SGK

Serum/glucocorticoid regulated kinase, also known as SGK, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a serine/threonine protein kinase that is highly similar to the rat serum-and glucocorticoid-induced protein kinase (SGK). This gene was identified in a screen of hepatocellular genes regulated in response to cellular hydration or swelling. Cellular hydration is a catabolic signal, stimulating glycogenolysis and proteolysis, and inhibiting protein and glycogen synthesis. This kinase has been shown to be important in activating certain potassium, sodium, and chloride channels. Expression of this gene in hepatocytes is stimulated by transforming growth factor-beta (TGF-beta) which participates in the pathophysiology of diabetic complications. Since both TGF-beta expression and SGK expression are elevated in diabetic nephropathy, this suggests an involvement of SGK in the development of this condition. [cite web | title = Entrez Gene: SGK serum/glucocorticoid regulated kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6446| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lang F, Cohen P |title=Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms. |journal=Sci. STKE |volume=2001 |issue= 108 |pages= RE17 |year= 2002 |pmid= 11707620 |doi= 10.1126/stke.2001.108.re17
*cite journal | author=Waldegger S, Barth P, Raber G, Lang F |title=Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 9 |pages= 4440–5 |year= 1997 |pmid= 9114008 |doi=
*cite journal | author=Waldegger S, Erdel M, Nagl UO, "et al." |title=Genomic organization and chromosomal localization of the human SGK protein kinase gene. |journal=Genomics |volume=51 |issue= 2 |pages= 299–302 |year= 1998 |pmid= 9722955 |doi= 10.1006/geno.1998.5258
*cite journal | author=Kobayashi T, Cohen P |title=Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. |journal=Biochem. J. |volume=339 ( Pt 2) |issue= |pages= 319–28 |year= 1999 |pmid= 10191262 |doi=
*cite journal | author=Park J, Leong ML, Buse P, "et al." |title=Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. |journal=EMBO J. |volume=18 |issue= 11 |pages= 3024–33 |year= 1999 |pmid= 10357815 |doi= 10.1093/emboj/18.11.3024
*cite journal | author=Kobayashi T, Deak M, Morrice N, Cohen P |title=Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. |journal=Biochem. J. |volume=344 Pt 1 |issue= |pages= 189–97 |year= 2000 |pmid= 10548550 |doi=
*cite journal | author=Guan KL, Figueroa C, Brtva TR, "et al." |title=Negative regulation of the serine/threonine kinase B-Raf by Akt. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27354–9 |year= 2000 |pmid= 10869359 |doi= 10.1074/jbc.M004371200
*cite journal | author=Lang F, Klingel K, Wagner CA, "et al." |title=Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 14 |pages= 8157–62 |year= 2000 |pmid= 10884438 |doi=
*cite journal | author=Brunet A, Park J, Tran H, "et al." |title=Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). |journal=Mol. Cell. Biol. |volume=21 |issue= 3 |pages= 952–65 |year= 2001 |pmid= 11154281 |doi= 10.1128/MCB.21.3.952-965.2001
*cite journal | author=Hayashi M, Tapping RI, Chao TH, "et al." |title=BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase. |journal=J. Biol. Chem. |volume=276 |issue= 12 |pages= 8631–4 |year= 2001 |pmid= 11254654 |doi= 10.1074/jbc.C000838200
*cite journal | author=Zhang BH, Tang ED, Zhu T, "et al." |title=Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf. |journal=J. Biol. Chem. |volume=276 |issue= 34 |pages= 31620–6 |year= 2001 |pmid= 11410590 |doi= 10.1074/jbc.M102808200
*cite journal | author=Snyder PM, Olson DR, Thomas BC |title=Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 5–8 |year= 2002 |pmid= 11696533 |doi= 10.1074/jbc.C100623200
*cite journal | author=Debonneville C, Flores SY, Kamynina E, "et al." |title=Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression. |journal=EMBO J. |volume=20 |issue= 24 |pages= 7052–9 |year= 2002 |pmid= 11742982 |doi= 10.1093/emboj/20.24.7052
*cite journal | author=Yun CC, Chen Y, Lang F |title=Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 7676–83 |year= 2002 |pmid= 11751930 |doi= 10.1074/jbc.M107768200
*cite journal | author=Lizcano JM, Deak M, Morrice N, "et al." |title=Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27839–49 |year= 2002 |pmid= 12023960 |doi= 10.1074/jbc.M202042200
*cite journal | author=Waerntges S, Klingel K, Weigert C, "et al." |title=Excessive transcription of the human serum and glucocorticoid dependent kinase hSGK1 in lung fibrosis. |journal=Cell. Physiol. Biochem. |volume=12 |issue= 2-3 |pages= 135–42 |year= 2003 |pmid= 12077559 |doi=
*cite journal | author=Busjahn A, Aydin A, Uhlmann R, "et al." |title=Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure. |journal=Hypertension |volume=40 |issue= 3 |pages= 256–60 |year= 2002 |pmid= 12215463 |doi=
*cite journal | author=Brickley DR, Mikosz CA, Hagan CR, Conzen SD |title=Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1). |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 43064–70 |year= 2003 |pmid= 12218062 |doi= 10.1074/jbc.M207604200
*cite journal | author=Itani OA, Liu KZ, Cornish KL, "et al." |title=Glucocorticoids stimulate human sgk1 gene expression by activation of a GRE in its 5'-flanking region. |journal=Am. J. Physiol. Endocrinol. Metab. |volume=283 |issue= 5 |pages= E971–9 |year= 2002 |pmid= 12376324 |doi= 10.1152/ajpendo.00021.2002

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