- GRK4
G protein-coupled receptor kinase 4, also known as GRK4, is a human
gene .cite web | title = Entrez Gene: GRK4 G protein-coupled receptor kinase 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2868| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension.cite web | title = Entrez Gene: GRK4 G protein-coupled receptor kinase 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2868| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Ambrose C, James M, Barnes G, "et al." |title=A novel G protein-coupled receptor kinase gene cloned from 4p16.3. |journal=Hum. Mol. Genet. |volume=1 |issue= 9 |pages= 697–703 |year= 1993 |pmid= 1338872 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Sallese M, Lombardi MS, De Blasi A |title=Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning. |journal=Biochem. Biophys. Res. Commun. |volume=199 |issue= 2 |pages= 848–54 |year= 1994 |pmid= 8135832 |doi=
*cite journal | author=Premont RT, Macrae AD, Stoffel RH, "et al." |title=Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. |journal=J. Biol. Chem. |volume=271 |issue= 11 |pages= 6403–10 |year= 1996 |pmid= 8626439 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Sallese M, Mariggiò S, Collodel G, "et al." |title=G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells. |journal=J. Biol. Chem. |volume=272 |issue= 15 |pages= 10188–95 |year= 1997 |pmid= 9092566 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Lazari MF, Liu X, Nakamura K, "et al." |title=Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor. |journal=Mol. Endocrinol. |volume=13 |issue= 6 |pages= 866–78 |year= 1999 |pmid= 10379886 |doi=
*cite journal | author=Blaukat A, Pizard A, Breit A, "et al." |title=Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 40431–40 |year= 2001 |pmid= 11517230 |doi= 10.1074/jbc.M107024200
*cite journal | author=Watanabe H, Xu J, Bengra C, "et al." |title=Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4. |journal=Kidney Int. |volume=62 |issue= 3 |pages= 790–8 |year= 2003 |pmid= 12164861 |doi= 10.1046/j.1523-1755.2002.00525.x
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Perroy J, Adam L, Qanbar R, "et al." |title=Phosphorylation-independent desensitization of GABA(B) receptor by GRK4. |journal=EMBO J. |volume=22 |issue= 15 |pages= 3816–24 |year= 2003 |pmid= 12881416 |doi= 10.1093/emboj/cdg383
*cite journal | author=Speirs HJ, Katyk K, Kumar NN, "et al." |title=Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension. |journal=J. Hypertens. |volume=22 |issue= 5 |pages= 931–6 |year= 2004 |pmid= 15097232 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hillier LW, Graves TA, Fulton RS, "et al." |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466
*cite journal | author=Rankin ML, Marinec PS, Cabrera DM, "et al." |title=The D1 dopamine receptor is constitutively phosphorylated by G protein-coupled receptor kinase 4. |journal=Mol. Pharmacol. |volume=69 |issue= 3 |pages= 759–69 |year= 2006 |pmid= 16338988 |doi= 10.1124/mol.105.019901
*cite journal | author=Zhu H, Lu Y, Wang X, "et al." |title=The G protein-coupled receptor kinase 4 gene affects blood pressure in young normotensive twins. |journal=Am. J. Hypertens. |volume=19 |issue= 1 |pages= 61–6 |year= 2006 |pmid= 16461192 |doi= 10.1016/j.amjhyper.2005.07.007
*cite journal | author=Zhu H, Lu Y, Wang X, "et al." |title=The G protein-coupled receptor kinase 4 gene modulates stress-induced sodium excretion in black normotensive adolescents. |journal=Pediatr. Res. |volume=60 |issue= 4 |pages= 440–2 |year= 2006 |pmid= 16940246 |doi= 10.1203/01.pdr.0000238250.64591.44
*cite journal | author=Wang Y, Li B, Zhao W, "et al." |title=Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese. |journal=Ann. Hum. Genet. |volume=70 |issue= Pt 6 |pages= 778–83 |year= 2006 |pmid= 17044852 |doi= 10.1111/j.1469-1809.2006.00278.x
*cite journal | author=Wang Z, Armando I, Asico LD, "et al." |title=The elevated blood pressure of human GRK4gamma A142V transgenic mice is not associated with increased ROS production. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=292 |issue= 5 |pages= H2083–92 |year= 2007 |pmid= 17259440 |doi= 10.1152/ajpheart.00944.2006PBB_Controls
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