STK4

STK4

Serine/threonine kinase 4, also known as STK4, is a human gene.

PBB_Summary
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summary_text = The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.cite web | title = Entrez Gene: STK4 serine/threonine kinase 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6789| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=de Souza PM, Lindsay MA |title=Mammalian Sterile20-like kinase 1 and the regulation of apoptosis. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt3 |pages= 485–8 |year= 2005 |pmid= 15157167 |doi= 10.1042/BST0320485
*cite journal | author=Han S, Stuart LA, Degen SJ |title=Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor. |journal=Biochemistry |volume=30 |issue= 40 |pages= 9768–80 |year= 1991 |pmid= 1655021 |doi=
*cite journal | author=Gerber MJ, Drabkin HA, Firnhaber C, "et al." |title=Regional localization of chromosome 3-specific DNA fragments by using a hybrid cell deletion mapping panel. |journal=Am. J. Hum. Genet. |volume=43 |issue= 4 |pages= 442–51 |year= 1988 |pmid= 2902784 |doi=
*cite journal | author=Creasy CL, Chernoff J |title=Cloning and characterization of a human protein kinase with homology to Ste20. |journal=J. Biol. Chem. |volume=270 |issue= 37 |pages= 21695–700 |year= 1995 |pmid= 7665586 |doi=
*cite journal | author=Schultz SJ, Nigg EA |title=Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. |journal=Cell Growth Differ. |volume=4 |issue= 10 |pages= 821–30 |year= 1994 |pmid= 8274451 |doi=
*cite journal | author=Creasy CL, Chernoff J |title=Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. |journal=Gene |volume=167 |issue= 1-2 |pages= 303–6 |year= 1996 |pmid= 8566796 |doi=
*cite journal | author=Creasy CL, Ambrose DM, Chernoff J |title=The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain. |journal=J. Biol. Chem. |volume=271 |issue= 35 |pages= 21049–53 |year= 1996 |pmid= 8702870 |doi=
*cite journal | author=Taylor LK, Wang HC, Erikson RL |title=Newly identified stress-responsive protein kinases, Krs-1 and Krs-2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 19 |pages= 10099–104 |year= 1996 |pmid= 8816758 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Graves JD, Gotoh Y, Draves KE, "et al." |title=Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. |journal=EMBO J. |volume=17 |issue= 8 |pages= 2224–34 |year= 1998 |pmid= 9545236 |doi= 10.1093/emboj/17.8.2224
*cite journal | author=Lee KK, Ohyama T, Yajima N, "et al." |title=MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19276–85 |year= 2001 |pmid= 11278283 |doi= 10.1074/jbc.M005109200
*cite journal | author=Graves JD, Draves KE, Gotoh Y, "et al." |title=Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 14909–15 |year= 2001 |pmid= 11278782 |doi= 10.1074/jbc.M010905200
*cite journal | author=Ura S, Masuyama N, Graves JD, Gotoh Y |title=Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 18 |pages= 10148–53 |year= 2001 |pmid= 11517310 |doi= 10.1073/pnas.181161698
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Lee KK, Yonehara S |title=Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST). |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 12351–8 |year= 2002 |pmid= 11805089 |doi= 10.1074/jbc.M108138200
*cite journal | author=Khokhlatchev A, Rabizadeh S, Xavier R, "et al." |title=Identification of a novel Ras-regulated proapoptotic pathway. |journal=Curr. Biol. |volume=12 |issue= 4 |pages= 253–65 |year= 2002 |pmid= 11864565 |doi=
*cite journal | author=De Souza PM, Kankaanranta H, Michael A, "et al." |title=Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis. |journal=Blood |volume=99 |issue= 9 |pages= 3432–8 |year= 2002 |pmid= 11964314 |doi=
*cite journal | author=Glantschnig H, Rodan GA, Reszka AA |title=Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42987–96 |year= 2003 |pmid= 12223493 |doi= 10.1074/jbc.M208538200
*cite journal | author=Lin Y, Khokhlatchev A, Figeys D, Avruch J |title=Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. |journal=J. Biol. Chem. |volume=277 |issue= 50 |pages= 47991–8001 |year= 2003 |pmid= 12384512 |doi= 10.1074/jbc.M202630200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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