STK11

Serine/threonine kinase 11, also known as STK11, is a human gene.

PBB_Summary
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summary_text = This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [cite web | title = Entrez Gene: STK11 serine/threonine kinase 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6794| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yoo LI, Chung DC, Yuan J |title=LKB1--a master tumour suppressor of the small intestine and beyond. |journal=Nat. Rev. Cancer |volume=2 |issue= 7 |pages= 529–35 |year= 2002 |pmid= 12094239 |doi= 10.1038/nrc843
*cite journal | author=Baas AF, Smit L, Clevers H |title=LKB1 tumor suppressor protein: PARtaker in cell polarity. |journal=Trends Cell Biol. |volume=14 |issue= 6 |pages= 312–9 |year= 2004 |pmid= 15183188 |doi= 10.1016/j.tcb.2004.04.001
*cite journal | author=Katajisto P, Vallenius T, Vaahtomeri K, "et al." |title=The LKB1 tumor suppressor kinase in human disease. |journal=Biochim. Biophys. Acta |volume=1775 |issue= 1 |pages= 63–75 |year= 2007 |pmid= 17010524 |doi= 10.1016/j.bbcan.2006.08.003
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Hemminki A, Tomlinson I, Markie D, "et al." |title=Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. |journal=Nat. Genet. |volume=15 |issue= 1 |pages= 87–90 |year= 1997 |pmid= 8988175 |doi= 10.1038/ng0197-87
*cite journal | author=Jenne DE, Reimann H, Nezu J, "et al." |title=Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. |journal=Nat. Genet. |volume=18 |issue= 1 |pages= 38–43 |year= 1998 |pmid= 9425897 |doi= 10.1038/ng0198-38
*cite journal | author=Hemminki A, Markie D, Tomlinson I, "et al." |title=A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. |journal=Nature |volume=391 |issue= 6663 |pages= 184–7 |year= 1998 |pmid= 9428765 |doi= 10.1038/34432
*cite journal | author=Bignell GR, Barfoot R, Seal S, "et al." |title=Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer. |journal=Cancer Res. |volume=58 |issue= 7 |pages= 1384–6 |year= 1998 |pmid= 9537235 |doi=
*cite journal | author=Nakagawa H, Koyama K, Miyoshi Y, "et al." |title=Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome. |journal=Hum. Genet. |volume=103 |issue= 2 |pages= 168–72 |year= 1998 |pmid= 9760200 |doi=
*cite journal | author=Mehenni H, Gehrig C, Nezu J, "et al." |title=Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity. |journal=Am. J. Hum. Genet. |volume=63 |issue= 6 |pages= 1641–50 |year= 1999 |pmid= 9837816 |doi=
*cite journal | author=Guldberg P, thor Straten P, Ahrenkiel V, "et al." |title=Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma. |journal=Oncogene |volume=18 |issue= 9 |pages= 1777–80 |year= 1999 |pmid= 10208439 |doi= 10.1038/sj.onc.1202486
*cite journal | author=Su GH, Hruban RH, Bansal RK, "et al." |title=Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. |journal=Am. J. Pathol. |volume=154 |issue= 6 |pages= 1835–40 |year= 1999 |pmid= 10362809 |doi=
*cite journal | author=Westerman AM, Entius MM, Boor PP, "et al." |title=Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families. |journal=Hum. Mutat. |volume=13 |issue= 6 |pages= 476–81 |year= 1999 |pmid= 10408777 |doi= 10.1002/(SICI)1098-1004(1999)13:6<476::AID-HUMU7>3.0.CO;2-2 |doilabel=10.1002/(SICI)1098-1004(1999)13:6476::AID-HUMU73.0.CO;2-2
*cite journal | author=Scanlan MJ, Gordan JD, Williamson B, "et al." |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456–64 |year= 1999 |pmid= 10508479 |doi=
*cite journal | author=Collins SP, Reoma JL, Gamm DM, Uhler MD |title=LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. |journal=Biochem. J. |volume=345 Pt 3 |issue= |pages= 673–80 |year= 2000 |pmid= 10642527 |doi=
*cite journal | author=Sapkota GP, Kieloch A, Lizcano JM, "et al." |title=Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19469–82 |year= 2001 |pmid= 11297520 |doi= 10.1074/jbc.M009953200
*cite journal | author=Karuman P, Gozani O, Odze RD, "et al." |title=The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. |journal=Mol. Cell |volume=7 |issue= 6 |pages= 1307–19 |year= 2001 |pmid= 11430832 |doi=
*cite journal | author=Marignani PA, Kanai F, Carpenter CL |title=LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 32415–8 |year= 2001 |pmid= 11445556 |doi= 10.1074/jbc.C100207200
*cite journal | author=Abed AA, Günther K, Kraus C, "et al." |title=Mutation screening at the RNA level of the STK11/LKB1 gene in Peutz-Jeghers syndrome reveals complex splicing abnormalities and a novel mRNA isoform (STK11 c.597(insertion mark)598insIVS4). |journal=Hum. Mutat. |volume=18 |issue= 5 |pages= 397–410 |year= 2002 |pmid= 11668633 |doi= 10.1002/humu.1211
*cite journal | author=Sato N, Rosty C, Jansen M, "et al." |title=STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas. |journal=Am. J. Pathol. |volume=159 |issue= 6 |pages= 2017–22 |year= 2001 |pmid= 11733352 |doi=

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