- GMP synthase
Guanine monphosphate synthetase, also known as GMPS is an
enzyme that convertsxanthosine monophosphate toguanosine monophosphate .cite web | title = Entrez Gene: GMPS guanine monphosphate synthetase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8833| accessdate = ]PBB_Summary
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summary_text = In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.cite web | title = Entrez Gene: GMPS guanine monphosphate synthetase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8833| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Page T, Bakay B, Nyhan WL |title=Human GMP synthetase. |journal=Int. J. Biochem. |volume=16 |issue= 1 |pages= 117–20 |year= 1984 |pmid= 6698284 |doi=
*cite journal | author=Nakamura J, Straub K, Wu J, Lou L |title=The glutamine hydrolysis function of human GMP synthetase. Identification of an essential active site cysteine. |journal=J. Biol. Chem. |volume=270 |issue= 40 |pages= 23450–5 |year= 1995 |pmid= 7559506 |doi=
*cite journal | author=Nakamura J, Lou L |title=Biochemical characterization of human GMP synthetase. |journal=J. Biol. Chem. |volume=270 |issue= 13 |pages= 7347–53 |year= 1995 |pmid= 7706277 |doi=
*cite journal | author=Hirst M, Haliday E, Nakamura J, Lou L |title=Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA. |journal=J. Biol. Chem. |volume=269 |issue= 38 |pages= 23830–7 |year= 1994 |pmid= 8089153 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Fedorova L, Kost-Alimova M, Gizatullin RZ, "et al." |title=Assignment and ordering of twenty-three unique NotI-linking clones containing expressed genes including the guanosine 5'-monophosphate synthetase gene to human chromosome 3. |journal=Eur. J. Hum. Genet. |volume=5 |issue= 2 |pages= 110–6 |year= 1997 |pmid= 9195163 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Pegram LD, Megonigal MD, Lange BJ, "et al." |title=t(3;11) translocation in treatment-related acute myeloid leukemia fuses MLL with the GMPS (GUANOSINE 5' MONOPHOSPHATE SYNTHETASE) gene. |journal=Blood |volume=96 |issue= 13 |pages= 4360–2 |year= 2001 |pmid= 11110714 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Guo D, Han J, Adam BL, "et al." |title=Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. |journal=Biochem. Biophys. Res. Commun. |volume=337 |issue= 4 |pages= 1308–18 |year= 2005 |pmid= 16236267 |doi= 10.1016/j.bbrc.2005.09.191External links
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