FHOD1

Formin homology 2 domain containing 1, also known as FHOD1, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines.cite web | title = Entrez Gene: FHOD1 formin homology 2 domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29109| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Westendorf JJ, Mernaugh R, Hiebert SW |title=Identification and characterization of a protein containing formin homology (FH1/FH2) domains. |journal=Gene |volume=232 |issue= 2 |pages= 173–82 |year= 1999 |pmid= 10352228 |doi=10.1016/S0378-1119(99)00127-4
*cite journal | author=Westendorf JJ |title=The formin/diaphanous-related protein, FHOS, interacts with Rac1 and activates transcription from the serum response element. |journal=J. Biol. Chem. |volume=276 |issue= 49 |pages= 46453–9 |year= 2002 |pmid= 11590143 |doi= 10.1074/jbc.M105162200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Koka S, Neudauer CL, Li X, "et al." |title=The formin-homology-domain-containing protein FHOD1 enhances cell migration. |journal=J. Cell. Sci. |volume=116 |issue= Pt 9 |pages= 1745–55 |year= 2004 |pmid= 12665555 |doi=10.1242/jcs.00386
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Tojo H, Kaieda I, Hattori H, "et al." |title=The Formin family protein, formin homolog overexpressed in spleen, interacts with the insulin-responsive aminopeptidase and profilin IIa. |journal=Mol. Endocrinol. |volume=17 |issue= 7 |pages= 1216–29 |year= 2004 |pmid= 12677009 |doi= 10.1210/me.2003-0056
*cite journal | author=Takeya R, Sumimoto H |title=Fhos, a mammalian formin, directly binds to F-actin via a region N-terminal to the FH1 domain and forms a homotypic complex via the FH2 domain to promote actin fiber formation. |journal=J. Cell. Sci. |volume=116 |issue= Pt 22 |pages= 4567–75 |year= 2004 |pmid= 14576350 |doi= 10.1242/jcs.00769
*cite journal | author=Lehner B, Semple JI, Brown SE, "et al." |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=10.1016/S0888-7543(03)00235-0
*cite journal | author=Katoh M, Katoh M |title=Identification and characterization of human FHOD3 gene in silico. |journal=Int. J. Mol. Med. |volume=13 |issue= 4 |pages= 615–20 |year= 2004 |pmid= 15010865 |doi=
*cite journal | author=Wang Y, El-Zaru MR, Surks HK, Mendelsohn ME |title=Formin homology domain protein (FHOD1) is a cyclic GMP-dependent protein kinase I-binding protein and substrate in vascular smooth muscle cells. |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24420–6 |year= 2004 |pmid= 15051728 |doi= 10.1074/jbc.M313823200
*cite journal | author=Westendorf JJ, Koka S |title=Identification of FHOD1-binding proteins and mechanisms of FHOD1-regulated actin dynamics. |journal=J. Cell. Biochem. |volume=92 |issue= 1 |pages= 29–41 |year= 2004 |pmid= 15095401 |doi= 10.1002/jcb.20031
*cite journal | author=Gill MB, Roecklein-Canfield J, Sage DR, "et al." |title=EBV attachment stimulates FHOS/FHOD1 redistribution and co-aggregation with CD21: formin interactions with the cytoplasmic domain of human CD21. |journal=J. Cell. Sci. |volume=117 |issue= Pt 13 |pages= 2709–20 |year= 2005 |pmid= 15138285 |doi= 10.1242/jcs.01113
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Madrid R, Gasteier JE, Bouchet J, "et al." |title=Oligomerization of the diaphanous-related formin FHOD1 requires a coiled-coil motif critical for its cytoskeletal and transcriptional activities. |journal=FEBS Lett. |volume=579 |issue= 2 |pages= 441–8 |year= 2005 |pmid= 15642356 |doi= 10.1016/j.febslet.2004.12.009
*cite journal | author=Gasteier JE, Schroeder S, Muranyi W, "et al." |title=FHOD1 coordinates actin filament and microtubule alignment to mediate cell elongation. |journal=Exp. Cell Res. |volume=306 |issue= 1 |pages= 192–202 |year= 2005 |pmid= 15878344 |doi= 10.1016/j.yexcr.2005.02.006
*cite journal | author=Boehm MB, Milius TJ, Zhou Y, "et al." |title=The mammalian formin FHOD1 interacts with the ERK MAP kinase pathway. |journal=Biochem. Biophys. Res. Commun. |volume=335 |issue= 4 |pages= 1090–4 |year= 2005 |pmid= 16112087 |doi= 10.1016/j.bbrc.2005.07.191
*cite journal | author=Schönichen A, Alexander M, Gasteier JE, "et al." |title=Biochemical characterization of the diaphanous autoregulatory interaction in the formin homology protein FHOD1. |journal=J. Biol. Chem. |volume=281 |issue= 8 |pages= 5084–93 |year= 2006 |pmid= 16361249 |doi= 10.1074/jbc.M509226200

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