IκB kinase

protein
Name = conserved helix-loop-helix ubiquitous kinase
caption =


width =
HGNCid = 1974
Symbol = CHUK
AltSymbols = TCF16
EntrezGene = 1147
OMIM = 600664
RefSeq = NM_001278
UniProt = O15111
PDB =
ECnumber = 2.7.11.10
Chromosome = 10
Arm = q
Band = 24
LocusSupplementaryData = -q25protein
Name = inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
caption =


width =
HGNCid = 5960
Symbol = IKBKB
AltSymbols =
EntrezGene = 3551
OMIM = 603258
RefSeq = NM_001556
UniProt = O14920
PDB =
ECnumber = 2.7.11.10
Chromosome = 8
Arm = p
Band = 11.2
LocusSupplementaryData = protein
Name = inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
caption =


width =
HGNCid = 5961
Symbol = IKBKG
AltSymbols = IP2, IP1
EntrezGene = 8517
OMIM = 300248
RefSeq = NM_003639
UniProt = Q9Y6K9
PDB =
ECnumber =
Chromosome = X
Arm = q
Band = 28
LocusSupplementaryData =

The IκB kinase (IKK) enzyme complex is part of the upstream NF-κB signal transduction cascade. The IκBα (inhibitor of kappa B) protein inactivates the NF-κB transcription factor by masking the nuclear localization signals (NLS) of NF-κB proteins and keep them sequestered in an inactive state in the cytoplasm.cite journal | author = Jacobs MD, Harrison SC | title = Structure of an IkappaBalpha/NF-kappaB complex | journal = Cell | volume = 95 | issue = 6 | pages = 749–58 | year = 1998 | pmid = 9865693 | doi = 10.1016/S0092-8674(00)81698-0 | issn = ] cite journal | author = Régnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M | title = Identification and characterization of an IkappaB kinase | journal = Cell | volume = 90 | issue = 2 | pages = 373–83 | year = 1997 | pmid = 9244310 | doi = 10.1016/S0092-8674(00)80344-X | issn = ] cite journal | author = Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, Li J, Young DB, Barbosa M, Mann M, Manning A, Rao A | title = IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation | journal = Science | volume = 278 | issue = 5339 | pages = 860–6 | year = 1997 | pmid = 9346484 | doi = 10.1126/science.278.5339.860 | issn = ] IKK specifically phosphorylates the inhibitory IκBα protein.cite journal | author = Karin M | title = How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex | journal = Oncogene | volume = 18 | issue = 49 | pages = 6867–74 | year = 1999 | pmid = 10602462 | doi = 10.1038/sj.onc.1203219 | issn = ] This phosphorylation results in the dissociation of IκBα from NF-κB and thereby activates NF-κB.

tructure

The IκB kinase complex is comprised of three subunits each encoded by a separate gene:
* IKKα (also known as IKK1) (gene|CHUK)
* IKKβ (also known as IKK2) (gene|IKBKB)
* IKKγ (also known as NEMO) (gene|IKBKG)The α- and β-subunits together are catalytically active whereas the γ-subunit serves a regulatory function.

References

External links

*