |pmid= 13679039 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Kiss-Toth E, Bagstaff SM, Sung HY, "et al." |title=Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. |journal=J. Biol. Chem. |volume=279 |issue= 41 |pages= 42703–8 |year= 2004 |pmid= 15299019 |doi= 10.1074/jbc.M407732200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ohoka N, Yoshii S, Hattori T, "et al." |title=TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. |journal=EMBO J. |volume=24 |issue= 6 |pages= 1243–55 |year= 2005 |pmid= 15775988 |doi= 10.1038/sj.emboj.7600596
*cite journal | author=Ord D, Ord T |title=Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions. |journal=Biochem. Biophys. Res. Commun. |volume=330 |issue= 1 |pages= 210–8 |year= 2005 |pmid= 15781252 |doi= 10.1016/j.bbrc.2005.02.149
*cite journal | author=Prudente S, Hribal ML, Flex E, "et al." |title=The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy. |journal=Diabetes |volume=54 |issue= 9 |pages= 2807–11 |year= 2005 |pmid= 16123373 |doi=
*cite journal | author=Schwarzer R, Dames S, Tondera D, "et al." |title=TRB3 is a PI 3-kinase dependent indicator for nutrient starvation. |journal=Cell. Signal. |volume=18 |issue= 6 |pages= 899–909 |year= 2006 |pmid= 16129579 |doi= 10.1016/j.cellsig.2005.08.002
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029
*cite journal | author=Matsushima R, Harada N, Webster NJ, "et al." |title=Effect of TRB3 on insulin and nutrient-stimulated hepatic p70 S6 kinase activity. |journal=J. Biol. Chem. |volume=281 |issue= 40 |pages= 29719–29 |year= 2006 |pmid= 16887816 |doi= 10.1074/jbc.M511636200
*cite journal | author=Koh HJ, Arnolds DE, Fujii N, "et al." |title=Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. |journal=Mol. Cell. Biol. |volume=26 |issue= 22 |pages= 8217–27 |year= 2007 |pmid= 16966378 |doi= 10.1128/MCB.00979-06

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