- Phosphoglycerate dehydrogenase
Phosphoglycerate dehydrogenase, also known as PHGDH, is a human
gene .cite web | title = Entrez Gene: PHGDH phosphoglycerate dehydrogenase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26227| accessdate = ]PBB_Summary
section_title =
summary_text = 3-Phosphoglycerate dehydrogenase (PHGDH; EC 1.1.1.95) catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor. [supplied by OMIM] cite web | title = Entrez Gene: PHGDH phosphoglycerate dehydrogenase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26227| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Tsang HT, Connell JW, Brown SE, "et al." |title=A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. |journal=Genomics |volume=88 |issue= 3 |pages= 333–46 |year= 2006 |pmid= 16730941 |doi= 10.1016/j.ygeno.2006.04.003
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Guo D, Han J, Adam BL, "et al." |title=Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. |journal=Biochem. Biophys. Res. Commun. |volume=337 |issue= 4 |pages= 1308–18 |year= 2005 |pmid= 16236267 |doi= 10.1016/j.bbrc.2005.09.191
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Pind S, Slominski E, Mauthe J, "et al." |title=V490M, a common mutation in 3-phosphoglycerate dehydrogenase deficiency, causes enzyme deficiency by decreasing the yield of mature enzyme. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7136–43 |year= 2002 |pmid= 11751922 |doi= 10.1074/jbc.M111419200
*cite journal | author=Klomp LW, de Koning TJ, Malingré HE, "et al." |title=Molecular characterization of 3-phosphoglycerate dehydrogenase deficiency--a neurometabolic disorder associated with reduced L-serine biosynthesis. |journal=Am. J. Hum. Genet. |volume=67 |issue= 6 |pages= 1389–99 |year= 2001 |pmid= 11055895 |doi=
*cite journal | author=Pineda M, Vilaseca MA, Artuch R, "et al." |title=3-phosphoglycerate dehydrogenase deficiency in a patient with West syndrome. |journal=Developmental medicine and child neurology |volume=42 |issue= 9 |pages= 629–33 |year= 2000 |pmid= 11034457 |doi=
*cite journal | author=Baek JY, Jun DY, Taub D, Kim YH |title=Assignment of human 3-phosphoglycerate dehydrogenase (PHGDH) to human chromosome band 1p12 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=89 |issue= 1-2 |pages= 6–7 |year= 2000 |pmid= 10894924 |doi=
*cite journal | author=Cho HM, Jun DY, Bae MA, "et al." |title=Nucleotide sequence and differential expression of the human 3-phosphoglycerate dehydrogenase gene. |journal=Gene |volume=245 |issue= 1 |pages= 193–201 |year= 2000 |pmid= 10713460 |doi=
*cite journal | author=Jaeken J, Detheux M, Van Maldergem L, "et al." |title=3-Phosphoglycerate dehydrogenase deficiency: an inborn error of serine biosynthesis. |journal=Arch. Dis. Child. |volume=74 |issue= 6 |pages= 542–5 |year= 1996 |pmid= 8758134 |doi=PBB_Controls
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