SUMO4

SUMO4

SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae), also known as SUMO4, is a human gene.cite web | title = Entrez Gene: SUMO4 SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=387082| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.cite web | title = Entrez Gene: SUMO4 SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=387082| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wang CY, Podolsky R, She JX |title=Genetic and functional evidence supporting SUMO4 as a type 1 diabetes susceptibility gene. |journal=Ann. N. Y. Acad. Sci. |volume=1079 |issue= |pages= 257–67 |year= 2007 |pmid= 17130563 |doi= 10.1196/annals.1375.039
*cite journal | author=Davies JL, Kawaguchi Y, Bennett ST, "et al." |title=A genome-wide search for human type 1 diabetes susceptibility genes. |journal=Nature |volume=371 |issue= 6493 |pages= 130–6 |year= 1994 |pmid= 8072542 |doi= 10.1038/371130a0
*cite journal | author=Luo DF, Buzzetti R, Rotter JI, "et al." |title=Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8. |journal=Hum. Mol. Genet. |volume=5 |issue= 5 |pages= 693–8 |year= 1997 |pmid= 8733139 |doi=
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Bohren KM, Nadkarni V, Song JH, "et al." |title=A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus. |journal=J. Biol. Chem. |volume=279 |issue= 26 |pages= 27233–8 |year= 2004 |pmid= 15123604 |doi= 10.1074/jbc.M402273200
*cite journal | author=Guo D, Li M, Zhang Y, "et al." |title=A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. |journal=Nat. Genet. |volume=36 |issue= 8 |pages= 837–41 |year= 2004 |pmid= 15247916 |doi= 10.1038/ng1391
*cite journal | author=Smyth DJ, Howson JM, Lowe CE, "et al." |title=Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. |journal=Nat. Genet. |volume=37 |issue= 2 |pages= 110–1; author reply 112–3 |year= 2005 |pmid= 15678134 |doi= 10.1038/ng0205-110
*cite journal | author=Qu H, Bharaj B, Liu XQ, "et al." |title=Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. |journal=Nat. Genet. |volume=37 |issue= 2 |pages= 111–2; author reply 112–3 |year= 2005 |pmid= 15678135 |doi= 10.1038/ng0205-111
*cite journal | author=Park Y, Park S, Kang J, "et al." |title=Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. |journal=Nat. Genet. |volume=37 |issue= 2 |pages= 112; author reply 112–3 |year= 2005 |pmid= 15678137 |doi= 10.1038/ng0205-112a
*cite journal | author=Owerbach D, McKay EM, Yeh ET, "et al." |title=A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation. |journal=Biochem. Biophys. Res. Commun. |volume=337 |issue= 2 |pages= 517–20 |year= 2005 |pmid= 16198310 |doi= 10.1016/j.bbrc.2005.09.090
*cite journal | author=Guo D, Han J, Adam BL, "et al." |title=Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. |journal=Biochem. Biophys. Res. Commun. |volume=337 |issue= 4 |pages= 1308–18 |year= 2005 |pmid= 16236267 |doi= 10.1016/j.bbrc.2005.09.191
*cite journal | author=Noso S, Ikegami H, Fujisawa T, "et al." |title=Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes. |journal=Diabetes |volume=54 |issue= 12 |pages= 3582–6 |year= 2006 |pmid= 16306380 |doi=
*cite journal | author=Tsurumaru M, Kawasaki E, Ida H, "et al." |title=Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population. |journal=J. Clin. Endocrinol. Metab. |volume=91 |issue= 8 |pages= 3138–43 |year= 2006 |pmid= 16735488 |doi= 10.1210/jc.2006-0206
*cite journal | author=Costas J, Perez-Pampin E, Ferreiros-Vidal I, "et al." |title=SUMO4 and MAP3K7IP2 single nucleotide polymorphisms and susceptibility to rheumatoid arthritis. |journal=J. Rheumatol. |volume=33 |issue= 6 |pages= 1048–51 |year= 2006 |pmid= 16755651 |doi=
*cite journal | author=Sedimbi SK, Shastry A, Park Y, "et al." |title=Association of SUMO4 M55V polymorphism with autoimmune diabetes in Latvian patients. |journal=Ann. N. Y. Acad. Sci. |volume=1079 |issue= |pages= 273–7 |year= 2007 |pmid= 17130565 |doi= 10.1196/annals.1375.041
*cite journal | author=Lin HY, Wang CL, Hsiao PJ, "et al." |title=SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes. |journal=Diabetes |volume=56 |issue= 4 |pages= 1177–80 |year= 2007 |pmid= 17229939 |doi= 10.2337/db06-1283
*cite journal | author=Sedimbi SK, Kanungo A, Shastry A, "et al." |title=No association of SUMO4 M55V with autoimmune diabetes in Asian-Indian patients. |journal=Int. J. Immunogenet. |volume=34 |issue= 2 |pages= 137–42 |year= 2007 |pmid= 17373940 |doi= 10.1111/j.1744-313X.2007.00668.x
*cite journal | author=Noso S, Fujisawa T, Kawabata Y, "et al." |title=Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population. |journal=J. Clin. Endocrinol. Metab. |volume=92 |issue= 6 |pages= 2358–62 |year= 2007 |pmid= 17374705 |doi= 10.1210/jc.2007-0031
*cite journal | author=Bohren KM, Gabbay KH, Owerbach D |title=Affinity chromatography of native SUMO proteins using His-tagged recombinant UBC9 bound to Co2+-charged talon resin. |journal=Protein Expr. Purif. |volume=54 |issue= 2 |pages= 289–94 |year= 2007 |pmid= 17459725 |doi= 10.1016/j.pep.2007.03.013

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