HLA-B51

Disease Associations

By serotype

Bw51 was associated with Behçet's disease, [cite journal |author=Ohno S, Ohguchi M, Hirose S, Matsuda H, Wakisaka A, Aizawa M |title=Close association of HLA-Bw51 with Behçet's disease |journal=Arch. Ophthalmol. |volume=100 |issue=9 |pages=1455–8 |year=1982 |month=September |pmid=6956266 |doi= |url=] in endemic (versus epidemic) mucocutaneous lymph node syndrome,cite journal |author=Keren G, Danon YL, Orgad S, Kalt R, Gazit E |title=HLA Bw51 is increased in mucocutaneous lymph node syndrome in Israeli patients |journal=Tissue Antigens |volume=20 |issue=2 |pages=144–6 |year=1982 |month=August |pmid=6958087 |doi= |url=] susceptibility to the virus that causes German measles infection.cite journal |author=Ishii K, Nakazono N, Sawada H, "et al" |title=Host factors and susceptibility to rubella virus infection: the association of HLA antigens |journal=J. Med. Virol. |volume=7 |issue=4 |pages=287–97 |year=1981 |pmid=6950026 |doi= |url=]

In Behçet's Disease

Adamanitiades-Behçet's disease (ABD) is an inflammation of the wall of blood vessels that can involve the eyes, skin, and the rest of the body.cite journal |author=Durrani K, Papaliodis GN |title=The genetics of Adamantiades-Behcet's disease |journal=Semin Ophthalmol |volume=23 |issue=1 |pages=73–9 |year=2008 |pmid=18214795 |doi=10.1080/08820530701745264 |url=] Several alleles of B51 (B*5101, B*5108, B*5105, and B*5104) are found in disease, and linkage to markers, D6S285, in the HLA locus was strong (P>0.005).cite journal |author=Karasneh J, Gül A, Ollier WE, Silman AJ, Worthington J |title=Whole-genome screening for susceptibility genes in multicase families with Behçet's disease |journal=Arthritis Rheum. |volume=52 |issue=6 |pages=1836–42 |year=2005 |month=June |pmid=15934084 |doi=10.1002/art.21060 |url=] Homozygotes of B51 showed considerably high risk for disease indicating a possible gene-dose effect. B51 is capable of distinguishing several varieties of disease. HLA-B51 is found more frequently in disease that has an eye involvement.cite journal |author=Krause L, Köhler AK, Altenburg A, "et al" |title=Ocular involvement is associated with HLA-B51 in Adamantiades-Behçet's disease |journal=Eye |volume= |issue= |pages= |year=2008 |month=June |pmid=18551141 |doi=10.1038/eye.2008.177 |url=] However it is less common in some regions when there is increased neurological involvement.cite journal |author=Houman MH, Neffati H, Braham A, "et al" |title=Behçet's disease in Tunisia. Demographic, clinical and genetic aspects in 260 patients |journal=Clin. Exp. Rheumatol. |volume=25 |issue=4 Suppl 45 |pages=S58–64 |year=2007 |pmid=17949553 |doi= |url=http://www.clinexprheumatol.org/pubmed/find-pii.asp?pii=17949553] The MICA*009 allele has been found to also associated with ABD when B51 is also present,cite journal |author=Mizuki N, Meguro A, Tohnai I, Gül A, Ohno S, Mizuki N |title=Association of Major Histocompatibility Complex Class I Chain-Related Gene A and HLA-B Alleles with Behçet's Disease in Turkey |journal=Jpn. J. Ophthalmol. |volume=51 |issue=6 |pages=431–6 |year=2007 |pmid=18158593 |doi=10.1007/s10384-007-0473-y |url=] IL-8 and other cytokines may also be involved.cite journal |author=Lee EB, Kim JY, Zhao J, Park MH, Song YW |title=Haplotype association of IL-8 gene with Behcet's disease |journal=Tissue Antigens |volume=69 |issue=2 |pages=128–32 |year=2007 |month=February |pmid=17257314 |doi=10.1111/j.1399-0039.2006.00736.x |url=] cite journal |author=Pay S, Simşek I, Erdem H, Dinç A |title=Immunopathogenesis of Behçet's disease with special emphasize on the possible role of antigen presenting cells |journal=Rheumatol. Int. |volume=27 |issue=5 |pages=417–24 |year=2007 |month=March |pmid=17171346 |doi=10.1007/s00296-006-0281-6 |url=] Sister chromatid exchange has also been observed more frequently in B51(+) ABD.cite journal |author=Ikbal M, Atasoy M, Pirim I, Aliagaoglu C, Karatay S, Erdem T |title=The alteration of sister chromatid exchange frequencies in Behçet's disease with and without HLA-B51 |journal=J Eur Acad Dermatol Venereol |volume=20 |issue=2 |pages=149–52 |year=2006 |month=February |pmid=16441621 |doi=10.1111/j.1468-3083.2006.01386.x |url=]

However, B51 tends not to be found in ABD when a certain SUMO4 gene variant is involved,cite journal |author=Hou S, Yang P, Du L, "et al" |title=SUMO4 gene polymorphisms in Chinese Han patients with Behcet's disease |journal=Clin. Immunol. |volume= |issue= |pages= |year=2008 |month=July |pmid=18657476 |doi=10.1016/j.clim.2008.06.006 |url=] and symptoms appear to be milder when HLA-B27 is present.cite journal |author=Ahn JK, Park YG |title=Human leukocyte antigen B27 and B51 double-positive Behçet uveitis |journal=Arch. Ophthalmol. |volume=125 |issue=10 |pages=1375–80 |year=2007 |month=October |pmid=17923546 |doi=10.1001/archopht.125.10.1375 |url=]

References