GMP synthase (glutamine-hydrolysing)

In enzymology, a GMP synthase (glutamine-hydrolysing) (EC number|6.3.5.2) is an enzyme that catalyzes the chemical reaction

:ATP + xanthosine 5'-phosphate + L-glutamine + H₂O $ightleftharpoons$ AMP + diphosphate + GMP + L-glutamate

The 4 substrates of this enzyme are ATP, xanthosine 5'-phosphate, L-glutamine, and H₂O, whereas its 4 products are AMP, diphosphate, GMP, and L-glutamate.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds carbon-nitrogen ligases with glutamine as amido-N-donor. The systematic name of this enzyme class is xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming). Other names in common use include GMP synthetase (glutamine-hydrolysing), guanylate synthetase (glutamine-hydrolyzing), guanosine monophosphate synthetase (glutamine-hydrolyzing), xanthosine 5'-phosphate amidotransferase, and guanosine 5'-monophosphate synthetase. This enzyme participates in purine metabolism and glutamate metabolism. At least one compound, Psicofuranin is known to inhibit this enzyme.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1GPM, PDB link|1WL8, PDB link|2A9V, PDB link|2D7J, and PDB link|2DPL.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37318-71-1."

Gene Ontology (GO) codes