MED1

MED1

Mediator complex subunit 1, also known as MED1, is a human gene.cite web | title = Entrez Gene: PPARBP PPAR binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5469| accessdate = ]

PBB_Summary
section_title =
summary_text = The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize.cite web | title = Entrez Gene: PPARBP PPAR binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5469| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lee JW, Choi HS, Gyuris J, "et al." |title=Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. |journal=Mol. Endocrinol. |volume=9 |issue= 2 |pages= 243–54 |year= 1995 |pmid= 7776974 |doi=
*cite journal | author=Fondell JD, Ge H, Roeder RG |title=Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 16 |pages= 8329–33 |year= 1996 |pmid= 8710870 |doi=
*cite journal | author=Zhu Y, Qi C, Jain S, "et al." |title=Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. |journal=J. Biol. Chem. |volume=272 |issue= 41 |pages= 25500–6 |year= 1997 |pmid= 9325263 |doi=
*cite journal | author=Drané P, Barel M, Balbo M, Frade R |title=Identification of RB18A, a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53. |journal=Oncogene |volume=15 |issue= 25 |pages= 3013–24 |year= 1998 |pmid= 9444950 |doi= 10.1038/sj.onc.1201492
*cite journal | author=Yuan CX, Ito M, Fondell JD, "et al." |title=The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 7939–44 |year= 1998 |pmid= 9653119 |doi=
*cite journal | author=Ryu S, Zhou S, Ladurner AG, Tjian R |title=The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. |journal=Nature |volume=397 |issue= 6718 |pages= 446–50 |year= 1999 |pmid= 9989412 |doi= 10.1038/17141
*cite journal | author=Gu W, Malik S, Ito M, "et al." |title=A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. |journal=Mol. Cell |volume=3 |issue= 1 |pages= 97–108 |year= 1999 |pmid= 10024883 |doi=
*cite journal | author=Ito M, Yuan CX, Malik S, "et al." |title=Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. |journal=Mol. Cell |volume=3 |issue= 3 |pages= 361–70 |year= 1999 |pmid= 10198638 |doi=
*cite journal | author=Rachez C, Lemon BD, Suldan Z, "et al." |title=Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. |journal=Nature |volume=398 |issue= 6730 |pages= 824–8 |year= 1999 |pmid= 10235266 |doi= 10.1038/19783
*cite journal | author=Näär AM, Beaurang PA, Zhou S, "et al." |title=Composite co-activator ARC mediates chromatin-directed transcriptional activation. |journal=Nature |volume=398 |issue= 6730 |pages= 828–32 |year= 1999 |pmid= 10235267 |doi= 10.1038/19789
*cite journal | author=Atkins GB, Hu X, Guenther MG, "et al." |title=Coactivators for the orphan nuclear receptor RORalpha. |journal=Mol. Endocrinol. |volume=13 |issue= 9 |pages= 1550–7 |year= 1999 |pmid= 10478845 |doi=
*cite journal | author=Zhu Y, Qi C, Jain S, "et al." |title=Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 19 |pages= 10848–53 |year= 1999 |pmid= 10485914 |doi=
*cite journal | author=Rachez C, Gamble M, Chang CP, "et al." |title=The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes. |journal=Mol. Cell. Biol. |volume=20 |issue= 8 |pages= 2718–26 |year= 2000 |pmid= 10733574 |doi=
*cite journal | author=Frade R, Balbo M, Barel M |title=RB18A, whose gene is localized on chromosome 17q12-q21.1, regulates in vivo p53 transactivating activity. |journal=Cancer Res. |volume=60 |issue= 23 |pages= 6585–9 |year= 2001 |pmid= 11118038 |doi=
*cite journal | author=Zilliacus J, Holter E, Wakui H, "et al." |title=Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140. |journal=Mol. Endocrinol. |volume=15 |issue= 4 |pages= 501–11 |year= 2001 |pmid= 11266503 |doi=
*cite journal | author=Crawford SE, Qi C, Misra P, "et al." |title=Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3585–92 |year= 2002 |pmid= 11724781 |doi= 10.1074/jbc.M107995200
*cite journal | author=Frade R, Balbo M, Barel M |title=RB18A regulates p53-dependent apoptosis. |journal=Oncogene |volume=21 |issue= 6 |pages= 861–6 |year= 2002 |pmid= 11840331 |doi= 10.1038/sj.onc.1205177
*cite journal | author=Kang YK, Guermah M, Yuan CX, Roeder RG |title=The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 5 |pages= 2642–7 |year= 2002 |pmid= 11867769 |doi= 10.1073/pnas.261715899
*cite journal | author=Misra P, Qi C, Yu S, "et al." |title=Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 20011–9 |year= 2002 |pmid= 11912212 |doi= 10.1074/jbc.M201739200
*cite journal | author=Ge K, Guermah M, Yuan CX, "et al." |title=Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. |journal=Nature |volume=417 |issue= 6888 |pages= 563–7 |year= 2002 |pmid= 12037571 |doi= 10.1038/417563a

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