PLK4

PLK4

Polo-like kinase 4 (Drosophila), also known as PLK4, is a human gene.cite web | title = Entrez Gene: PLK4 polo-like kinase 4 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10733| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle.cite web | title = Entrez Gene: PLK4 polo-like kinase 4 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10733| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kleylein-Sohn J, Westendorf J, Le Clech M, "et al." |title=Plk4-induced centriole biogenesis in human cells. |journal=Dev. Cell |volume=13 |issue= 2 |pages= 190–202 |year= 2007 |pmid= 17681131 |doi= 10.1016/j.devcel.2007.07.002
*cite journal | author=Bettencourt-Dias M, Rodrigues-Martins A, Carpenter L, "et al." |title=SAK/PLK4 is required for centriole duplication and flagella development. |journal=Curr. Biol. |volume=15 |issue= 24 |pages= 2199–207 |year= 2006 |pmid= 16326102 |doi= 10.1016/j.cub.2005.11.042
*cite journal | author=Habedanck R, Stierhof YD, Wilkinson CJ, Nigg EA |title=The Polo kinase Plk4 functions in centriole duplication. |journal=Nat. Cell Biol. |volume=7 |issue= 11 |pages= 1140–6 |year= 2006 |pmid= 16244668 |doi= 10.1038/ncb1320
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Li J, Tan M, Li L, "et al." |title=SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing. |journal=Neoplasia |volume=7 |issue= 4 |pages= 312–23 |year= 2005 |pmid= 15967108 |doi=
*cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, "et al." |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Suzuki Y, Yamashita R, Shirota M, "et al." |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Macmillan JC, Hudson JW, Bull S, "et al." |title=Comparative expression of the mitotic regulators SAK and PLK in colorectal cancer. |journal=Ann. Surg. Oncol. |volume=8 |issue= 9 |pages= 729–40 |year= 2002 |pmid= 11597015 |doi=
*cite journal | author=Yamashita Y, Kajigaya S, Yoshida K, "et al." |title=Sak serine-threonine kinase acts as an effector of Tec tyrosine kinase. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39012–20 |year= 2001 |pmid= 11489907 |doi= 10.1074/jbc.M106249200
*cite journal | author=Hudson JW, Chen L, Fode C, "et al." |title=Sak kinase gene structure and transcriptional regulation. |journal=Gene |volume=241 |issue= 1 |pages= 65–73 |year= 2000 |pmid= 10607900 |doi=
*cite journal | author=Schultz SJ, Nigg EA |title=Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. |journal=Cell Growth Differ. |volume=4 |issue= 10 |pages= 821–30 |year= 1994 |pmid= 8274451 |doi=

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