MAP3K8

Mitogen-activated protein kinase kinase kinase 8, also known as MAP3K8, is a human gene.cite web | title = Entrez Gene: MAP3K8 mitogen-activated protein kinase kinase kinase 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1326| accessdate = ]

PBB_Summary
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summary_text = This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.cite web | title = Entrez Gene: MAP3K8 mitogen-activated protein kinase kinase kinase 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1326| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Aoki M, Akiyama T, Miyoshi J, Toyoshima K |title=Identification and characterization of protein products of the cot oncogene with serine kinase activity. |journal=Oncogene |volume=6 |issue= 9 |pages= 1515–9 |year= 1991 |pmid= 1833717 |doi=
*cite journal | author=Miyoshi J, Higashi T, Mukai H, "et al." |title=Structure and transforming potential of the human cot oncogene encoding a putative protein kinase. |journal=Mol. Cell. Biol. |volume=11 |issue= 8 |pages= 4088–96 |year= 1991 |pmid= 2072910 |doi=
*cite journal | author=Aoki M, Hamada F, Sugimoto T, "et al." |title=The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation. |journal=J. Biol. Chem. |volume=268 |issue= 30 |pages= 22723–32 |year= 1993 |pmid= 8226782 |doi=
*cite journal | author=Chan AM, Chedid M, McGovern ES, "et al." |title=Expression cDNA cloning of a serine kinase transforming gene. |journal=Oncogene |volume=8 |issue= 5 |pages= 1329–33 |year= 1993 |pmid= 8479752 |doi=
*cite journal | author=Salmeron A, Ahmad TB, Carlile GW, "et al." |title=Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase. |journal=EMBO J. |volume=15 |issue= 4 |pages= 817–26 |year= 1996 |pmid= 8631303 |doi=
*cite journal | author=Ballester A, Tobeña R, Lisbona C, "et al." |title=Cot kinase regulation of IL-2 production in Jurkat T cells. |journal=J. Immunol. |volume=159 |issue= 4 |pages= 1613–8 |year= 1997 |pmid= 9257820 |doi=
*cite journal | author=Ballester A, Velasco A, Tobeña R, Alemany S |title=Cot kinase activates tumor necrosis factor-alpha gene expression in a cyclosporin A-resistant manner. |journal=J. Biol. Chem. |volume=273 |issue= 23 |pages= 14099–106 |year= 1998 |pmid= 9603908 |doi=
*cite journal | author=Lin X, Mu Y, Cunningham ET, "et al." |title=Molecular determinants of NF-kappaB-inducing kinase action. |journal=Mol. Cell. Biol. |volume=18 |issue= 10 |pages= 5899–907 |year= 1998 |pmid= 9742107 |doi=
*cite journal | author=Belich MP, Salmerón A, Johnston LH, Ley SC |title=TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105. |journal=Nature |volume=397 |issue= 6717 |pages= 363–8 |year= 1999 |pmid= 9950430 |doi= 10.1038/16946
*cite journal | author=Lin X, Cunningham ET, Mu Y, "et al." |title=The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases. |journal=Immunity |volume=10 |issue= 2 |pages= 271–80 |year= 1999 |pmid= 10072079 |doi=
*cite journal | author=Chiariello M, Marinissen MJ, Gutkind JS |title=Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1747–58 |year= 2000 |pmid= 10669751 |doi=
*cite journal | author=Sánchez-Góngora E, Lisbona C, de Gregorio R, "et al." |title=COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation. |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 31379–86 |year= 2000 |pmid= 10896655 |doi= 10.1074/jbc.M000382200
*cite journal | author=Luftig MA, Cahir-McFarland E, Mosialos G, Kieff E |title=Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 14602–6 |year= 2001 |pmid= 11278268 |doi= 10.1074/jbc.C100103200
*cite journal | author=Eliopoulos AG, Davies C, Blake SS, "et al." |title=The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2. |journal=J. Virol. |volume=76 |issue= 9 |pages= 4567–79 |year= 2002 |pmid= 11932422 |doi=
*cite journal | author=Kane LP, Mollenauer MN, Xu Z, "et al." |title=Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription. |journal=Mol. Cell. Biol. |volume=22 |issue= 16 |pages= 5962–74 |year= 2002 |pmid= 12138205 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Waterfield MR, Zhang M, Norman LP, Sun SC |title=NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase. |journal=Mol. Cell |volume=11 |issue= 3 |pages= 685–94 |year= 2003 |pmid= 12667451 |doi=
*cite journal | author=Channavajhala PL, Wu L, Cuozzo JW, "et al." |title=Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling. |journal=J. Biol. Chem. |volume=278 |issue= 47 |pages= 47089–97 |year= 2004 |pmid= 12975377 |doi= 10.1074/jbc.M306002200
*cite journal | author=Gándara ML, López P, Hernando R, "et al." |title=The COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activity. |journal=Mol. Cell. Biol. |volume=23 |issue= 20 |pages= 7377–90 |year= 2003 |pmid= 14517305 |doi=
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086

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