ACF (gene)

Apobec-1 complementation factor, also known as ACF, is a human gene.cite web | title = Entrez Gene: ACF apobec-1 complementation factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29974| accessdate = ]

PBB_Summary
section_title =
summary_text = Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described. Additional splicing has been observed but the full-length nature of these variants has not been determined.cite web | title = Entrez Gene: ACF apobec-1 complementation factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29974| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chester A, Scott J, Anant S, Navaratnam N |title=RNA editing: cytidine to uridine conversion in apolipoprotein B mRNA. |journal=Biochim. Biophys. Acta |volume=1494 |issue= 1-2 |pages= 1–13 |year= 2000 |pmid= 11072063 |doi=
*cite journal | author=Mehta A, Kinter MT, Sherman NE, Driscoll DM |title=Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1846–54 |year= 2000 |pmid= 10669759 |doi=
*cite journal | author=Lellek H, Kirsten R, Diehl I, "et al." |title=Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19848–56 |year= 2000 |pmid= 10781591 |doi= 10.1074/jbc.M001786200
*cite journal | author=Yang Y, Sowden MP, Smith HC |title=Induction of cytidine to uridine editing on cytoplasmic apolipoprotein B mRNA by overexpressing APOBEC-1. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 22663–9 |year= 2000 |pmid= 10833526 |doi= 10.1074/jbc.M910406199
*cite journal | author=Blanc V, Navaratnam N, Henderson JO, "et al." |title=Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing. |journal=J. Biol. Chem. |volume=276 |issue= 13 |pages= 10272–83 |year= 2001 |pmid= 11134005 |doi= 10.1074/jbc.M006435200
*cite journal | author=Harrington JJ, Sherf B, Rundlett S, "et al." |title=Creation of genome-wide protein expression libraries using random activation of gene expression. |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440–5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107
*cite journal | author=Lau PP, Chang BH, Chan L |title=Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome. |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 4 |pages= 977–83 |year= 2001 |pmid= 11352648 |doi= 10.1006/bbrc.2001.4679
*cite journal | author=Blanc V, Henderson JO, Kennedy S, Davidson NO |title=Mutagenesis of apobec-1 complementation factor reveals distinct domains that modulate RNA binding, protein-protein interaction with apobec-1, and complementation of C to U RNA-editing activity. |journal=J. Biol. Chem. |volume=276 |issue= 49 |pages= 46386–93 |year= 2002 |pmid= 11571303 |doi= 10.1074/jbc.M107654200
*cite journal | author=Anant S, Henderson JO, Mukhopadhyay D, "et al." |title=Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor. |journal=J. Biol. Chem. |volume=276 |issue= 50 |pages= 47338–51 |year= 2002 |pmid= 11577082 |doi= 10.1074/jbc.M104911200
*cite journal | author=Henderson JO, Blanc V, Davidson NO |title=Isolation, characterization and developmental regulation of the human apobec-1 complementation factor (ACF) gene. |journal=Biochim. Biophys. Acta |volume=1522 |issue= 1 |pages= 22–30 |year= 2001 |pmid= 11718896 |doi=
*cite journal | author=Xu XR, Huang J, Xu ZG, "et al." |title=Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15089–94 |year= 2002 |pmid= 11752456 |doi= 10.1073/pnas.241522398
*cite journal | author=Dance GS, Sowden MP, Cartegni L, "et al." |title=Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 12703–9 |year= 2002 |pmid= 11815617 |doi= 10.1074/jbc.M111337200
*cite journal | author=Mehta A, Driscoll DM |title=Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing. |journal=RNA |volume=8 |issue= 1 |pages= 69–82 |year= 2002 |pmid= 11871661 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chester A, Somasekaram A, Tzimina M, "et al." |title=The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay. |journal=EMBO J. |volume=22 |issue= 15 |pages= 3971–82 |year= 2003 |pmid= 12881431 |doi= 10.1093/emboj/cdg369
*cite journal | author=Blanc V, Kennedy S, Davidson NO |title=A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling. |journal=J. Biol. Chem. |volume=278 |issue= 42 |pages= 41198–204 |year= 2003 |pmid= 12896982 |doi= 10.1074/jbc.M302951200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Xie K, Sowden MP, Dance GS, "et al." |title=The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 21 |pages= 8114–9 |year= 2004 |pmid= 15148397 |doi= 10.1073/pnas.0400493101
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462

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