MBD4

Methyl-CpG binding domain protein 4, also known as MBD4, is a human gene.cite web | title = Entrez Gene: MBD4 methyl-CpG binding domain protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8930| accessdate = ]

PBB_Summary
section_title =
summary_text = DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene.cite web | title = Entrez Gene: MBD4 methyl-CpG binding domain protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8930| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Boland CR, Thibodeau SN, Hamilton SR, "et al." |title=A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. |journal=Cancer Res. |volume=58 |issue= 22 |pages= 5248–57 |year= 1998 |pmid= 9823339 |doi=
*cite journal | author=Hendrich B, Bird A |title=Identification and characterization of a family of mammalian methyl-CpG binding proteins. |journal=Mol. Cell. Biol. |volume=18 |issue= 11 |pages= 6538–47 |year= 1998 |pmid= 9774669 |doi=
*cite journal | author=Bellacosa A, Cicchillitti L, Schepis F, "et al." |title=MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 7 |pages= 3969–74 |year= 1999 |pmid= 10097147 |doi=
*cite journal | author=Hendrich B, Abbott C, McQueen H, "et al." |title=Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes. |journal=Mamm. Genome |volume=10 |issue= 9 |pages= 906–12 |year= 1999 |pmid= 10441743 |doi=
*cite journal | author=Hendrich B, Hardeland U, Ng HH, "et al." |title=The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites. |journal=Nature |volume=401 |issue= 6750 |pages= 301–4 |year= 1999 |pmid= 10499592 |doi= 10.1038/45843
*cite journal | author=Riccio A, Aaltonen LA, Godwin AK, "et al." |title=The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability. |journal=Nat. Genet. |volume=23 |issue= 3 |pages= 266–8 |year= 1999 |pmid= 10545939 |doi= 10.1038/15443
*cite journal | author=Petronzelli F, Riccio A, Markham GD, "et al." |title=Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase. |journal=J. Biol. Chem. |volume=275 |issue= 42 |pages= 32422–9 |year= 2000 |pmid= 10930409 |doi= 10.1074/jbc.M004535200
*cite journal | author=Petronzelli F, Riccio A, Markham GD, "et al." |title=Investigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): fundamental role of the catalytic domain. |journal=J. Cell. Physiol. |volume=185 |issue= 3 |pages= 473–80 |year= 2000 |pmid= 11056019 |doi= 10.1002/1097-4652(200012)185:3<473::AID-JCP19>3.0.CO;2-# |doilabel=10.1002/1097-4652(200012)185:3473::AID-JCP193.0.CO;2-#
*cite journal | author=Schlegel J, Güneysu S, Mennel HD |title=Expression of the genes of methyl-binding domain proteins in human gliomas. |journal=Oncol. Rep. |volume=9 |issue= 2 |pages= 393–5 |year= 2002 |pmid= 11836615 |doi=
*cite journal | author=Jost JP, Thiry S, Siegmann M |title=Estradiol receptor potentiates, in vitro, the activity of 5-methylcytosine DNA glycosylase. |journal=FEBS Lett. |volume=527 |issue= 1-3 |pages= 63–6 |year= 2002 |pmid= 12220634 |doi=
*cite journal | author=Yamada T, Koyama T, Ohwada S, "et al." |title=Frameshift mutations in the MBD4/MED1 gene in primary gastric cancer with high-frequency microsatellite instability. |journal=Cancer Lett. |volume=181 |issue= 1 |pages= 115–20 |year= 2002 |pmid= 12430186 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Screaton RA, Kiessling S, Sansom OJ, "et al." |title=Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 9 |pages= 5211–6 |year= 2003 |pmid= 12702765 |doi= 10.1073/pnas.0431215100
*cite journal | author=Evertson S, Wallin A, Arbman G, "et al." |title=Microsatellite instability and MBD4 mutation in unselected colorectal cancer. |journal=Anticancer Res. |volume=23 |issue= 4 |pages= 3569–74 |year= 2003 |pmid= 12926109 |doi=
*cite journal | author=Lehner B, Semple JI, Brown SE, "et al." |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kondo E, Gu Z, Horii A, Fukushige S |title=The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16(INK4a) and hMLH1 genes. |journal=Mol. Cell. Biol. |volume=25 |issue= 11 |pages= 4388–96 |year= 2005 |pmid= 15899845 |doi= 10.1128/MCB.25.11.4388-4396.2005
*cite journal | author=Zhang X, Krutchinsky A, Fukuda A, "et al." |title=MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. |journal=Mol. Cell |volume=19 |issue= 1 |pages= 89–100 |year= 2005 |pmid= 15989967 |doi= 10.1016/j.molcel.2005.05.015
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

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