MBD3

Methyl-CpG binding domain protein 3, also known as MBD3, is a human gene.cite web | title = Entrez Gene: MBD3 methyl-CpG binding domain protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53615| accessdate = ]

PBB_Summary
section_title =
summary_text = DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex.cite web | title = Entrez Gene: MBD3 methyl-CpG binding domain protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53615| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Abbott WM, Mellor A, Edwards Y, Feizi T |title=Soluble bovine galactose-binding lectin. cDNA cloning reveals the complete amino acid sequence and an antigenic relationship with the major encephalitogenic domain of myelin basic protein. |journal=Biochem. J. |volume=259 |issue= 1 |pages= 283–90 |year= 1989 |pmid= 2470348 |doi=
*cite journal | author=Hendrich B, Bird A |title=Identification and characterization of a family of mammalian methyl-CpG binding proteins. |journal=Mol. Cell. Biol. |volume=18 |issue= 11 |pages= 6538–47 |year= 1998 |pmid= 9774669 |doi=
*cite journal | author=Zhang Y, LeRoy G, Seelig HP, "et al." |title=The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. |journal=Cell |volume=95 |issue= 2 |pages= 279–89 |year= 1998 |pmid= 9790534 |doi=
*cite journal | author=Tong JK, Hassig CA, Schnitzler GR, "et al." |title=Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. |journal=Nature |volume=395 |issue= 6705 |pages= 917–21 |year= 1998 |pmid= 9804427 |doi= 10.1038/27699
*cite journal | author=Hendrich B, Abbott C, McQueen H, "et al." |title=Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes. |journal=Mamm. Genome |volume=10 |issue= 9 |pages= 906–12 |year= 1999 |pmid= 10441743 |doi=
*cite journal | author=Zhang Y, Ng HH, Erdjument-Bromage H, "et al." |title=Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. |journal=Genes Dev. |volume=13 |issue= 15 |pages= 1924–35 |year= 1999 |pmid= 10444591 |doi=
*cite journal | author=Wade PA, Gegonne A, Jones PL, "et al." |title=Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. |journal=Nat. Genet. |volume=23 |issue= 1 |pages= 62–6 |year= 1999 |pmid= 10471500 |doi= 10.1038/12664
*cite journal | author=Tatematsu KI, Yamazaki T, Ishikawa F |title=MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase. |journal=Genes Cells |volume=5 |issue= 8 |pages= 677–88 |year= 2000 |pmid= 10947852 |doi=
*cite journal | author=Humphrey GW, Wang Y, Russanova VR, "et al." |title=Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6817–24 |year= 2001 |pmid= 11102443 |doi= 10.1074/jbc.M007372200
*cite journal | author=Shi Y, Downes M, Xie W, "et al." |title=Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. |journal=Genes Dev. |volume=15 |issue= 9 |pages= 1140–51 |year= 2001 |pmid= 11331609 |doi= 10.1101/gad.871201
*cite journal | author=Feng Q, Cao R, Xia L, "et al." |title=Identification and functional characterization of the p66/p68 components of the MeCP1 complex. |journal=Mol. Cell. Biol. |volume=22 |issue= 2 |pages= 536–46 |year= 2002 |pmid= 11756549 |doi=
*cite journal | author=Schlegel J, Güneysu S, Mennel HD |title=Expression of the genes of methyl-binding domain proteins in human gliomas. |journal=Oncol. Rep. |volume=9 |issue= 2 |pages= 393–5 |year= 2002 |pmid= 11836615 |doi=
*cite journal | author=Saito M, Ishikawa F |title=The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35434–9 |year= 2002 |pmid= 12124384 |doi= 10.1074/jbc.M203455200
*cite journal | author=Brackertz M, Boeke J, Zhang R, Renkawitz R |title=Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40958–66 |year= 2002 |pmid= 12183469 |doi= 10.1074/jbc.M207467200
*cite journal | author=Sakai H, Urano T, Ookata K, "et al." |title=MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase. |journal=J. Biol. Chem. |volume=277 |issue= 50 |pages= 48714–23 |year= 2003 |pmid= 12354758 |doi= 10.1074/jbc.M208461200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Fujita N, Jaye DL, Kajita M, "et al." |title=MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. |journal=Cell |volume=113 |issue= 2 |pages= 207–19 |year= 2003 |pmid= 12705869 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399
*cite journal | author=Fujita N, Jaye DL, Geigerman C, "et al." |title=MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. |journal=Cell |volume=119 |issue= 1 |pages= 75–86 |year= 2004 |pmid= 15454082 |doi= 10.1016/j.cell.2004.09.014

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