EEF2K

EEF2K

Eukaryotic elongation factor-2 kinase, also known as EEF2K, is an enzyme.cite web | title = Entrez Gene: EEF2K eukaryotic elongation factor-2 kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29904| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment.cite web | title = Entrez Gene: EEF2K eukaryotic elongation factor-2 kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29904| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nairn AC, Palfrey HC |title=Identification of the major Mr 100,000 substrate for calmodulin-dependent protein kinase III in mammalian cells as elongation factor-2. |journal=J. Biol. Chem. |volume=262 |issue= 36 |pages= 17299–303 |year= 1988 |pmid= 3693353 |doi=
*cite journal | author=Redpath NT, Price NT, Severinov KV, Proud CG |title=Regulation of elongation factor-2 by multisite phosphorylation. |journal=Eur. J. Biochem. |volume=213 |issue= 2 |pages= 689–99 |year= 1993 |pmid= 8386634 |doi=
*cite journal | author=Ryazanov AG, Ward MD, Mendola CE, "et al." |title=Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 10 |pages= 4884–9 |year= 1997 |pmid= 9144159 |doi=
*cite journal | author=Pavur KS, Petrov AN, Ryazanov AG |title=Mapping the functional domains of elongation factor-2 kinase. |journal=Biochemistry |volume=39 |issue= 40 |pages= 12216–24 |year= 2000 |pmid= 11015200 |doi=
*cite journal | author=Diggle TA, Subkhankulova T, Lilley KS, "et al." |title=Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity. |journal=Biochem. J. |volume=353 |issue= Pt 3 |pages= 621–6 |year= 2001 |pmid= 11171059 |doi=
*cite journal | author=Knebel A, Morrice N, Cohen P |title=A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta. |journal=EMBO J. |volume=20 |issue= 16 |pages= 4360–9 |year= 2001 |pmid= 11500363 |doi= 10.1093/emboj/20.16.4360
*cite journal | author=Wang X, Li W, Williams M, "et al." |title=Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. |journal=EMBO J. |volume=20 |issue= 16 |pages= 4370–9 |year= 2001 |pmid= 11500364 |doi= 10.1093/emboj/20.16.4370
*cite journal | author=Arora S, Yang JM, Craft J, Hait W |title=Detection of anti-elongation factor 2 kinase (calmodulin-dependent protein kinase III) antibodies in patients with systemic lupus erythematosus. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 3 |pages= 1073–6 |year= 2002 |pmid= 12051769 |doi= 10.1016/S0006-291X(02)00324-8
*cite journal | author=Wistow G, Bernstein SL, Wyatt MK, "et al." |title=Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. |journal=Mol. Vis. |volume=8 |issue= |pages= 205–20 |year= 2002 |pmid= 12107410 |doi=
*cite journal | author=Knebel A, Haydon CE, Morrice N, Cohen P |title=Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways. |journal=Biochem. J. |volume=367 |issue= Pt 2 |pages= 525–32 |year= 2002 |pmid= 12171600 |doi= 10.1042/BJ20020916
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Browne GJ, Finn SG, Proud CG |title=Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12220–31 |year= 2004 |pmid= 14709557 |doi= 10.1074/jbc.M309773200
*cite journal | author=Browne GJ, Proud CG |title=A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin. |journal=Mol. Cell. Biol. |volume=24 |issue= 7 |pages= 2986–97 |year= 2004 |pmid= 15024086 |doi=
*cite journal | author=Brill LM, Salomon AR, Ficarro SB, "et al." |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d
*cite journal | author=Li X, Alafuzoff I, Soininen H, "et al." |title=Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain. |journal=FEBS J. |volume=272 |issue= 16 |pages= 4211–20 |year= 2005 |pmid= 16098202 |doi= 10.1111/j.1742-4658.2005.04833.x
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Hait WN, Wu H, Jin S, Yang JM |title=Elongation factor-2 kinase: its role in protein synthesis and autophagy. |journal=Autophagy |volume=2 |issue= 4 |pages= 294–6 |year= 2007 |pmid= 16921268 |doi=
*cite journal | author=Beausoleil SA, Villén J, Gerber SA, "et al." |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026

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