- MAP3K3
Mitogen-activated protein kinase kinase kinase 3, also known as MAP3K3, is a human
gene .PBB_Summary
section_title =
summary_text = This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.cite web | title = Entrez Gene: MAP3K3 mitogen-activated protein kinase kinase kinase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4215| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U |title=Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative. |journal=J. Biol. Chem. |volume=272 |issue= 5 |pages= 2668–74 |year= 1997 |pmid= 9006902 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Fanger GR, Widmann C, Porter AC, "et al." |title=14-3-3 proteins interact with specific MEK kinases. |journal=J. Biol. Chem. |volume=273 |issue= 6 |pages= 3476–83 |year= 1998 |pmid= 9452471 |doi=
*cite journal | author=Chao TH, Hayashi M, Tapping RI, "et al." |title=MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway. |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36035–8 |year= 2000 |pmid= 10593883 |doi=
*cite journal | author=Yang J, Boerm M, McCarty M, "et al." |title=Mekk3 is essential for early embryonic cardiovascular development. |journal=Nat. Genet. |volume=24 |issue= 3 |pages= 309–13 |year= 2000 |pmid= 10700190 |doi= 10.1038/73550
*cite journal | author=Sun W, Kesavan K, Schaefer BC, "et al." |title=MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 5093–100 |year= 2001 |pmid= 11073940 |doi= 10.1074/jbc.M003719200
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Yang J, Lin Y, Guo Z, "et al." |title=The essential role of MEKK3 in TNF-induced NF-kappaB activation. |journal=Nat. Immunol. |volume=2 |issue= 7 |pages= 620–4 |year= 2001 |pmid= 11429546 |doi= 10.1038/89769
*cite journal | author=Che W, Lerner-Marmarosh N, Huang Q, "et al." |title=Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression. |journal=Circ. Res. |volume=90 |issue= 11 |pages= 1222–30 |year= 2002 |pmid= 12065326 |doi=
*cite journal | author=Lee CM, Onésime D, Reddy CD, "et al." |title=JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 22 |pages= 14189–94 |year= 2002 |pmid= 12391307 |doi= 10.1073/pnas.232310199
*cite journal | author=Adams DG, Sachs NA, Vaillancourt RR |title=Phosphorylation of the stress-activated protein kinase, MEKK3, at serine 166. |journal=Arch. Biochem. Biophys. |volume=407 |issue= 1 |pages= 103–16 |year= 2002 |pmid= 12392720 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Matsuda A, Suzuki Y, Honda G, "et al." |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. |journal=Oncogene |volume=22 |issue= 21 |pages= 3307–18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406
*cite journal | author=Nakamura K, Johnson GL |title=PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway. |journal=J. Biol. Chem. |volume=278 |issue= 39 |pages= 36989–92 |year= 2003 |pmid= 12912994 |doi= 10.1074/jbc.C300313200
*cite journal | author=Huang Q, Yang J, Lin Y, "et al." |title=Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3. |journal=Nat. Immunol. |volume=5 |issue= 1 |pages= 98–103 |year= 2004 |pmid= 14661019 |doi= 10.1038/ni1014
*cite journal | author=Samanta AK, Huang HJ, Bast RC, Liao WS |title=Overexpression of MEKK3 confers resistance to apoptosis through activation of NFkappaB. |journal=J. Biol. Chem. |volume=279 |issue= 9 |pages= 7576–83 |year= 2004 |pmid= 14662759 |doi= 10.1074/jbc.M311659200PBB_Controls
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