MAP3K1

Mitogen-activated protein kinase kinase kinase 1, also known as MAP3K1, is a human gene.cite web | title = Entrez Gene: MAP3K1 mitogen-activated protein kinase kinase kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4214| accessdate = ]

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summary_text = MAP3K, or MEK kinase, is a serine/threonine kinase that occupies a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including insulin (MIM 176730) and many growth factors. [supplied by OMIM] cite web | title = Entrez Gene: MAP3K1 mitogen-activated protein kinase kinase kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4214| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Vinik BS, Kay ES, Fiedorek FT |title=Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5. |journal=Mamm. Genome |volume=6 |issue= 11 |pages= 782–3 |year= 1996 |pmid= 8597633 |doi=
*cite journal | author=Lee FS, Hagler J, Chen ZJ, Maniatis T |title=Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway. |journal=Cell |volume=88 |issue= 2 |pages= 213–22 |year= 1997 |pmid= 9008162 |doi=
*cite journal | author=Siow YL, Kalmar GB, Sanghera JS, "et al." |title=Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1. Indirect activation by Pak3 and protein kinase C. |journal=J. Biol. Chem. |volume=272 |issue= 12 |pages= 7586–94 |year= 1997 |pmid= 9065412 |doi=
*cite journal | author=Su YC, Han J, Xu S, "et al." |title=NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. |journal=EMBO J. |volume=16 |issue= 6 |pages= 1279–90 |year= 1997 |pmid= 9135144 |doi= 10.1093/emboj/16.6.1279
*cite journal | author=Wu Z, Wu J, Jacinto E, Karin M |title=Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase. |journal=Mol. Cell. Biol. |volume=17 |issue= 12 |pages= 7407–16 |year= 1997 |pmid= 9372971 |doi=
*cite journal | author=Xu S, Cobb MH |title=MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32056–60 |year= 1998 |pmid= 9405400 |doi=
*cite journal | author=Fanger GR, Widmann C, Porter AC, "et al." |title=14-3-3 proteins interact with specific MEK kinases. |journal=J. Biol. Chem. |volume=273 |issue= 6 |pages= 3476–83 |year= 1998 |pmid= 9452471 |doi=
*cite journal | author=Hirai S, Noda K, Moriguchi T, "et al." |title=Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2. |journal=J. Biol. Chem. |volume=273 |issue= 13 |pages= 7406–12 |year= 1998 |pmid= 9516438 |doi=
*cite journal | author=Saltzman A, Searfoss G, Marcireau C, "et al." |title=hUBC9 associates with MEKK1 and type I TNF-alpha receptor and stimulates NFkappaB activity. |journal=FEBS Lett. |volume=425 |issue= 3 |pages= 431–5 |year= 1998 |pmid= 9563508 |doi=
*cite journal | author=Guan Z, Buckman SY, Pentland AP, "et al." |title=Induction of cyclooxygenase-2 by the activated MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathway. |journal=J. Biol. Chem. |volume=273 |issue= 21 |pages= 12901–8 |year= 1998 |pmid= 9582321 |doi=
*cite journal | author=Lee FS, Peters RT, Dang LC, Maniatis T |title=MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 16 |pages= 9319–24 |year= 1998 |pmid= 9689078 |doi=
*cite journal | author=Yuasa T, Ohno S, Kehrl JH, Kyriakis JM |title=Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38. |journal=J. Biol. Chem. |volume=273 |issue= 35 |pages= 22681–92 |year= 1998 |pmid= 9712898 |doi=
*cite journal | author=Pomérance M, Multon MC, Parker F, "et al." |title=Grb2 interaction with MEK-kinase 1 is involved in regulation of Jun-kinase activities in response to epidermal growth factor. |journal=J. Biol. Chem. |volume=273 |issue= 38 |pages= 24301–4 |year= 1998 |pmid= 9733714 |doi=
*cite journal | author=Xia Y, Wu Z, Su B, "et al." |title=JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. |journal=Genes Dev. |volume=12 |issue= 21 |pages= 3369–81 |year= 1998 |pmid= 9808624 |doi=
*cite journal | author=Nemoto S, DiDonato JA, Lin A |title=Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase. |journal=Mol. Cell. Biol. |volume=18 |issue= 12 |pages= 7336–43 |year= 1998 |pmid= 9819420 |doi=
*cite journal | author=Yujiri T, Sather S, Fanger GR, Johnson GL |title=Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption. |journal=Science |volume=282 |issue= 5395 |pages= 1911–4 |year= 1998 |pmid= 9836645 |doi=
*cite journal | author=Baud V, Liu ZG, Bennett B, "et al." |title=Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. |journal=Genes Dev. |volume=13 |issue= 10 |pages= 1297–308 |year= 1999 |pmid= 10346818 |doi=
*cite journal | author=Kopp E, Medzhitov R, Carothers J, "et al." |title=ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. |journal=Genes Dev. |volume=13 |issue= 16 |pages= 2059–71 |year= 1999 |pmid= 10465784 |doi=
*cite journal | author=Ito M, Yoshioka K, Akechi M, "et al." |title=JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway. |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7539–48 |year= 1999 |pmid= 10523642 |doi=
*cite journal | author=Minamino T, Yujiri T, Papst PJ, "et al." |title=MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 26 |pages= 15127–32 |year= 2000 |pmid= 10611349 |doi=

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