LMO2

LIM domain only 2 (rhombotin-like 1), also known as LMO2, is a human gene.

PBB_Summary
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summary_text = LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur.cite web | title = Entrez Gene: LMO2 LIM domain only 2 (rhombotin-like 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4005| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Royer-Pokora B, Loos U, Ludwig WD |title=TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). |journal=Oncogene |volume=6 |issue= 10 |pages= 1887–93 |year= 1991 |pmid= 1923511 |doi=
*cite journal | author=Boehm T, Foroni L, Kaneko Y, "et al." |title=The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 10 |pages= 4367–71 |year= 1991 |pmid= 2034676 |doi=
*cite journal | author=Boehm T, Spillantini MG, Sofroniew MV, "et al." |title=Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression. |journal=Oncogene |volume=6 |issue= 5 |pages= 695–703 |year= 1991 |pmid= 2052354 |doi=
*cite journal | author=Dong WF, Xu Y, Hu QL, "et al." |title=Molecular characterization of a chromosome translocation breakpoint t(11;14)(p13;q11) from the cell line KOPT-K1. |journal=Leukemia |volume=9 |issue= 11 |pages= 1812–7 |year= 1995 |pmid= 7475267 |doi=
*cite journal | author=Osada H, Grutz G, Axelson H, "et al." |title=Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 21 |pages= 9585–9 |year= 1995 |pmid= 7568177 |doi=
*cite journal | author=Sánchez-García I, Axelson H, Rabbitts TH |title=Functional diversity of LIM proteins: amino-terminal activation domains in the oncogenic proteins RBTN1 and RBTN2. |journal=Oncogene |volume=10 |issue= 7 |pages= 1301–6 |year= 1995 |pmid= 7731680 |doi=
*cite journal | author=Wadman I, Li J, Bash RO, "et al." |title=Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. |journal=EMBO J. |volume=13 |issue= 20 |pages= 4831–9 |year= 1994 |pmid= 7957052 |doi=
*cite journal | author=Valge-Archer VE, Osada H, Warren AJ, "et al." |title=The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 18 |pages= 8617–21 |year= 1994 |pmid= 8078932 |doi=
*cite journal | author=Wilkinson DA, Neale GA, Mao S, "et al." |title=Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia. |journal=Leukemia |volume=11 |issue= 1 |pages= 86–96 |year= 1997 |pmid= 9001422 |doi=
*cite journal | author=Mao S, Neale GA, Goorha RM |title=T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2. |journal=Oncogene |volume=14 |issue= 13 |pages= 1531–9 |year= 1997 |pmid= 9129143 |doi= 10.1038/sj.onc.1200988
*cite journal | author=Osada H, Grutz GG, Axelson H, "et al." |title=LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1. |journal=Leukemia |volume=11 Suppl 3 |issue= |pages= 307–12 |year= 1997 |pmid= 9209374 |doi=
*cite journal | author=Wadman IA, Osada H, Grütz GG, "et al." |title=The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. |journal=EMBO J. |volume=16 |issue= 11 |pages= 3145–57 |year= 1997 |pmid= 9214632 |doi= 10.1093/emboj/16.11.3145
*cite journal | author=Visvader JE, Mao X, Fujiwara Y, "et al." |title=The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 25 |pages= 13707–12 |year= 1998 |pmid= 9391090 |doi=
*cite journal | author=Jurata LW, Pfaff SL, Gill GN |title=The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors. |journal=J. Biol. Chem. |volume=273 |issue= 6 |pages= 3152–7 |year= 1998 |pmid= 9452425 |doi=
*cite journal | author=Kenny DA, Jurata LW, Saga Y, Gill GN |title=Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11257–62 |year= 1998 |pmid= 9736723 |doi=
*cite journal | author=Ono Y, Fukuhara N, Yoshie O |title=TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. |journal=Mol. Cell. Biol. |volume=18 |issue= 12 |pages= 6939–50 |year= 1998 |pmid= 9819382 |doi=
*cite journal | author=Bach I, Rodriguez-Esteban C, Carrière C, "et al." |title=RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. |journal=Nat. Genet. |volume=22 |issue= 4 |pages= 394–9 |year= 1999 |pmid= 10431247 |doi= 10.1038/11970
*cite journal | author=Vitelli L, Condorelli G, Lulli V, "et al." |title=A pentamer transcriptional complex including tal-1 and retinoblastoma protein downmodulates c-kit expression in normal erythroblasts. |journal=Mol. Cell. Biol. |volume=20 |issue= 14 |pages= 5330–42 |year= 2000 |pmid= 10866689 |doi=
*cite journal | author=Davenport J, Neale GA, Goorha R |title=Identification of genes potentially involved in LMO2-induced leukemogenesis. |journal=Leukemia |volume=14 |issue= 11 |pages= 1986–96 |year= 2000 |pmid= 11069036 |doi=
*cite journal | author=Sum EY, Peng B, Yu X, "et al." |title=The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 7849–56 |year= 2002 |pmid= 11751867 |doi= 10.1074/jbc.M110603200

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