MAPK3

Main article: Extracellular signal-regulated kinases

Mitogen-activated protein kinase 3
Identifiers
Symbols	MAPK3; ERK1; HS44KDAP; HUMKER1A; MGC20180; P44ERK1; P44MAPK; PRKM3
External IDs	OMIM: 601795 MGI: 1346859 HomoloGene: 55682 GeneCards: MAPK3 Gene
EC number	2.7.11.24
Gene Ontology Molecular function • nucleotide binding • phosphotyrosine binding • protein serine/threonine kinase activity • MAP kinase activity • MAP kinase activity • protein binding • ATP binding • kinase activity • kinase activity • phosphatase binding Cellular component • nucleus • nucleoplasm • nucleoplasm • cytoplasm • cytosol • cytosol Biological process • MAPKKK cascade • MAPKKK cascade • activation of MAPKK activity • activation of MAPK activity • toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • transcription from RNA polymerase I promoter • transcription initiation from RNA polymerase I promoter • protein phosphorylation • response to DNA damage stimulus • cell cycle • epidermal growth factor receptor signaling pathway • small GTPase mediated signal transduction • Ras protein signal transduction • axon guidance • blood coagulation • Toll signaling pathway • insulin receptor signaling pathway • organ morphogenesis • phosphorylation • sensory perception of pain • platelet activation • lipopolysaccharide-mediated signaling pathway • response to lipopolysaccharide • positive regulation of histone phosphorylation • toll-like receptor 1 signaling pathway • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • positive regulation of histone acetylation • response to exogenous dsRNA • interspecies interaction between organisms • innate immune response • positive regulation of transcription from RNA polymerase II promoter • nerve growth factor receptor signaling pathway • regulation of sequence-specific DNA binding transcription factor activity • cartilage development • stress-activated MAPK cascade • interleukin-1-mediated signaling pathway • cellular response to mechanical stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5595	26417
Ensembl	ENSG00000102882	ENSMUSG00000063065
UniProt	P27361	Q63844
RefSeq (mRNA)	NM_001040056.1	NM_011952.2
RefSeq (protein)	NP_001035145.1	NP_036082.1
Location (UCSC)	Chr 16: 30.13 – 30.13 Mb	Chr 7: 133.9 – 133.91 Mb
PubMed search	[1]	[2]

Mitogen-activated protein kinase 3 is an enzyme that in humans is encoded by the MAPK3 gene.^[1]

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.^[2]

Interactions

MAPK3 has been shown to interact with PTPN7,^[3][4][5] SPIB,^[6] GTF2I,^[7] DUSP3,^[8] HDAC4,^[9] RPS6KA2,^[10][11] MAP2K1,^{[12][13][14][15][16]} DUSP6^[17] and MAP2K2.^[12][13][16]

References

1. ^ Garcia F, Zalba G, Paez G, Encio I, de Miguel C (Apr 1999). "Molecular cloning and characterization of the human p44 mitogen-activated protein kinase gene". Genomics 50 (1): 69–78. doi:10.1006/geno.1998.5315. PMID 9628824. 
2. ^ "Entrez Gene: MAPK3 mitogen-activated protein kinase 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5595. 
3. ^ Pettiford, S M; Herbst R (Feb. 2000). "The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP". Oncogene (ENGLAND) 19 (7): 858–69. doi:10.1038/sj.onc.1203408. ISSN 0950-9232. PMID 10702794. 
4. ^ Saxena, M; Williams S, Taskén K, Mustelin T (Sep. 1999). "Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase". Nat. Cell Biol. (ENGLAND) 1 (5): 305–11. doi:10.1038/13024. ISSN 1465-7392. PMID 10559944. 
5. ^ Saxena, M; Williams S, Brockdorff J, Gilman J, Mustelin T (Apr. 1999). "Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP)". J. Biol. Chem. (UNITED STATES) 274 (17): 11693–700. doi:10.1074/jbc.274.17.11693. ISSN 0021-9258. PMID 10206983. 
6. ^ Mao, C; Ray-Gallet D, Tavitian A, Moreau-Gachelin F (Feb. 1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors". Oncogene (ENGLAND) 12 (4): 863–73. ISSN 0950-9232. PMID 8632909. 
7. ^ Kim, D W; Cochran B H (Feb. 2000). "Extracellular signal-regulated kinase binds to TFII-I and regulates its activation of the c-fos promoter". Mol. Cell. Biol. (UNITED STATES) 20 (4): 1140–8. doi:10.1128/MCB.20.4.1140-1148.2000. ISSN 0270-7306. PMC 85232. PMID 10648599. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85232. 
8. ^ Todd, J L; Tanner K G, Denu J M (May. 1999). "Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway". J. Biol. Chem. (UNITED STATES) 274 (19): 13271–80. doi:10.1074/jbc.274.19.13271. ISSN 0021-9258. PMID 10224087. 
9. ^ Zhou, X; Richon V M, Wang A H, Yang X J, Rifkind R A, Marks P A (Dec. 2000). "Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (26): 14329–33. doi:10.1073/pnas.250494697. ISSN 0027-8424. PMC 18918. PMID 11114188. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=18918. 
10. ^ Roux, Philippe P; Richards Stephanie A, Blenis John (Jul. 2003). "Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity". Mol. Cell. Biol. (United States) 23 (14): 4796–804. doi:10.1128/MCB.23.14.4796-4804.2003. ISSN 0270-7306. PMC 162206. PMID 12832467. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=162206. 
11. ^ Zhao, Y; Bjorbaek C, Moller D E (Nov. 1996). "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases". J. Biol. Chem. (UNITED STATES) 271 (47): 29773–9. doi:10.1074/jbc.271.47.29773. ISSN 0021-9258. PMID 8939914. 
12. ^ ^{a b} Marti, A; Luo Z, Cunningham C, Ohta Y, Hartwig J, Stossel T P, Kyriakis J M, Avruch J (Jan. 1997). "Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells". J. Biol. Chem. (UNITED STATES) 272 (5): 2620–8. doi:10.1074/jbc.272.5.2620. ISSN 0021-9258. PMID 9006895. 
13. ^ ^{a b} Butch, E R; Guan K L (Feb. 1996). "Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2". J. Biol. Chem. (UNITED STATES) 271 (8): 4230–5. doi:10.1074/jbc.271.8.4230. ISSN 0021-9258. PMID 8626767. 
14. ^ Schaeffer, H J; Catling A D, Eblen S T, Collier L S, Krauss A, Weber M J (Sep. 1998). "MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade". Science (UNITED STATES) 281 (5383): 1668–71. doi:10.1126/science.281.5383.1668. ISSN 0036-8075. PMID 9733512. 
15. ^ Yung, Y; Yao Z, Hanoch T, Seger R (May. 2000). "ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK". J. Biol. Chem. (UNITED STATES) 275 (21): 15799–808. doi:10.1074/jbc.M910060199. ISSN 0021-9258. PMID 10748187. 
16. ^ ^{a b} Zheng, C F; Guan K L (Nov. 1993). "Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases". J. Biol. Chem. (UNITED STATES) 268 (32): 23933–9. ISSN 0021-9258. PMID 8226933. 
17. ^ Muda, M; Theodosiou A, Gillieron C, Smith A, Chabert C, Camps M, Boschert U, Rodrigues N, Davies K, Ashworth A, Arkinstall S (Apr. 1998). "The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding and enzymatic specificity". J. Biol. Chem. (UNITED STATES) 273 (15): 9323–9. doi:10.1074/jbc.273.15.9323. ISSN 0021-9258. PMID 9535927. 

External Links

• MAP Kinase Resource .

Further reading

• Peruzzi F, Gordon J, Darbinian N, Amini S (2003). "Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway.". J. Neurovirol. 8 Suppl 2 (2): 91–6. doi:10.1080/13550280290167885. PMID 12491158. 
• Meloche S, Pouysségur J (2007). "The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition". Oncogene 26 (22): 3227–39. doi:10.1038/sj.onc.1210414. PMID 17496918. 
• Ruscica M, Dozio E, Motta M, Magni P (2007). Modulatory Actions of Neuropeptide Y on Prostate Cancer Growth: Role of MAP Kinase/ERK 1/2 Activatio. "Modulatory actions of neuropeptide Y on prostate cancer growth: role of MAP kinase/ERK 1/2 activation". Adv. Exp. Med. Biol.. Advances In Experimental Medicine And Biology 604: 96–100. doi:10.1007/978-0-387-69116-9_7. ISBN 978-0-387-69114-5. PMID 17695723.