- PRKCB1
Protein kinase C, beta 1, also known as PRKCB1, is a human
gene .PBB_Summary
section_title =
summary_text = Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported [cite web | title = Entrez Gene: PRKCB1 protein kinase C, beta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5579| accessdate = ] . This gene could be associated withautism [Citation
pmid =:16027742
url=http://www.ncbi.nlm.nih.gov/pubmed/16027742
last=Philippi
first=A
last2=Roschmann
first2=E
last3=Tores
first3=F
last4=Lindenbaum
first4=P
publication-date=2005 Oct
year=2005
title=Haplotypes in the gene encoding protein kinase c-beta (PRKCB1) on chromosome 16 are associated with autism.
volume=10
issue=10
periodical=Mol. Psychiatry
pages=950-604001704
doi = 10.1038/sj.mp.400170416027742] .References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Mochly-Rosen D |title=Localization of protein kinases by anchoring proteins: a theme in signal transduction. |journal=Science |volume=268 |issue= 5208 |pages= 247–51 |year= 1995 |pmid= 7716516 |doi=
*cite journal | author=Ali A, Hoeflich KP, Woodgett JR |title=Glycogen synthase kinase-3: properties, functions, and regulation. |journal=Chem. Rev. |volume=101 |issue= 8 |pages= 2527–40 |year= 2002 |pmid= 11749387 |doi=
*cite journal | author=Slater SJ, Ho C, Stubbs CD |title=The use of fluorescent phorbol esters in studies of protein kinase C-membrane interactions. |journal=Chem. Phys. Lipids |volume=116 |issue= 1-2 |pages= 75–91 |year= 2003 |pmid= 12093536 |doi=ee also
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Protein kinase C PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes
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