PDK2

Pyruvate dehydrogenase kinase, isozyme 2
PDB rendering based on 1jm6.
Available structures PDB 2BTZ, 2BU2, 2BU5, 2BU6, 2BU7, 2BU8
Identifiers
Symbols	PDK2;
External IDs	OMIM: 602525 MGI: 1343087 HomoloGene: 68265 GeneCards: PDK2 Gene
EC number	2.7.11.2
Gene Ontology Molecular function • two-component sensor activity • nucleotide binding • protein kinase activity • pyruvate dehydrogenase (acetyl-transferring) kinase activity • ATP binding • transferase activity Cellular component • nucleus • nucleolus • cytoplasm • mitochondrion • mitochondrial matrix Biological process • carbohydrate metabolic process • glucose metabolic process • pyruvate metabolic process • protein phosphorylation • regulation of acetyl-CoA biosynthetic process from pyruvate • peptidyl-histidine phosphorylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5164	18604
Ensembl	ENSG00000005882	ENSMUSG00000038967
UniProt	Q15119	Q8VC63
RefSeq (mRNA)	NM_001199898.1	NM_133667.2
RefSeq (protein)	NP_001186827.1	NP_598428.2
Location (UCSC)	Chr 17: 48.17 – 48.19 Mb	Chr 11: 94.89 – 94.9 Mb
PubMed search	[1]	[2]

Pyruvate dehydrogenase kinase isoform 2 (PDK2) also known as [pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial is an enzyme that in humans is encoded by the PDK2 gene.^[1][2] PDK2 is an isozyme of pyruvate dehydrogenase kinase.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^[3]

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Citric_acid_cycle edit

References

1. ^ Gudi R, Bowker-Kinley MM, Kedishvili NY, Zhao Y, Popov KM (Jan 1996). "Diversity of the pyruvate dehydrogenase kinase gene family in humans". J Biol Chem 270 (48): 28989–94. doi:10.1074/jbc.270.48.28989. PMID 7499431. 
2. ^ "Entrez Gene: PDK2 pyruvate dehydrogenase kinase, isozyme 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5164. 
3. ^ The interactive pathway map can be edited at WikiPathways: "TCACycle_WP78". http://www.wikipathways.org/index.php/Pathway:WP78. 

Further reading

• Sugden MC, Holness MJ (2003). "Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs.". Am. J. Physiol. Endocrinol. Metab. 284 (5): E855–62. doi:10.1152/ajpendo.00526.2002. PMID 12676647. 
• Kobayashi T, Cohen P (1999). "Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.". Biochem. J. 339 ( Pt 2) (2): 319–28. doi:10.1042/0264-6021:3390319. PMC 1220160. PMID 10191262. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220160. 
• Gold MR, Scheid MP, Santos L, et al. (1999). "The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase". J. Immunol. 163 (4): 1894–905. PMID 10438924. 
• Baker JC, Yan X, Peng T, et al. (2000). "Marked differences between two isoforms of human pyruvate dehydrogenase kinase". J. Biol. Chem. 275 (21): 15773–81. doi:10.1074/jbc.M909488199. PMID 10748134. 
• Steussy CN, Popov KM, Bowker-Kinley MM, et al. (2001). "Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinase". J. Biol. Chem. 276 (40): 37443–50. doi:10.1074/jbc.M104285200. PMC 2147663. PMID 11483605. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2147663. 
• Kolobova E, Tuganova A, Boulatnikov I, Popov KM (2001). "Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites". Biochem. J. 358 (Pt 1): 69–77. doi:10.1042/0264-6021:3580069. PMC 1222033. PMID 11485553. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222033. 
• Korotchkina LG, Patel MS (2001). "Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase". J. Biol. Chem. 276 (40): 37223–9. doi:10.1074/jbc.M103069200. PMID 11486000. 
• Peters SJ, Harris RA, Wu P, et al. (2002). "Human skeletal muscle PDH kinase activity and isoform expression during a 3-day high-fat/low-carbohydrate diet". Am. J. Physiol. Endocrinol. Metab. 281 (6): E1151–8. PMID 11701428. 
• Tuganova A, Boulatnikov I, Popov KM (2002). "Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex". Biochem. J. 366 (Pt 1): 129–36. doi:10.1042/BJ20020301. PMC 1222743. PMID 11978179. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222743. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Boulatnikov I, Popov KM (2003). "Formation of functional heterodimers by isozymes 1 and 2 of pyruvate dehydrogenase kinase". Biochim. Biophys. Acta 1645 (2): 183–92. doi:10.1016/S1570-9639(02)00542-3. PMID 12573248. 
• Hiromasa Y, Roche TE (2003). "Facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase". J. Biol. Chem. 278 (36): 33681–93. doi:10.1074/jbc.M212733200. PMID 12816949. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Watt MJ, Heigenhauser GJ, LeBlanc PJ, et al. (2005). "Rapid upregulation of pyruvate dehydrogenase kinase activity in human skeletal muscle during prolonged exercise". J. Appl. Physiol. 97 (4): 1261–7. doi:10.1152/japplphysiol.00132.2004. PMID 15169745. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Bao H, Kasten SA, Yan X, Roche TE (2004). "Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP". Biochemistry 43 (42): 13432–41. doi:10.1021/bi049488x. PMID 15491150. 
• Bao H, Kasten SA, Yan X, et al. (2004). "Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP". Biochemistry 43 (42): 13442–51. doi:10.1021/bi0494875. PMID 15491151. 
• Abbot EL, McCormack JG, Reynet C, et al. (2005). "Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells". FEBS J. 272 (12): 3004–14. doi:10.1111/j.1742-4658.2005.04713.x. PMID 15955060.